{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:55:37Z","timestamp":1787241337814,"version":"build-2736575974"},"reference-count":33,"publisher":"Baishideng Publishing Group Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Transplant"],"abstract":"BACKGROUND<\/jats:p>\n In the absence of effective antimicrobials, transplant surgery is not viable, and antirejection immunosuppressants cannot be administered, as resistant infections compromise the life-saving goal of organ transplantation.<\/jats:p>\n AIM<\/jats:p>\n To evaluate the efficacy of antimicrobials in preventing resistance in solid organ transplant recipients.<\/jats:p>\n METHODS<\/jats:p>\n A systematic review was conducted using a search methodology consistent with the preferred reporting items for systematic reviews and meta-analyses. This review included randomized clinical trials that evaluated the efficacy of antimicrobial agents (prophylactic or therapeutic) aimed at preventing antimicrobial resistance. The search strategy involved analyzing multiple databases, including PubMed\/MEDLINE, Web of Science, EMBASE, Scopus, and SCIELO, as well as examining gray literature sources on Google Scholar. A comprehensive electronic database search was conducted from the databases\u2019 inception until May 2024, with no language restrictions.<\/jats:p>\n RESULTS<\/jats:p>\n After the final phase of the eligibility assessment, this systematic review ultimately included 7 articles. A total of 2318 patients were studied. The most studied microorganisms were cytomegalovirus, although vancomycin-resistant enterococci, Clostridioides difficile , and multidrug-resistant Enterobacterales were also analyzed. The antimicrobials used in the interventions were mainly maribavir, valganciclovir, ganciclovir, and colistin-neomycin. Of concern, all clinical trials showed significant proportions of resistant microorganisms after the interventions, with no statistically significant differences between the groups (mean resistance 13.47% vs 14.39%), except for two studies that demonstrated greater efficacy of maribavir and valganciclovir (mean resistance 22.2% vs 41.1% in the control group; P < 0.05). The total reported deaths in three clinical trials were 75, and there were 24 graft rejections in two studies.<\/jats:p>\n CONCLUSION<\/jats:p>\n All clinical trials reported significant proportions of antimicrobial-resistant microorganisms following interventions. More high-quality randomized clinical trials are needed to corroborate these results.<\/jats:p>","DOI":"10.5500\/wjt.v15.i1.98003","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T20:17:32Z","timestamp":1732565852000},"source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of antimicrobials in preventing resistance in solid organ transplant recipients: A systematic review of clinical trials"],"prefix":"10.5500","volume":"15","author":[{"given":"Carlos M","family":"Ardila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep K","family":"Yadalam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Ram\u00edrez-Arbelaez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.07.012"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-022-00778-1"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13851"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12984"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.41089"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13195"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.09.042"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/3930130"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14316"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.105906"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(95)00134-4"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab896"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab988"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.12.016"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy706"},{"key":"B16","doi-asserted-by":"crossref","unstructured":"Boivin G, Goyette N, Rollag H, Jardine AG, Pescovitz MD, Asberg A, Ives J, Hartmann A, Humar A. 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