{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:47:04Z","timestamp":1762980424696},"reference-count":0,"publisher":"Canadian Urological Association Journal","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CUAJ"],"abstract":"<jats:p>Introduction: We sought to assess the long-term results of conservative\u00a0treatment for upper urinary tract carcinoma (UUTC) with regard\u00a0to tumour recurrence and preservation of renal unit.Methods: From October 1987 to January 2014, 65 patients (median\u00a0age 68 years) were diagnosed with UUTC and underwent endoscopic\u00a0and open surgical techniques. Thirteen patients had bilateral\u00a0disease and one had a single kidney. The primary approach was\u00a0endoscopic in 37 reno-ureteral units (20 percutaneous resections,\u00a017 ureteroscopies ). Open surgery was performed in 19 cases. A\u00a0total of 20 patients received mitomycin C.Results: Superficial stage pTa or T1 was noted in 37 patients, infiltrating\u00a0stage pT2 and pT3 in seven and inverted papilloma in one.\u00a0The stage of the tumour was impossible to classify in 20. With\u00a0a median followup of 75.12 months (interquartile range [IQR]\u00a0144.71\u201317.41), the kidney preservation, recurrence, specific survival,\u00a0and global survival rates were 78.5% (51\/65), 40.0% (26\/65),\u00a092.3% (60\/65), and 69.2% (45\/65), respectively. From the patients\u00a0who had recurrence, 15 were salvaged with radical nephroureterectomy\u00a0(RNU). The bladder tumour recurrence rate after the surgery\u00a0was 30.76% (20\/65). At the end of the followup, five patients had\u00a0died of UUTC progression and 16 from other causes. Postoperative\u00a0complications included one case of fistula, one case of stricture,\u00a0and one case of nephrectomy due to bleeding.Conclusions: In selected cases, conservative management is a safe\u00a0and feasible alternative to RNU, with the advantage of renal unit\u00a0preservation.<\/jats:p>","DOI":"10.5489\/cuaj.4173","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T19:57:17Z","timestamp":1499803037000},"page":"E291-6","source":"Crossref","is-referenced-by-count":3,"title":["Conservative treatment of upper urinary tract carcinoma: Long-term results"],"prefix":"10.5489","volume":"11","author":[{"given":"Andrea","family":"Orosa Andrada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e9s","family":"Laso Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Arias F\u00fanez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Donis Canet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Duque Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"G\u00f3mez Dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Burgos Revilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3456","published-online":{"date-parts":[[2017,7,11]]},"container-title":["Canadian Urological Association Journal"],"original-title":[],"link":[{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/download\/4173\/3209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/download\/4173\/3209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T10:24:59Z","timestamp":1563013499000},"score":1,"resource":{"primary":{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/view\/4173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,11]]},"references-count":0,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,7,11]]}},"URL":"https:\/\/doi.org\/10.5489\/cuaj.4173","relation":{},"ISSN":["1920-1214","1911-6470"],"issn-type":[{"value":"1920-1214","type":"electronic"},{"value":"1911-6470","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7,11]]}}}