{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:23:24Z","timestamp":1772213004958,"version":"3.50.1"},"reference-count":35,"publisher":"Baishideng Publishing Group Inc.","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Psychiatry"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Cervical spondylosis (CS) frequently co-occurs with generalized anxiety disorder (GAD), presenting a complex clinical challenge. Managing CS-related pain in patients with GAD is particularly challenging because of the bidirectional relationship between pain and anxiety, necessitating integrated treatment strategies.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To evaluate the efficacy of electroacupuncture (EA) in treating CS-related pain and anxiety in patients with GAD.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>This retrospective cohort study analyzed data from 83 patients with CS-related pain and GAD who received EA treatment over 2-year period. Pain intensity was assessed using the visual analog scale, and anxiety symptoms were measured using the Hamilton Anxiety Rating Scale. Additionally, neuroinflammatory markers, including interleukin-6, tumor necrosis factor-alpha, and high-sensitivity C-reactive protein, were examined. Outcomes were evaluated at baseline, after 4 weeks, and after 8 weeks of treatment.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>EA treatment significantly reduced CS-related pain (mean visual analog scale reduction: 3.24 \u00b1 1.18; P  &lt; 0.001) and improved anxiety symptoms (mean Hamilton Anxiety Rating Scale reduction: 7.83 \u00b1 2.65; P  &lt; 0.001) after 8 weeks of treatment. Neuroinflammatory markers also showed significant reductions, with interleukin-6 and tumor necrosis factor-alpha levels decreasing by 32.7% and 28.5%, respectively (P  &lt; 0.01). Pain reduction was significantly correlated with improvements in anxiety symptoms (r  = 0.68; P  &lt; 0.001) and a decrease in inflammatory markers (r  = 0.54; P  &lt; 0.01).<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>EA demonstrates significant efficacy in reducing CS-related pain in patients with comorbid GAD, along with concurrent improvements in anxiety symptoms and neuroinflammatory profiles. These findings suggest that EA may offer a valuable integrative approach for managing this complex clinical presentation, potentially addressing both pain and anxiety through the modulation of neuroinflammatory pathways.<\/jats:p>","DOI":"10.5498\/wjp.v15.i11.108288","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:33:51Z","timestamp":1761870831000},"source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of electroacupuncture for cervical spondylosis-related pain in patients with generalized anxiety disorder"],"prefix":"10.5498","volume":"15","author":[{"given":"Zhe","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Hui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1177\/21925682221075290"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1177\/2192568220948832"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2022.07.003"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.31616\/asj.2022.0440"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11030365"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000003056"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2021.03.031"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9936981"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1177\/070674370204701004"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.5"},{"key":"B11","unstructured":"Lin JG, Kotha P, Chen YH. Understandings of acupuncture application and mechanisms. Am J Transl Res 2022; 1469-1481"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3479"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1451342"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-045961"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1177\/0964528420920303"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.113627"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19169904"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2019.09.010"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/1523834"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-024-01267-x"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbmt.2021.10.012"},{"key":"B22","doi-asserted-by":"crossref","unstructured":"Atalay SG, Durmus A, Gezginaslan \u00d6. The Effect of Acupuncture and Physiotherapy on Patients with Knee Osteoarthritis: A Randomized Controlled Study. Pain Physician 2021; E269-E278","DOI":"10.36076\/ppj.2021\/24\/E269"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12526"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000030076"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000031515"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6429836"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000026871"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1177\/0964528420922232"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e30819"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlab046"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurom.2022.02.001"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X15666171123201142"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1124\/pr.113.008144"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002740"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20081"}],"container-title":["World Journal of Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2220-3206\/full\/v15\/i11\/108288.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2220-3206\/full\/v15\/i11\/108288.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:34:02Z","timestamp":1761870842000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2220-3206\/full\/v15\/i11\/108288.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":35,"journal-issue":{"issue":"11"},"alternative-id":["108288"],"URL":"https:\/\/doi.org\/10.5498\/wjp.v15.i11.108288","relation":{},"ISSN":["2220-3206"],"issn-type":[{"value":"2220-3206","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,19]]}}}