{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:28:44Z","timestamp":1773098924722,"version":"3.50.1"},"reference-count":104,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Transplant"],"abstract":"<jats:p>Liver transplantation (LT) provides a life-saving option for cirrhotic patients with complications and hepatocellular carcinoma. Despite the increasing number of liver transplants performed each year, the number of LT candidates on the waitlist remains unchanged due to an imbalance between donor organ supply and the demand which increases the waitlist time and mortality. Living donor liver transplant had a great role in increasing the donor pool and shortened waitlist time for LT candidates. Nevertheless, further strategies can be implemented to increase the pool of potential donors in deceased donor LT, such as reducing the rate of organ discards. Utilizing hepatitis C virus (HCV) seropositive liver grafts is one of the expanded donor organ criteria. A yearly increase of hundreds of transplants is anticipated as a result of maximizing the utilization of HCV-positive organs for HCV-negative recipients. Direct-acting antiviral therapy's efficacy has revolutionized the treatment of HCV infection and the use of HCV-seropositive donors in transplantation. The American Society of Transplantation advises against performing transplants from HCV-infected liver donors (D+) into HCV-negative recipient (R-) unless under Institutional Review Board-approved study rules and with full informed consent of the knowledge gaps associated with such transplants. Proper selection of patients to be transplanted with HCV-infected grafts and confirming their access to direct-acting antivirals if needed is important. National and international consensuses are needed to regulate this process to ensure the maximum benefit and the least adverse events.<\/jats:p>","DOI":"10.5500\/wjt.v14.i2.90382","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T10:37:04Z","timestamp":1718275024000},"source":"Crossref","is-referenced-by-count":1,"title":["Expanding the liver donor pool worldwide with hepatitis C infected livers, is it the time?"],"prefix":"10.5500","volume":"14","author":[{"given":"Mai","family":"Hashem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A","family":"Medhat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doaa","family":"Abdeltawab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahed A","family":"Makhlouf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.04.005"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30349-8"},{"key":"B3","unstructured":"United Network for Organ Sharing (UNOS).   Data. UNOS Web site. Available from https:\/\/unos.org\/data\/"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.21608\/gg.2023.201627.1002"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.11.045"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2020.00014"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27283"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14381"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15674"},{"key":"B10","unstructured":"NHS Blood and Transplant.   Organ donation and transplantation. Available from: https:\/\/www.nhsbt.nhs.uk\/what-we-do\/transplantation-services\/organ-donation-and-transplantation\/"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2742"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/cld.222"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23396"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.20387.1"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31551"},{"key":"B16","unstructured":"The American Association for the Study of Liver Diseases and the Infectious Diseases Society of America.   AASLD\/IDSA HCV guidance panel. Recommendations for testing, managing, and treating hepatitis C. Updated August 27, 2020. Available from: https:\/\/www.hcvguidelines.org\/references\/aasldidsa-2020"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13731"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2005.08.004"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.02126.x"},{"key":"B20","unstructured":"U.S. Food and Drug Administration. FDA approves Incivek for hepatitis C.  Updated May 23, 2011. Available from: https:\/\/www.prnewswire.com\/news-releases\/fda-approves-incivek-for-hepatitis-c-122441703.html"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1214853"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306218"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12982"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30540"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1172\/JCI127203"},{"key":"B27","unstructured":"Policies - OPTN.   Available from: https:\/\/optn.transplant.hrsa.gov\/policies-bylaws\/policies\/"},{"key":"B28","unstructured":"Organ Procurement and Transplantation Network (OPTN).   Deceased Donor Organ Procurement (Policy 2). 2023; 22\u201334. Available from: https:\/\/optn.transplant.hrsa.gov\/media\/eavh5bf3\/optn_policies.pdf"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29704"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1177\/003335491312800403"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.6002\/ect.2012.0158"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.005"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13761"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25741"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxab207"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14386"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2021.100318"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2018.12.004"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40010010.x"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2001.00280.x"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.7.724"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13283"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290311"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1086\/428578"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22706"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1086\/508198"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.31870"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-022-02107-1"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15162"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13194"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15768"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31011"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25925"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-5404-x"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000234896.18207.fa"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000183973.49899.b1"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.04.009"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12103"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/cld.743"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29572"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.03.015"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000479"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30268-1"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2020.100528"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/cld.849"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003014"},{"key":"B67","unstructured":"Demetris AJ, Crawford JM, Isse K, Minervini MI, Nalesnik MA, Rubin E, Randhawa PS, Sasatomi E.   Pathology of Liver and Hematopoietic Stem Cell Transplantation. In: Odze RD, Goldblum JR, editors. Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas. 3rd ed. Philadelphia: Elsevier, 2015: 1408-1461"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030770"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24838"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22172"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002196"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29219"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.030"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1159\/000495263"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27950"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12877"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad319"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2018.02.015"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1177\/0897190017731245"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30046"},{"key":"B81","unstructured":"Durand C, Brown D, Wesson R, Bhair N, Naqvi F, Ostrander D, Bowring M, Massie A, Rasmussen S, Sugarman J, Segev D, Sulkowski M, Desai N.   EXPANDER-1: Exploring Renal Transplants Using Hepatitis-C Infected Donors for HCV-Negative Recipients. Updated April 30, 2017. Available from: https:\/\/atcmeetingabstracts.com\/abstract\/expander-1-exploring-renal-transplants-using-hepatitis-c-infected-donors-for-hcv-negative-recipients\/"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.04.003"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1002\/lt.25072"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.08.042"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29723"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-016-0551-z"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.1996.v23.pm0008550046"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12760"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2004.00654.x"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12737"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.06.063"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500010104"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.07.035"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000198"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318219eb8f"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16565"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22175"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199811150-00023"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.04.022"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15583"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.25107\/2638-4558.1439"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31185"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2020.1758065"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14281"}],"container-title":["World Journal of Transplantation"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2220-3230\/full\/v14\/i2\/90382.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2220-3230\/full\/v14\/i2\/90382.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T10:37:15Z","timestamp":1718275035000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2220-3230\/full\/v14\/i2\/90382.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":104,"journal-issue":{"issue":"2"},"alternative-id":["90382"],"URL":"https:\/\/doi.org\/10.5500\/wjt.v14.i2.90382","relation":{},"ISSN":["2220-3230"],"issn-type":[{"value":"2220-3230","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,18]]}}}