{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:25:27Z","timestamp":1780543527481,"version":"3.54.1"},"reference-count":38,"publisher":"Baishideng Publishing Group Inc.","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Psychiatry"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Fear-related disorders, such as post-traumatic stress disorder (PTSD), significantly impact patients and families. Exposure therapy is a common treatment, but improving its effectiveness remains a key challenge. Fear conditioning and extinction in animal models offer insights into its mechanisms. Our previous research indicates that DNA methyltransferases play a role in fear memory renewal.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To investigate the role of DNA methylation in the extinction of fear memory, with the goal of identifying potential strategies to enhance the efficacy of exposure therapy for fear-related disorders.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>This study investigated the role of DNA methylation in fear memory extinction in mice. DNA methylation was manipulated using N-phthalyl-L-tryptophan (RG108) to reduce methylation and L-methionine injections to enhance it. Neuronal activity, and dendritic spine density was measured following extinction training.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>RG108 suppressed extinction, reduced spine density, and inhibited neuronal activity. Methionine injections facilitated extinction.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>DNA methylation is crucial for fear memory extinction. Enhancing methylation may improve the efficacy of exposure therapy, offering a potential strategy to treat fear-related disorders.<\/jats:p>","DOI":"10.5498\/wjp.v15.i7.107524","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:52:46Z","timestamp":1752108766000},"source":"Crossref","is-referenced-by-count":2,"title":["DNA methylation regulates the extinction of fear 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