{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T20:20:04Z","timestamp":1784578804235,"version":"3.55.0"},"reference-count":0,"publisher":"Canadian Urological Association Journal","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CUAJ"],"abstract":"<jats:p>Introduction: Nerve-sparing during radical prostatectomy (RP) is associated with improved postoperative erectile function and urinary continence but may increase risk of positive surgical margins. This study sought to compare the long-term outcomes of patients treated with nerve-spare (NS) compared to wide resection (WR).\nMethods: A historical cohort of consecutive patients was reviewed. A standardized surgical approach of lobe-specific NS or WR was performed. The primary outcome was treatment failure, defined as prostate-specific antigen (PSA) recurrence (PSA \u22650.2 ng\/mL) or receipt of postoperative radiation. Secondary outcomes included time to metastases, urinary continence, and erectile function.\nResults: Of 193 consecutive patients, 121 (62%) received bilateral NS, 37 (19%) received unilateral NS, and 35 (18%) bilateral WR. Patients undergoing any NS had lower preoperative PSA, tumor stage, and grade group compared to WR (all p&lt;0.05). Adjusting for these variables, risk of treatment failure was increased in patients who underwent NS compared to WR (hazard ratio [HR] 3.08, 95% confidence interval [CI] 1.43-6.66). Continence recovered more quickly after NS, but by 24 months post-RP, this difference was not significant (relative risk [RR] 1.05, 95% CI 0.95-1.15). Postoperative erectile function was better in patients receiving unilateral or bilateral NS (unilateral: 21%, bilateral: 59%, WR: 0%).\nConclusions: NS during RP was associated with higher risk of treatment failure, but better functional outcomes compared to WR. These results indicate that NS presents a tradeoff of outcomes that must be matched to individual patient\u2019s values and preferences.<\/jats:p>","DOI":"10.5489\/cuaj.9503","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:21:09Z","timestamp":1774948869000},"source":"Crossref","is-referenced-by-count":2,"title":["Long-term function and oncologic outcomes following nerve-spare or wide resection during radical prostatectomy"],"prefix":"10.5489","volume":"20","author":[{"given":"Ameeta L.","family":"Nayak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Pupulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsas","family":"Nagee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke T.","family":"Lavall\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjeeta","family":"Mallick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anathea S.","family":"Flaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Morash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilias","family":"Cagiannos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney H.","family":"Breau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3456","published-online":{"date-parts":[[2026,3,30]]},"container-title":["Canadian Urological Association Journal"],"original-title":[],"link":[{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/download\/9503\/6782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/download\/9503\/6781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T09:21:11Z","timestamp":1775035271000},"score":1,"resource":{"primary":{"URL":"https:\/\/cuaj.ca\/index.php\/journal\/article\/view\/9503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,3,30]]}},"URL":"https:\/\/doi.org\/10.5489\/cuaj.9503","relation":{},"ISSN":["1920-1214","1911-6470"],"issn-type":[{"value":"1920-1214","type":"electronic"},{"value":"1911-6470","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,30]]}}}