{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:04:46Z","timestamp":1772795086197,"version":"3.50.1"},"reference-count":37,"publisher":"Baishideng Publishing Group Inc.","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Psychiatry"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Blonanserin (BNS) is a well-tolerated and effective drug for treating schizophrenia.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To investigate which types of patients would obtain the most benefit from BNS treatment.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>A total of 3306 participants were evaluated in a 12-week, prospective, multicenter, open-label post-marketing surveillance study of BNS. Brief psychiatric rating scale (BPRS) scores were calculated to evaluate the effectiveness of BNS, and its safety was assessed with the incidence of adverse drug reactions. Linear regression was used to screen the influencing factors for the reduction of BPRS total score, and logistic regression was used to identify patients with a better response to BNS.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>The baseline BPRS total score (48.8 \u00b1 15.03) decreased to 27.7 \u00b1 10.08 at 12 weeks (P  &lt; 0.001). Extrapyramidal symptoms (14.6%) were found to be the most frequent adverse drug reactions. The acute phase, baseline BPRS total score, current episode duration, number of previous episodes, dose of concomitant antipsychotics, and number of types of sedative-hypnotic agents were found to be independent factors affecting the reduction of BPRS total score after treatment initiation. Specifically, patients in the acute phase with baseline BPRS total score \u2265 45, current episode duration &lt; 3 months, and \u2264 3 previous episodes derived greater benefit from 12-week treatment with BNS.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>Patients in the acute phase with more severe symptoms, shorter current episode duration, fewer previous episodes, and a lower psychotropic drug load derived the greatest benefit from treatment with BNS.<\/jats:p>","DOI":"10.5498\/wjp.v14.i11.1735","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T03:39:08Z","timestamp":1730950748000},"page":"1735-1745","source":"Crossref","is-referenced-by-count":1,"title":["Who can benefit more from its twelve-week treatment: A prospective cohort study of blonanserin for patients with 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