{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T10:10:00Z","timestamp":1752401400917,"version":"3.41.2"},"reference-count":0,"publisher":"Canadian Urological Association Journal","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CUAJ"],"abstract":"<jats:p>Introduction: We aimed to assess the impact of age of the initial dextranomer\/hyaluronic acid (Dx\/HA) injection on the subsequent outcome, including the need for repeated injections.\nMethods: The charts of patients who underwent Dx\/HA injection from 2010-2020 were retrospectively reviewed. Two groups were created according to the number of Dx\/HA injections: single vs. repeated injections. Patients presented with antenatal hydronephrosis, neurogenic bladder and followup less than one year after the first injection were excluded. Repeated Dx\/HA injections were indicated in patients with documented vesicoureteric reflux (VUR) who experienced recurrent febrile urinary tract infection (FUTI) postoperatively.\nResults: A total of 172 patients with 189 renal units were included; 139 (73.5%) units underwent single injections, whereas 50 (26.5%) had repeated injections. Twenty-three (48.9%) patients with repeated injections were presented before the age of one year vs. 37 (29.6%) after the age of one year (p=0.02). Of the repeated group, 34 (68%) units received two injections, 14 (28%) were injected three times or more, and two (4%) had other treatment modalities. Forty-four percent of units requiring repeated injections had high-grade VUR (grades 4 and 5), compared to only 22.3% of units successfully treated with a single injection (p=0.003).\nConclusions: In our cohort, 26.5% of renal units underwent repeated Dx\/HA injections. Forty-four percent of units with repeated injections had grade 4-5 VUR. Patients with VUR presented with FUTI before the age of one year old were at higher risk of repeated injections than those who presented later.<\/jats:p>","DOI":"10.5489\/cuaj.9150","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:50:36Z","timestamp":1752141036000},"source":"Crossref","is-referenced-by-count":0,"title":["Dextranomer\/hyaluronic acid injections for patients with vesicoureteral reflux"],"prefix":"10.5489","volume":"19","author":[{"given":"Bryce","family":"Weber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Mandourah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Hodhod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadeel","family":"Eid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Fermin-Risso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutaz","family":"Farhad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarrah","family":"Aburezeq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Al-Soufiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"El-Gharbaway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3456","published-online":{"date-parts":[[2025,7,8]]},"container-title":["Canadian Urological Association Journal"],"original-title":[],"link":[{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/download\/9150\/6495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/download\/9150\/6496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T09:51:15Z","timestamp":1752400275000},"score":1,"resource":{"primary":{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/view\/9150"}},"subtitle":["Does the age at injection predict the outcome?"],"short-title":[],"issued":{"date-parts":[[2025,7,8]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,7,8]]}},"URL":"https:\/\/doi.org\/10.5489\/cuaj.9150","relation":{},"ISSN":["1920-1214","1911-6470"],"issn-type":[{"type":"electronic","value":"1920-1214"},{"type":"print","value":"1911-6470"}],"subject":[],"published":{"date-parts":[[2025,7,8]]}}}