{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:49:59Z","timestamp":1793137799241,"version":"4.5.0"},"reference-count":95,"publisher":"Baishideng Publishing Group Inc.","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Virol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Invasive fungal infections, particularly candidemia, pose significant clinical challenges globally. Understanding local epidemiology, species distribution, and antifungal susceptibility patterns is crucial for effective management despite regional variations.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To investigate the epidemiology, species distribution, antifungal susceptibility patterns, and associated risk factors of candidemia among patients in Bahrain from 2021 to 2023.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>This retrospective study analyzed demographic data, Candida  species distribution, antifungal susceptibility profiles, and risk factors among candidemia patients treated at a tertiary care hospital in Bahrain over three years. Data was collected from medical records and analyzed using descriptive statistics.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>A total of 430 candidemia cases were identified. The mean age of patients was 65.7 years, with a mortality rate of 85.5%. Candida albicans  (C. albicans ) was the most common species, followed by Candida parapsilosis , Candida tropicalis (C. tropicalis) , and emerging multidrug-resistant Candida auris  (C. auris ). Antifungal susceptibility varied across species, with declining susceptibility to azoles observed, particularly among C. albicans  and C. tropicalis . Major risk factors included central venous catheters, broad-spectrum antibiotics, and surgical procedures.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>This study highlights the substantial burden of candidemia among older adults in Bahrain, characterized by diverse Candida  species. It also concerns levels of antifungal resistance, notably in C. auris . The findings underscore the importance of local epidemiological surveillance and tailored treatment strategies to improve outcomes and mitigate the spread of multidrug-resistant Candida  species. Future research should focus on molecular resistance mechanisms and optimizing therapeutic approaches to address this growing public health concern.<\/jats:p>","DOI":"10.5501\/wjv.v13.i4.98839","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T01:19:28Z","timestamp":1729214368000},"source":"Crossref","is-referenced-by-count":4,"title":["Candidemia chronicles: Retrospective analysis of candidemia epidemiology, species distribution, and antifungal susceptibility patterns in Bahrain"],"prefix":"10.5501","volume":"13","author":[{"given":"Nermin Kamal","family":"Saeed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safiya","family":"Almusawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al-Beltagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2019.1612661"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/jof7020079"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2021.03.007"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2017.04.010"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06240-x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/jof8020116"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-2766-1"},{"key":"B9","unstructured":"Badiee P, Alborzi A. 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