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Pregnancy induces increased insulin resistance due to physiological changes in hormonal and metabolic homeostasis. Inadequate compensation by islet beta-cells results in hyperglycemia. The standard oral glucose tolerance test at 24-28 wk of gestation sets the diagnosis. Accumulated evidence from prospective studies indicates a link between early pregnancy C-peptide levels and the risk of subsequent gestational diabetes. Elevated C-peptide levels and surrogate glycemic indices at the beginning of pregnancy could prompt appropriate strategies for secondary prevention.<\/jats:p>","DOI":"10.5493\/wjem.v14.i1.89320","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T09:43:46Z","timestamp":1710841426000},"source":"Crossref","is-referenced-by-count":4,"title":["Future clinical prospects of C-peptide testing in the early diagnosis of gestational 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