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MicroRNA-155 (miR-155)-induced translational repression of key cardiovascular (CV) genes (i.e., AT1R ) restrains SARS-CoV-2-engendered RAS hyperactivity to tolerable and SARS-CoV-2-protective CV phenotypes supporting a protective erythropoietin (EPO) evolutionary landscape. MiR-155\u2019s disrupted repression of the AT1R  1166C-allele associates with adverse CV and COVID-19 outcomes, confirming its decisive role in RAS modulation. RAS inhibition disrupts this miR-155-EPO network by further lowering EPO and miR-155 in COVID-19 with co-morbidities, thereby allowing unimpeded RAS hyperactivity to progress precariously. Current pharmacological interventions in COVID-19 employing RAS inhibition should consider these complex but potentially detrimental miR-155\/EPO-related effects.<\/jats:p>","DOI":"10.5493\/wjem.v15.i2.100748","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T07:35:38Z","timestamp":1744356938000},"source":"Crossref","is-referenced-by-count":1,"title":["MicroRNA-155 modulation by renin-angiotensin system inhibitors may underlie their enigmatic role in COVID-19"],"prefix":"10.5493","volume":"15","author":[{"given":"Konstantinos I","family":"Papadopoulos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Papadopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tar Choon","family":"Aw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-021-00168-0"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-024-01772-x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.4405"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00214-9"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-024-01682-y"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-023-00867-w"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-022-00819-w"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-024-01041-6"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26175399"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.08.102"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2021.103709"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2022.43.129.35014"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703424104"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-020-10010-z"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0887-9"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040607"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1159\/000439183"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s004249900238"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1159\/000507272"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000000088"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/532915"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29557"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27592"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18734"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.88942"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.12.009"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301913"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8080277"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2009.02.013"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24403"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000491"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90333.2008"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202203_28217"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-024-00599-4"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-57871-9"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0301056"}],"container-title":["World Journal of Experimental Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2220-315X\/full\/v15\/i2\/100748.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2220-315X\/full\/v15\/i2\/100748.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T07:35:48Z","timestamp":1744356948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2220-315X\/full\/v15\/i2\/100748.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":36,"journal-issue":{"issue":"2"},"alternative-id":["100748"],"URL":"https:\/\/doi.org\/10.5493\/wjem.v15.i2.100748","relation":{},"ISSN":["2220-315X"],"issn-type":[{"value":"2220-315X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,20]]}}}