{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:18:23Z","timestamp":1769728703973,"version":"3.49.0"},"reference-count":30,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Psychiatry"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Anxiety and depression are significant contributors to adverse outcomes in patients with colon cancer (CC). Therefore, investigating the key determinants of this psychological distress in such patients is essential.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To examine the correlation of anxiety\/depression status with stress-related markers and cancer-related fatigue (CRF), along with associated risk factors in patients with CC.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>The study enrolled 120 patients with CC treated at the Affiliated Yongchuan Hospital of Chongqing Medical University between February 2022 and February 2025. Initially, patients\u2019 anxiety [Self-Rating Anxiety Scale (SAS)] and depression [Self-Rating Depression Scale (SDS)] status were assessed first and then stratified into the anxiety\/depression group (n  = 62, SAS \u2265 50 or SDS \u2265 53) and control group (n  = 58). Comparative assessments were conducted for stress-related markers [heat shock protein 70 (HSP70) and C-reactive protein (CRP)] and CRF [Brief Fatigue Inventory-Chinese version (BFI-C)] at three measurement time points: Preoperative (T0), postoperative day 3 (T1), and postoperative day 7 (T2). Correlations between anxiety\/depression status and HSP70, CRP, and BFI-C in patients with CC were analyzed using Pearson\u2019s method, whereas univariate and multivariate regression identified independent predictors of anxiety or depressive symptoms in such patients.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>The analysis revealed prevalence rates of 30.00% for anxiety and 38.33% for depression among the 120 patients with CC, of whom 51.67% exhibited either condition, and 16.67% showed comorbidity. Both groups showed an initial increase in HSP70, CRP, and BFI-C followed by a decrease compared with those at T0, with the anxiety\/depression group exhibiting markedly higher levels of HSP70, CRP, and BFI-C at T1 and T2. Subsequent correlation analysis revealed strong positive correlations between SAS and SDS scores and HSP70, CRP, and BFI-C concentrations. Univariate analysis identified sex, age, marital status, monthly household income, tumor stage, and comorbidities as factors closely associated with anxiety or depression. Multivariate analysis further established female sex [odds ratio (OR) = 2.755], age \u2265 60 years (OR = 2.649), and advanced tumor stage (III-IV, OR = 2.349) as independent predictors of anxiety or depression in patients with CC.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>A subset of patients with CC exhibits anxiety and depressive symptoms, which are significantly positively correlated with stress-related markers and CRF. Moreover, patients with CC, female patients, those aged 60 years or older, and patients diagnosed with stage III-IV tumors are more prone to anxiety or depression.<\/jats:p>","DOI":"10.5498\/wjp.v16.i2.111196","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:46:39Z","timestamp":1769687199000},"source":"Crossref","is-referenced-by-count":0,"title":["Correlation of anxiety\/depression status with stress-related markers and cancer-related fatigue in patients with colon cancer"],"prefix":"10.5498","volume":"16","author":[{"given":"Ling","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Jian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duan-Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.79583"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.37563"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16081530"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.JNMS.2022_89-310"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2022.12.003"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.17116\/kurort20241010625"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-99493-9"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00865-6"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000942"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16061108"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v16.i7.2119"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000002323"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1177\/14574969241228510"},{"key":"B14","unstructured":"Wang P, Pang X, He M, Liu J. 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