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The symptoms of CF mainly represent the tissue tropism of the virus rather than the immunopathogenesis triggered by the host's immune system. The main mechanisms associated with arthralgia have been linked to an increase in T helper type 17 cells and a consequent increase in receptor activator of nuclear factor kappa-\u0392 ligand and bone resorption. This review suggests that persistent arthralgia results from the presence of viral antigens post-infection and the constant activation of signaling lymphocytic activation molecule family member 7 in synovial macrophages, leading to local infiltration of CD4+ T cells, which sustains the inflammatory process in the joints through the secretion of pro-inflammatory cytokines. The term \"long chikungunya\" was used in this review to refer to persistent arthralgia since, due to its manifestation over long periods after the end of the viral infection, this clinical condition seems to be characterized more as a sequel than as a symptom, given that there is no active infection involved.<\/jats:p>","DOI":"10.5501\/wjv.v13.i2.89985","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T05:39:23Z","timestamp":1719207563000},"source":"Crossref","is-referenced-by-count":7,"title":["Long chikungunya? 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