{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:48:02Z","timestamp":1787845682372,"version":"build-2784847793"},"reference-count":20,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Crit Care Med"],"abstract":"BACKGROUND<\/jats:p>\n Sepsis is associated with impaired tissue perfusion and elevated serum lactate, a key prognostic marker. Magnesium plays a vital role in cellular energy metabolism and may enhance lactate clearance in sepsis.<\/jats:p>\n AIM<\/jats:p>\n To investigate the impact of magnesium on the clearance of lactate in critically sick patients with sepsis.<\/jats:p>\n METHODS<\/jats:p>\n In this triple-blind, randomized trial, 138 adult patients with a diagnosis of sepsis (according to Sepsis-3 guidelines) and with serum lactate levels > 2 mmol\/L were randomized into the magnesium (M) group and the placebo (P) group. Randomization was performed using an online sequence generator. The individuals in group M were administered 2 g of magnesium sulphate infusion diluted in 50 mL of normal saline over 2 hours for 3 days. The individuals in group P were administered an identical volume of normal saline for three days. The primary outcome was to compare the time to lactate clearance (20% decrease from baseline) in both groups. The secondary outcomes included changes in lactate clearance, intensive care unit (ICU) duration, hospital stay, and 28-day mortality in both groups.<\/jats:p>\n RESULTS<\/jats:p>\n Time to 20% lactate clearance was considerably lower in the M group (5.73 \u00b1 2.19 hours) when compared to the P group (8.54 \u00b1 2.72 hours), with a mean difference [95% confidence interval (CI)]: -2.81 (-3.65 to -1.99), P < 0.001. Mean rise in lactate clearance was markedly more significant in M group than P group on day 1 [18.88% \u00b1 1.80% vs 12.61% \u00b1 1.94% respectively, with mean difference (95%CI): 6.26 (5.63-6.89), P < 0.001] on day 2 [30.02% \u00b1 4.30 % vs 23.34% \u00b1 4.76% respectively, with mean difference (95%CI): 6.68 (5.15-8.20), P < 0.001] and day 3 [50.74% \u00b1 6.06 % vs 37.94% \u00b1 4.53% respectively, with mean difference (95%CI): 12.80 (11.00-14.60), P < 0.001]. The length of ICU stay was considerably shorter in the M group, 8 (3-15) days, compared to the P group, 12 (5-19) days (P < 0.001). The duration of hospitalization was significantly decreased in the M group, 12 (4-24) days than in the P group, 16 (9-25) days (P < 0.001); however, the 28-day mortality was similar in both groups.<\/jats:p>\n CONCLUSION<\/jats:p>\n Magnesium supplementation was associated with shorter lactate clearance time and reduced ICU and hospital stay duration in patients with sepsis; however, the difference in 28-day mortality between the groups was statistically nonsignificant.<\/jats:p>","DOI":"10.5492\/wjccm.v15.i2.115389","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:50:24Z","timestamp":1779324624000},"source":"Crossref","is-referenced-by-count":1,"title":["Impact of magnesium on the clearance of lactate in critically sick patients with sepsis: Randomized clinical trial"],"prefix":"10.5492","volume":"15","author":[{"given":"Chakkaravarthe","family":"Anbarasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Kothari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanvi M","family":"Meshram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamlesh","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep K","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-23935"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.09.023"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4675-y"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.83017"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2021.2009125"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.07.029"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.160272"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1177\/0885066614530659"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.17179\/excli2017-182"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-018-0291-y"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcw048"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr2351w"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000769"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-019-02788-w"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-754089\/v1"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.18502\/aacc.v5i3.1207"},{"key":"B18","doi-asserted-by":"crossref","unstructured":"Patil PS, Aslam SS. 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