{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:18:31Z","timestamp":1783012711178,"version":"3.54.6"},"reference-count":0,"publisher":"Canadian Urological Association Journal","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CUAJ"],"abstract":"<jats:p>Introduction: We aimed to determine whether anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid (18F-fluciclovine) positron emission tomography\/computed tomography (PET\/CT) can accurately detect residual non-seminomatous germ cell tumor (NSGCT) prior to retroperitoneal lymph node dissection (RPLND). There is no reliable way to differentiate between fibrosis\/necrosis, teratoma, and viable germ cell tumor in patients receiving post-chemotherapy RPLND. Functional imaging, including 18F-fludeoxyglucose (18F-FDG) PET\/CT, has been disappointing. Due to the need for better imaging modalities, our prospective, pilot study aims to investigate the accuracy of 18F-fluciclovine PET\/CT in detecting residual tumor prior to RPLND.\nMethods: From March 2018 to May 2019, 10 eligible patients underwent preoperative 18F-fluciclovine PET\/CT prior to undergoing bilateral, full-template RPLND or excision of mass (for one re-do RPLND) in a prospective, phase 2 study. Correlation between 18F-fluciclovine PET\/CT and RPLND pathology were evaluated on a per-patient level.\nResults: A total of 10 patients (mean age 29\u00b17.6 years) underwent 18F-fluciclovine PET\/CT prior to surgery. Nine of 10 patients received chemotherapy prior to RPLND. Correlation between 18F-fluciclovine PET\/CT and RPLND pathology was seen in 3\/10 (30%) patients. Five of 10 patients (50%) with negative 18F-fluciclovine PET\/CT were found to have residual disease\/teratoma on RPLND. Compared to the reference standard of RPLND, 18F-fluciclovine PET\/CT demonstrated 29% sensitivity and 33% specificity. No patients experienced any adverse events due to 18F-fluciclovine PET\/CT.\nConclusions: Despite a different mechanism of action from 18F-FDG, 18F-fluciclovine has low sensitivity and specificity for residual teratoma in the retroperitoneum.<\/jats:p>","DOI":"10.5489\/cuaj.7317","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T10:15:07Z","timestamp":1637144107000},"source":"Crossref","is-referenced-by-count":2,"title":["Performance characteristics of 18F-fluciclovine positron emission tomography\/computed tomography prior to retroperitoneal lymph node dissection"],"prefix":"10.5489","volume":"16","author":[{"given":"Solomon L.","family":"Woldu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fady","family":"Baky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly","family":"Margulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rathan M.","family":"Subramaniam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Bagrodia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3456","published-online":{"date-parts":[[2021,6,11]]},"container-title":["Canadian Urological Association Journal"],"original-title":[],"link":[{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/download\/7317\/5141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/download\/7317\/5141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T10:15:11Z","timestamp":1637144111000},"score":1,"resource":{"primary":{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/view\/7317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,11]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,10,18]]}},"URL":"https:\/\/doi.org\/10.5489\/cuaj.7317","relation":{},"ISSN":["1920-1214","1911-6470"],"issn-type":[{"value":"1920-1214","type":"electronic"},{"value":"1911-6470","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,11]]}}}