{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T13:33:49Z","timestamp":1747229629734,"version":"3.40.5"},"reference-count":0,"publisher":"Canadian Urological Association Journal","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CUAJ"],"abstract":"<jats:p>Introduction: The goal of medical therapy for infertile men with testosterone deficiency (TD) is to improve intratesticular testosterone (ITT). There is a gap in knowledge to identify those who will respond with semen parameter(s) improvement. We hypothesized that serum 17-hydroxyprogesterone (17-OHP) \u2014 a marker of ITT \u2014 can be used to predict improvement of semen parameter(s).\r\nMethods: Between July 2018 and January 2020, we conducted a prospective study of 31 men with primary infertility, TD, and secondary hypogonadism receiving clomiphene citrate (CC) and\/or human chorionic gonadotropin (hCG) for three months. We assessed baseline and followup hormones, including testosterone, 17-OHP, semen parameter(s), and demographics. Semen quality upgrading was based on assisted reproduction eligibility: in-vitro fertilization (&lt;5 million), intrauterine insemination (IUI) (5\u20139 million), and natural pregnancy (&gt;9 million). Variables were compared using the Mann-Whitney U or Wilcoxon rank test.\r\nResults: Twenty-one men received CC and 10 received CC\/hCG. Median followup was 3.7 (3.3\u20135.1) months. Sixteen men upgraded semen quality. Six of 10 men with baseline total motile sperm count (TMSC) of 0 had motile sperm after treatment, and 11\/20 men with TMSC&lt;5 upgraded semen quality into TMSC&gt;5 range. Low 17-OHP was the only factor that predicted semen quality upgrading. Men with 17-OHP \u226455 ng\/dL upgraded semen quality and improved hormones, whereas men with 17-OHP &gt;55 ng\/dL did not upgrade semen quality.\r\nConclusions: Medical therapy for infertile men with TD resulted in the improvement of sperm concentration, TMSC, testosterone, and 17-OHP. Semen quality upgrading appears to be more significant in patients with low 17-OHP, suggesting that ITT can be used as a biomarker to predict semen parameter(s) improvement.<\/jats:p>","DOI":"10.5489\/cuaj.6846","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T10:45:03Z","timestamp":1608115503000},"source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of a serum 17-hydroxyprogesterone as predictor of semen parameter(s) improvement in men undergoing medical treatment for infertility"],"prefix":"10.5489","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7410-7025","authenticated-orcid":false,"given":"Thiago Fernandes Negris","family":"Lima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-6366","authenticated-orcid":false,"given":"Evgeniya","family":"Rakitina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9700-0805","authenticated-orcid":false,"given":"Ruben","family":"Blachman-Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1387-7904","authenticated-orcid":false,"given":"Ranjith","family":"Ramasamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3456","published-online":{"date-parts":[[2020,12,15]]},"container-title":["Canadian Urological Association Journal"],"original-title":[],"link":[{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/download\/6846\/4723","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/download\/6846\/4723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T10:45:04Z","timestamp":1608115504000},"score":1,"resource":{"primary":{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/view\/6846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,15]]},"references-count":0,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,12,15]]}},"URL":"https:\/\/doi.org\/10.5489\/cuaj.6846","relation":{},"ISSN":["1920-1214","1911-6470"],"issn-type":[{"type":"electronic","value":"1920-1214"},{"type":"print","value":"1911-6470"}],"subject":[],"published":{"date-parts":[[2020,12,15]]}}}