{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:58:21Z","timestamp":1773154701852,"version":"3.50.1"},"reference-count":0,"publisher":"Canadian Urological Association Journal","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CUAJ"],"abstract":"<jats:p>Introduction: Our objective was to assess the effect of 18F-DCFPyL prostate-specific membrane antigen (PSMA) positron emission tomography (PET) on the management and outcomes of patients receiving salvage radiotherapy following biochemical failure (BF) post-radical prostatectomy (RP) using a matched cohort analysis.\nMethods: A PSMA-PET cohort of patients with BF post-RP was identified through a prospective registry. Patients from this registry were included if they did not have disease outside of the pelvis and underwent salvage radiotherapy to the prostate and\/or pelvis. Case-control matching was performed with a contemporary cohort of patients with BF post-RP without PSMA-PET information.\nResults: Forty-four patients were included in the PSMA-PET cohort and 80 were analyzed in the non-PSMA-PET cohort. The PSMA-PET cohort had a significantly higher pre-radiotherapy median prostate-specific antigen (PSA) of 0.48 ng\/mL compared to 0.20 ng\/mL in the non-PSMA-PET cohort (p&lt;0.001) but these levels were similar after matching. The PSMA-PET cohort had a higher proportion of patients receiving radiotherapy to pelvic lymph nodes (n=27 [61.4%] vs. n=16 [20.0%], p&lt;0.001). Median followup was 26 months (interquartile range 18.8\u201333) for both cohorts\u00ac. BF-free survival and event-free survival were not significantly different between the two cohorts for all (p=0.662 and &gt;0.99) and matched patients (p=0.808 and 0.808), respectively. Metastasis-free survival was significantly higher in the matched PSMA-PET cohort compared to the matched non-PSMA-PET cohort (p=0.046), although a higher proportion of patients in the non-PSMA-PET cohort underwent PSMA-PET restaging after BF (52 vs. 20%, p=0.08726).\nConclusions: Our study showed that patients undergoing PSMA-PET scans after BF post-RP had a higher likelihood of pelvic nodal treatment at the time of salvage RT. Despite higher PSA levels at salvage, we identified no recurrence or survival differences.<\/jats:p>","DOI":"10.5489\/cuaj.8165","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T09:10:20Z","timestamp":1685524220000},"source":"Crossref","is-referenced-by-count":1,"title":["18F-DCFPyL PSMA-PET affects management of salvage radiotherapy for post-prostatectomy patients with biochemical failure"],"prefix":"10.5489","volume":"17","author":[{"given":"Andrew J.","family":"Arifin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Gulstene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Warner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn S.","family":"Bauman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas C.","family":"Mendez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3456","published-online":{"date-parts":[[2023,5,30]]},"container-title":["Canadian Urological Association Journal"],"original-title":[],"link":[{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/download\/8165\/5699","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/download\/8165\/5699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T09:10:31Z","timestamp":1685524231000},"score":1,"resource":{"primary":{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/view\/8165"}},"subtitle":["A matched cohort study"],"short-title":[],"issued":{"date-parts":[[2023,5,30]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,5,30]]}},"URL":"https:\/\/doi.org\/10.5489\/cuaj.8165","relation":{},"ISSN":["1920-1214","1911-6470"],"issn-type":[{"value":"1920-1214","type":"electronic"},{"value":"1911-6470","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5,30]]}}}