{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:45:36Z","timestamp":1789429536285,"version":"build-2803163510"},"reference-count":23,"publisher":"Baishideng Publishing Group Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Exp Med"],"abstract":"BACKGROUND<\/jats:p>\n Compared with patients with other causes of acute pancreatitis, those with hypertriglyceridemia-induced acute pancreatitis (HTG-AP) are more likely to develop persistent organ failure (POF). Therefore, recognizing the individuals at risk of developing POF early in the HTG-AP process is a vital for improving outcomes. Bedside index for severity in acute pancreatitis (BISAP), a simple parameter that is obtained 24 h after admission, is an ideal index to predict HTG-AP severity; however, the suboptimal sensitivity limits its clinical application. Hence, current clinical scoring systems and biochemical parameters are not sufficient for predicting HTG-AP severity.<\/jats:p>\n AIM<\/jats:p>\n To elucidate the early predictive value of red cell distribution width (RDW) for POF in HTG-AP.<\/jats:p>\n METHODS<\/jats:p>\n In total, 102 patients with HTG-AP were retrospectively enrolled. Demographic and clinical data, including RDW, were collected from all patients on admission.<\/jats:p>\n RESULTS<\/jats:p>\n Based on the Revised Atlanta Classification, 37 (33%) of 102 patients with HTG-AP were diagnosed with POF. On admission, RDW was significantly higher in patients with HTG-AP and POF than in those without POF (14.4% vs 12.5%, P < 0.001). The receiver operating characteristic curve demonstrated a good discriminative power of RDW for POF with a cutoff of 13.1%, where the area under the curve (AUC), sensitivity, and specificity were 0.85, 82.4%, and 77.9%, respectively. When the RDW was \u2265 13.1% and one point was added to the original BISAP to obtain a new BISAP score, we achieved a higher AUC, sensitivity, and specificity of 0.89, 91.2%, and 67.6%, respectively.<\/jats:p>\n CONCLUSION<\/jats:p>\n RDW is a promising predictor of POF in patients with HTG-AP, and the addition of RDW can promote the sensitivity of BISAP.<\/jats:p>","DOI":"10.5493\/wjem.v13.i5.115","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T01:21:05Z","timestamp":1702948865000},"page":"115-122","source":"Crossref","is-referenced-by-count":5,"title":["Red cell distribution width: A predictor of the severity of hypertriglyceridemia-induced acute pancreatitis"],"prefix":"10.5493","volume":"13","author":[{"given":"Yong-Cai","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Hua","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2023,12,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.27"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpa.0000236733.31617.52"},{"key":"B3","unstructured":"Guo YY, Li HX, Zhang Y, He WH. Hypertriglyceridemia-induced acute pancreatitis: progress on disease mechanisms and treatment modalities. Discov Med 2019; 27: 101-109"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000069"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.4558"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i39.14450"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.06.61"},{"key":"B8","doi-asserted-by":"crossref","unstructured":"\u015eenol K, Saylam B, Kocaay F, Tez M. Red cell distribution width as a predictor of mortality in acute pancreatitis. 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