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Biochemical Engineering and Biotechnology Handbook. 2nd ed USA: Stockton Press; 1991;1059-1110."},{"key":"ref110","unstructured":"Lim JAC, Patkar A, McDonagh G, Sinclair A, Lucy P. Modeling bioprocess cost: the economic benefits of expression technology based on Pseudomonas fluorescens. Bioprocess Intnl 2010;8:62-70."},{"key":"ref111","doi-asserted-by":"crossref","unstructured":"Lapkin AA, Plucinski PK, Cutler M. Comparative assessment of technologies for extraction of artemisinin. J Nat Prod 2006;69:1653-1664.","DOI":"10.1021\/np060375j"},{"key":"ref112","unstructured":"Griffee P, Diemer P. Artemisia annua; the plant, production, processing and medicinal applications. Food and Agriculture Organization of the United Nations. Available from: http: \/\/ecoport.org\/ep?SearchType=earticleView&earticleId=727&page=2#section5675<\/ext-link>."},{"key":"ref113","unstructured":"Sipler D, Weathers PJ. Artemisia annua as a high value crop and weed control. 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GAP Good Agricultural Practices (GAP). Cited: 2014-05-25. Available from: http: \/\/www.uky.edu\/Ag\/CCD\/introsheets\/gap.pdf<\/ext-link>."},{"key":"ref122","unstructured":"Charman SA. GAP Comparison of gaps governing the growing and harvesting of fresh produce. Cited: 2014-05-27. Available from: http:\/\/www.pewhealth.org\/uploadedFiles\/PHG\/Content_Level_Pages\/Reports\/PSP-RPT-GAP-Governing-Fresh-Produce.pdf<\/ext-link>."},{"key":"ref123","unstructured":"World Health Organization. WHO monograph on good agricultural and collection practices (GACP) for Artemisia annua L. Available from: http: \/\/www.who.int\/malaria\/publications\/atoz\/9241594438\/en\/<\/ext-link>."},{"key":"ref124","unstructured":"World Health Organization. WHO guidelines on good agricultural and collection practices (GACP) for medicinal plants. Available from: http: \/\/whqlibdoc.who.int\/publications\/2003\/9241546271.pdf<\/ext-link>."},{"key":"ref125","unstructured":"World Health Organization. WHO guidelines for assessing quality of herbal medicines with reference to contaminants and residues. Available from: http: \/\/apps.who.int\/medicinedocs\/documents\/s14878e\/s14878e.pdf<\/ext-link>."},{"key":"ref126","doi-asserted-by":"crossref","unstructured":"Marchand E, Atemnkeng MA, Vanermen S, Plaizier-Vercammen J. Development and validation of a simple thin layer chromatographic method for the analysis of artemisinin in Artemisia annua L. plant extracts. Biomed Chromatogr 2008;22:454-459.","DOI":"10.1002\/bmc.953"},{"key":"ref127","doi-asserted-by":"crossref","unstructured":"Koobkokkruad T, Chochai A, Kerdmanee C, De-Eknamkul W. TLC-densitometric analysis of artemisinin for the rapid screening of high-producing plantlets of Artemisia annua L. Phytochem Anal 2007;18:229-234.","DOI":"10.1002\/pca.976"},{"key":"ref128","unstructured":"Arvouet-Grand A, Vennat B, Pourrat A, Legret P. [Standardization of propolis extract and identification of principal constituents]. J Pharm Belg 1994;49:462-468."},{"key":"ref129","doi-asserted-by":"publisher","DOI":"10.1086\/591195"},{"key":"ref130","unstructured":"Efferth T. Artemisinin: a versatile weapon from traditional Chinese medicine. Herbal drugs: ethnomedicine to modern medicine Heidelberg: Springer Verlag; 2009;179-194."},{"key":"ref131","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2011.06.008"},{"key":"ref132","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399409001239"},{"key":"ref133","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.01.033"},{"key":"ref134","doi-asserted-by":"publisher","DOI":"10.2174\/0929867013371581"},{"key":"ref135","doi-asserted-by":"crossref","unstructured":"Avery MA, Muraleedharan KM, Desai PV, Bandyopadhyaya AK, Furtado MM, Tekwani BL. Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria. J Med Chem 2003;46:4244-4258.","DOI":"10.1021\/jm030181q"},{"key":"ref136","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47364-0"},{"key":"ref137","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01544-06"},{"key":"ref138","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-011-2418-0"},{"key":"ref139","unstructured":"World Health Organization. The 17 neglected tropical diseases. Available from: http: \/\/www.who.int\/neglected_diseases\/diseases\/en\/<\/ext-link>."},{"key":"ref140","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr038"},{"key":"ref141","doi-asserted-by":"crossref","unstructured":"Kamya MR, Gasasira AF, Yeka A, Bakyaita N, Nsobya SL, Francis D, Rosenthal PJ, Dorsey G, Havlir D. Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study. J Infect Dis 2006;193:9-15.","DOI":"10.1086\/498577"},{"key":"ref142","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis234"},{"key":"ref143","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60851-X"},{"key":"ref144","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.03.024"},{"key":"ref145","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-84"}],"container-title":["World Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.wjgnet.com\/2220-3192\/full\/v3\/i4\/39.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T16:02:26Z","timestamp":1717603346000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/2220-3192\/full\/v3\/i4\/39.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":145,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.5497\/wjp.v3.i4.39","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.739879813.793594210","asserted-by":"object"}]},"ISSN":["2220-3192"],"issn-type":[{"value":"2220-3192","type":"print"}],"subject":[],"published":{"date-parts":[[2014]]}}}