{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:11:46Z","timestamp":1789773106230,"version":"4.0.1"},"reference-count":14,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Transplant"],"abstract":"BACKGROUND<\/jats:p>\n Tacrolimus (TAC) is metabolized primarily by the CYP3A -encoded enzyme family (CYP3A4 , CYP3A5 , and CYP3A7 ). Individuals expressing the CYP3A51 allele are considered fast metabolizers and generally require higher TAC doses to reach therapeutic levels.<\/jats:p>\n AIM<\/jats:p>\n To evaluate the predictive value of the TAC concentration-to-dose (C0\/D) ratio for identifying CYP3A5 polymorphisms in renal transplant recipients.<\/jats:p>\n METHODS<\/jats:p>\n Eighty-six de novo kidney transplant recipients with TAC-based immunosuppression from the Department of Nephrology and Dialysis at Military Hospital 103 (Hanoi, Vietnam) were included in this retrospective study. Blood samples were collected within the first week post-transplantation to monitor TAC levels and to perform genotyping for CYP3A5 genetic polymorphisms.<\/jats:p>\n RESULTS<\/jats:p>\n The CYP3A53\/3 genotype was identified in 37 patients (43%), CYP3A51\/3 in 40 patients (46.5%), and CYP3A51\/1 in 9 patients (10.5%). Patients carrying the CYP3A51\/3 or CYP3A51\/1 genotype, classified as fast metabolizers (CYP3A5 expressers), had significantly lower TAC C0 concentrations and C0\/D ratios compared to slow metabolizers (CYP3A53\/3 genotype) at multiple time points during follow-up (all P < 0.001). Notably, the TAC C0\/D ratio obtained on day 1 (0.91) was shown to predict CYP3A5 polymorphism with a sensitivity of 84.6% and a specificity of 84.6%.<\/jats:p>\n CONCLUSION<\/jats:p>\n This study demonstrates that the TAC C0\/D ratio provides a reliable predictive value for CYP3A5 polymorphisms, which can be used to individualize TAC dosing in renal transplant recipients in Vietnam and other low-income countries.<\/jats:p>","DOI":"10.5500\/wjt.v15.i2.103247","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:40:41Z","timestamp":1740098441000},"source":"Crossref","is-referenced-by-count":4,"title":["Predictive value of tacrolimus concentration\/dose ratio in first post-transplant week for CYP3A5<\/i>-polymorphism in kidney-transplant recipients"],"prefix":"10.5500","volume":"15","author":[{"given":"Pham-Thai","family":"Dung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang-Xuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen-Chi","family":"Tue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen-Huu","family":"Ben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen-Minh","family":"Phuong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan-Ngoc","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan-Ba","family":"Nghia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diem-Thi","family":"Van","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi-Thuy","family":"Dung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang-Trung","family":"Vinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Rostaing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham-Quoc","family":"Toan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra033540"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000640"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/petr.13494"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41397-019-0144-7"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.113"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111128"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.08.063"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2013.08.019"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-015-1990-0"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.06.028"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12480"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002920"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1159\/000502290"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.nefroe.2024.03.019"}],"container-title":["World Journal of Transplantation"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2220-3230\/full\/v15\/i2\/103247.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2220-3230\/full\/v15\/i2\/103247.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:42:51Z","timestamp":1740098571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2220-3230\/full\/v15\/i2\/103247.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":14,"journal-issue":{"issue":"2"},"alternative-id":["103247"],"URL":"https:\/\/doi.org\/10.5500\/wjt.v15.i2.103247","relation":{},"ISSN":["2220-3230"],"issn-type":[{"value":"2220-3230","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,18]]}}}