{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T06:28:35Z","timestamp":1763447315119,"version":"3.45.0"},"reference-count":16,"publisher":"Baishideng Publishing Group Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Transplant"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Corneal ulcers are a major cause of visual impairment in developing countries. In Indonesia, severe infective ulcers often require keratoplasty (KP) to preserve ocular integrity and improve outcomes.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To determine demographic, clinical and microbiological characteristics, complications, and KP outcomes in patients with moderate to severe infective corneal ulcers.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>A retrospective review was conducted on patients with moderate to severe infective corneal ulcers who underwent KP between January 1, 2018 and December 31, 2020, with a minimum follow-up period of 3 weeks at the Ocular Infection and Immunology clinic of a tertiary referral hospital in Jakarta. Data were extracted from medical records.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>A total of 99 eyes from 99 patients with a mean age of 41.7 \u00b1 16.2 years were included. Eight-nine eyes of corneal cases were located at the central cornea with &gt; 6 mm lesion size (forty-one eyes). The culture positivity rate was 33%, primarily composed of Staphylococcus epidermidis.  Eyeball integrity was maintained in all patients.  Mean uncorrected visual acuity (VA) before KP was 2.50 and improved to 2.04 after 3 months of follow-up. Twenty patients with a cornea that was kept transparent achieved a VA of 0.40. Complications after KP appeared in 60 eyes, while secondary glaucoma was the most common complication (28 eyes), followed by graft failure (24 eyes) and graft rejection (14 eyes).<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>Corneal ulcers are a common problem in Indonesia following eye trauma. Therapeutic and tectonic KP can preserve the integrity of the eyeball in moderate to severe cases, although complications are common.<\/jats:p>","DOI":"10.5500\/wjt.v15.i4.106380","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T06:22:42Z","timestamp":1763446962000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics and outcomes of keratoplasty in moderate to severe infective corneal ulcers"],"prefix":"10.5500","volume":"15","author":[{"given":"Lukman","family":"Edwar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dicky","family":"Budiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratna","family":"Sitompul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Made","family":"Susiyanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina La Distia","family":"Nora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia","family":"Aziza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramadhiana Maktazula","family":"Tuasikal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella Hafidha","family":"Badruddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"B1","unstructured":"Hong AR, Shute TS, Huang AJW.   Bacterial Keratitis. In: Mannis MJ, Holland EJ, editors. Cornea. 4th ed. Philadelphia: Elsevier, 2017: 875-901"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(17)30393-5"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305224"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.19080\/jojo.2017.03.555611"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8283131"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-10994-3"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2019.12.10"},{"key":"B8","unstructured":"Bharathi MJ, Ramakrishnan R, Vasu S; Meenakshi, Palaniappan R. Aetiological diagnosis of microbial keratitis in South India - a study of 1618 cases. Indian J Med Microbiol 2002; 19-24"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.13181\/mji.v24i3.1044"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.13181\/mji.oa.203849"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3126\/nepjoph.v3i1.4269"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-213547"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.5935\/0034-7280.20180115"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.22336\/rjo.2019.25"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-004-0083-x"},{"key":"B16","unstructured":"Gurnani B, Kaur K.   Therapeutic Keratoplasty. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2025"}],"container-title":["World Journal of Transplantation"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2220-3230\/full\/v15\/i4\/106380.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2220-3230\/full\/v15\/i4\/106380.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T06:23:22Z","timestamp":1763447002000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2220-3230\/full\/v15\/i4\/106380.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":16,"journal-issue":{"issue":"4"},"alternative-id":["106380"],"URL":"https:\/\/doi.org\/10.5500\/wjt.v15.i4.106380","relation":{},"ISSN":["2220-3230"],"issn-type":[{"type":"print","value":"2220-3230"}],"subject":[],"published":{"date-parts":[[2025,12,18]]}}}