{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:02:56Z","timestamp":1757455376573},"reference-count":39,"publisher":"Baishideng Publishing Group Inc.","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Psychiatry"],"abstract":"<jats:p>A condition of exposure to multiple stressors resulting in a mixed clinical picture spanning conventional categories without meeting any of them in full, encompasses a risk for a list of comorbidities preventing appropriate prevention and treatment. New transformative transdiagnostic approaches suggest changes spanning conventional categories. They base their systems of classification on biomarkers as well as on brain structural and functional dysregulation as associated with behavioral and emotional symptoms. These new approaches received critiques for not being specific enough and for suggesting a few biomarkers for psychopathology as a whole. Therefore, they put the value of differential diagnosis at risk of avoiding appropriate derived prevention and treatment. Multiplicity of stressors has been considered mostly during and following catastrophes, without considering the resulting mixed clinical picture and life event concomitant stressors. We herewith suggest a new category within the conventional classification systems: The Complex Stress Reaction Syndrome, for a condition of multiplicity of stressors, which showed a mixed clinical picture for daily life in the post coronavirus disease 2019 era, in the general population. We argue that this condition may be relevant to daily, regular life, across the lifespan, and beyond conditions of catastrophes. We further argue that this condition may worsen without professional care and it may develop into a severe mental health disorder, more costly to health systems and the suffering individuals. Means for derived prevention and treatment are discussed. <\/jats:p>","DOI":"10.5498\/wjp.v13.i7.423","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T08:20:40Z","timestamp":1689668440000},"page":"423-434","source":"Crossref","is-referenced-by-count":2,"title":["Population-based affective-disorder-related biomedical\/biophysical multi-hyper-morbidity across the lifespan: A 16-year population study"],"prefix":"10.5498","volume":"13","author":[{"given":"David R L","family":"Cawthorpe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2023,7,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2019.05.015"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7176.219655"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/13546805.2015.1014031"},{"key":"B4","unstructured":"Ku\u010dukali\u0107 A, Bravo-Mehmedba\u0161i\u0107 A, Kulenovi\u0107 AD. Frequency of bipolar affective disorder in patients with major depressive episode with or without psychiatric co-morbid disorders. Psychiatr Danub 2012; 24 Suppl 3: S321-S325"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7176.106036"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/36.3.219"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.v62n0305"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/s0165-0327(98)00095-0"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.06.020"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.12788\/fp.0106"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.apnu.2020.04.013"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1177\/0091217417749795"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s11126-020-09831-5"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnab102."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019011"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1177\/2470547019875116"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3999(02)00352-5"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/12-081"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/11-149"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/14-120"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00635"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2018.5"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2020.0349"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0000000000000270"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20070"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.7812\/TPP\/02.994"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2020.104797"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1037\/amp0000763"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1037\/amp0000809"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440x(81)90051-1"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1984.01790210041006"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/BF00805795"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1017\/S092427080003550X"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1177\/00912174211007675"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2012.11.003"},{"key":"B36","unstructured":"Ramasubbu R, Beaulieu S, Taylor VH, Schaffer A, McIntyre RS; Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force. The CANMAT task force recommendations for the management of patients with mood disorders and comorbid medical conditions: diagnostic, assessment, and treatment principles. Ann Clin Psychiatry 2012; 24: 82-90"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00138.x"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12888"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/wps.21055"}],"container-title":["World Journal of Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2220-3206\/full\/v13\/i7\/423.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2220-3206\/full\/v13\/i7\/423.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T08:20:54Z","timestamp":1689668454000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2220-3206\/full\/v13\/i7\/423.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,19]]},"references-count":39,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.5498\/wjp.v13.i7.423","relation":{},"ISSN":["2220-3206"],"issn-type":[{"value":"2220-3206","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7,19]]}}}