{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:15:25Z","timestamp":1788318925979,"version":"build-2803163510"},"reference-count":24,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Transplant"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Kidney transplantation is the treatment of choice for end-stage renal disease. Whether propofol-based total intravenous anaesthesia (TIVA) confers advantages over volatile anaesthesia for perioperative stability, recovery, and graft outcomes remains debated.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To synthesise the currently available comparative evidence on propofol-based TIVA versus volatile anaesthesia in adult kidney transplantation\u2014focusing on haemodynamic stability, renal injury biomarkers, early graft function, recovery, postoperative nausea and vomiting (PONV), immunologic outcomes, and safety\u2014and to identify the key evidence gaps and priorities for future research.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>We performed a narrative review following the Scale for the Assessment of Narrative Review Articles framework, with structured search and selection consistent with PRISMA-S reporting. PubMed\/MEDLINE, EMBASE, Cochrane CENTRAL, Scopus, and Web of Science were searched from inception to February 2026. Quality was appraised using Cochrane Risk of Bias 2 and ROBINS-I. Six studies were directly eligible in adult kidney transplant recipients; four supplementary mechanistic sources informed interpretation.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>TIVA provided haemodynamic stability and immediate graft function equivalent to volatile anaesthesia. Urinary tubular biomarkers (kidney injury molecule-1, N-acetyl-\u03b2-D-glucosaminidase) were modestly lower with propofol in the VAPOR-1 trial (n  = 57 living-donor pairs), but this did not translate into differences in delayed graft function, serum creatinine, or one-year graft survival. TIVA was associated with faster extubation and lower PONV, though recovery comparisons were confounded by opioid co-administration. Acute rejection rates did not differ significantly.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>Propofol-based TIVA is a safe and effective alternative to volatile anaesthesia in kidney transplantation. Whether the cellular-level biomarker signal translates into clinically meaningful renoprotection in higher-risk grafts requires adequately powered multicentre trials with standardised perioperative protocols.<\/jats:p>","DOI":"10.5500\/wjt.121739","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:49:47Z","timestamp":1785246587000},"source":"Crossref","is-referenced-by-count":0,"title":["Total intravenous anesthesia in kidney transplantation: A narrative review"],"prefix":"10.5500","volume":"16","author":[{"given":"Ervandy","family":"Rangganata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanita","family":"Castellanos De Brigard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apostolos","family":"Prionas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagy","family":"Habib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios E","family":"Papalois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03622-6"},{"key":"B2","unstructured":"Modesti C, Sacco T, Morelli G, Bocci MG, Ciocchetti P, Vitale F, Perilli V, Sollazzi L. Balanced anestesia versus total intravenous anestesia for kidney transplantation. Minerva Anestesiol 2006; 627-635"},{"key":"B3","unstructured":"Lee JH, Joo DJ, Kim JM, Park JH, Kim YS, Koo BN. Preconditioning effects of the anesthetic administered to the donor on grafted kidney function in living donor kidney transplantation recipients. Minerva Anestesiol 2013; 504-514"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010253"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199805000-00006"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.01.007"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.11.018"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2022.02.030"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5629371"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex057"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-020-01190-9"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/s0041-1345(98)00033-5"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2020.02.012"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/s41073-019-0064-8"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-020-01542-z"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn667"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200004000-00035"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1112-5"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.10.1348"},{"key":"B23","unstructured":"Sklar GE. Propofol and postoperative infections. Ann Pharmacother 1997; 1521-1523"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu313"}],"container-title":["World Journal of Transplantation"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2220-3230\/full\/v16\/i3\/121739.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2220-3230\/full\/v16\/i3\/121739.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:44:50Z","timestamp":1788317090000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2220-3230\/full\/v16\/i3\/121739.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":24,"journal-issue":{"issue":"3"},"alternative-id":["121739"],"URL":"https:\/\/doi.org\/10.5500\/wjt.121739","relation":{},"ISSN":["2220-3230"],"issn-type":[{"value":"2220-3230","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,18]]}}}