{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:44:14Z","timestamp":1761871454187,"version":"build-2065373602"},"reference-count":8,"publisher":"Baishideng Publishing Group Inc.","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Psychiatry"],"abstract":"<jats:p>This letter provides a critical appraisal of the comprehensive meta-analysis by Hou et al , which synthesizes the incidence and risk factors for postoperative delirium (POD) in organ transplant recipients. Their work establishes a pooled POD incidence of 20%, with significant variability across organ types (lung 34%, liver 22%, kidney 6%), and identifies key risk factors including primary graft dysfunction, hepatic encephalopathy, and high model for end-stage liver disease\/acute physiology and chronic health evaluation II scores. This commentary acknowledges the study's strength in providing a robust, trans-organ synthesis of current evidence. However, it critically discusses the substantial heterogeneity, the counterintuitive non-significance of age as a risk factor, and the unavoidable limitation of unmeasured confounders inherent in meta-analyses, such as preoperative cognitive\/psychiatric status and anesthetic protocols. While the findings provide an essential evidence base for risk stratification and prevention, this letter argues that the high heterogeneity underscores the need for organ-specific analysis and calls for large-scale, prospective studies with standardized protocols to translate these findings into reliable clinical prediction tools and targeted interventions.<\/jats:p>","DOI":"10.5498\/wjp.v15.i11.113121","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:33:51Z","timestamp":1761870831000},"source":"Crossref","is-referenced-by-count":0,"title":["Synthesizing the risk of postoperative delirium in organ transplantation"],"prefix":"10.5498","volume":"15","author":[{"given":"Haewon","family":"Byeon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s40472-021-00326-1"},{"key":"B2","unstructured":"Liang X, Ou ZY, Miao Y. [Research progress of delirium after solid organ transplantation]. Qiguan Yizhi 2024; 958-963"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v15.i7.104812"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202104_25733"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S254920"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60688-1"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-017-4204-x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.7779"}],"container-title":["World Journal of Psychiatry"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2220-3206\/full\/v15\/i11\/113121.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2220-3206\/full\/v15\/i11\/113121.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:34:36Z","timestamp":1761870876000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2220-3206\/full\/v15\/i11\/113121.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":8,"journal-issue":{"issue":"11"},"alternative-id":["113121"],"URL":"https:\/\/doi.org\/10.5498\/wjp.v15.i11.113121","relation":{},"ISSN":["2220-3206"],"issn-type":[{"value":"2220-3206","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,19]]}}}