{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T13:17:07Z","timestamp":1772371027656,"version":"3.50.1"},"reference-count":0,"publisher":"Canadian Urological Association Journal","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CUAJ"],"abstract":"<jats:p>Introduction: Patients with a history of bladder pain syndrome\/interstitial cystitis (BPS\/IC) and who responded poorly or unsatisfactorily with previous treatment were compared taking intravesical hyaluronic acid (HA) or hyaluronic acid-chondroitin sulphate (HA-CS).Methods: Patients were treated with intravesical instillation with 50 mL sterile sodium hyalurinic acid (Hyacyst, Syner-Med, Surrey, UK) (n = 32) and sodium hyaluronate 1.6% sodium chondroitin sulphate 2% (Ialuril, Aspire Pharma, UK) (n = 33). Intravesical instillations were performed weekly in first month, every 15 days in the second month and monthly in third and fourth months, for a total of 8 doses. Patients were evaluated using a visual analog pain scale (VAS), interstitial cystitis symptom index (ICSI), interstitial cystitis problem index (ICPI), voiding diary for frequency\/nocturia, cystometric bladder capacity and voided volume at the beginning and at 6 months. All patients had a potassium sensitivity test (PST) initially. Wilcoxon and Mann-Whitney U tests were used for statistical analysis.Results: In total, 53 patients met the study criteria. There were 30 patients in the HA-CS group (mean age: 48.47) and 23 patients in the HA group (mean age: 49.61) (p &gt; 0.05). The initial PST was positive in 71.7% patients (38\/53) overall with no difference between groups (p &gt; 0.05). Responses for VAS, ICCS, ICPS, 24-hour frequency\/nocturia statistically improved in both groups at 6 months. There was no significant difference in symptomatic improvement (p &gt; 0.05). Eight patients had mild adverse events.Conclusion: HA and HA\/CS instillation can be effective in BPS\/IC patients who do not respond to conservative treatment. An important limitation of our study is that the HA dosage of the 2 treatment arms were different. It would be more appropriate with same HA dosage in both groups; however, there was no commercially available glycosaminoglycan (GAG) substance with same HA dosage for single and combination therapy. Large, long-term randomized studies are required to determine if there is a difference between these treatments.<\/jats:p>","DOI":"10.5489\/cuaj.2036","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T18:09:31Z","timestamp":1410286171000},"page":"610","source":"Crossref","is-referenced-by-count":23,"title":["Clinical comparision of intravesical hyaluronic acid and hyaluronic acid-chondroitin sulphate therapy for patients with bladder pain syndrome\/interstitital cystitis"],"prefix":"10.5489","volume":"8","author":[{"given":"\u00d6mer","family":"G\u00fclp\u0131nar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayta\u00e7","family":"Kay\u0131\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evren","family":"S\u00fcer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet \u0130lker","family":"G\u00f6k\u00e7e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adil G\u00fc\u00e7al","family":"G\u00fc\u00e7l\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihat","family":"Ar\u0131kan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3456","published-online":{"date-parts":[[2014,9,9]]},"container-title":["Canadian Urological Association Journal"],"original-title":[],"link":[{"URL":"http:\/\/cuaj.ca\/index.php\/journal\/article\/viewFile\/2036\/1843","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/cuaj.ca\/index.php\/journal\/article\/viewFile\/2036\/1843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T16:17:44Z","timestamp":1476202664000},"score":1,"resource":{"primary":{"URL":"http:\/\/cuaj.ca\/index.php\/journal\/article\/view\/2036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,9]]},"references-count":0,"journal-issue":{"issue":"9-10","published-online":{"date-parts":[[2014,9,9]]}},"URL":"https:\/\/doi.org\/10.5489\/cuaj.2036","relation":{},"ISSN":["1920-1214"],"issn-type":[{"value":"1920-1214","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,9]]}}}