{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:34:40Z","timestamp":1768318480934,"version":"3.49.0"},"reference-count":0,"publisher":"Canadian Urological Association Journal","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CUAJ"],"abstract":"<jats:p>Introduction: Low vitamin D is a possible risk factor among calcium oxalate (CaOx) stone formers, although its routine assessment and the role for supplementation remain controversial. This study aimed to examine the prevalence of low vitamin D in a large Canadian cohort and to assess the impact of replacement therapy on metabolic and radiographic outcomes.\nMethods: A retrospective review of patients with CaOx stones who underwent a full metabolic evaluation, including two 24-hour urine collections in a multidisciplinary metabolic stone clinic, was conducted to determine the prevalence of 25-hydroxy vitamin D (25-OH vitamin D) deficiency\/insufficiency. A subset of patients receiving vitamin D supplementation was assessed longitudinally for changes in metabolic parameters and stone growth and compared to a cohort with normal values.\nResults: Among 748 patients, 64% had low vitamin D levels at baseline. These patients were more likely to be younger (53 [42.5\uf02d61] years vs. 57 [44\uf02d67], p&lt;0.001), have a higher body mass index (BMI) (29.3 [25.7\u201333.3) kg\/m2 vs. 27.5 [24.3\u201331.9], p&lt;0.001), and to be male (53.6 vs 44.4%, p=0.019). Among 83 patients receiving vitamin D with a mean followup of 4.8 years, none became hypercalcemic. Serial imaging demonstrated 41% had an increase in stone burden over time, which was not significantly different from those not requiring supplementation.\nConclusions: Low vitamin D is very common among Canadian CaOx stone formers and should be a routine part of an in-depth metabolic workup. Vitamin D administration can be safely recommended to stone formers without risk of inducing stone progression.<\/jats:p>","DOI":"10.5489\/cuaj.9184","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:50:02Z","timestamp":1752141002000},"source":"Crossref","is-referenced-by-count":1,"title":["The prevalence of vitamin D deficiency and insufficiency in calcium oxalate stone formers in Ontario, Canada, and the impact of vitamin D supplementation"],"prefix":"10.5489","volume":"19","author":[{"given":"Mario","family":"Basulto-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoya","family":"Khandwala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Alotaibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solon","family":"Ierides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Bjazevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stan","family":"Van Uum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin K.","family":"Clemens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan","family":"Razvi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3456","published-online":{"date-parts":[[2025,7,8]]},"container-title":["Canadian Urological Association Journal"],"original-title":[],"link":[{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/download\/9184\/6489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/download\/9184\/6489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T09:50:39Z","timestamp":1752400239000},"score":1,"resource":{"primary":{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/view\/9184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,8]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,7,8]]}},"URL":"https:\/\/doi.org\/10.5489\/cuaj.9184","relation":{},"ISSN":["1920-1214","1911-6470"],"issn-type":[{"value":"1920-1214","type":"electronic"},{"value":"1911-6470","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7,8]]}}}