{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T03:40:04Z","timestamp":1750650004065,"version":"3.41.0"},"reference-count":25,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Virol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Treatment response to direct-acting antivirals (DAAs) is a challenging issue and the identification of non-responders patients is very important.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To evaluate the relation between baseline serum levels of hyaluronic acid (HA) and type III procollagen N-peptide (PIIINP) with direct-acting antivirals treatment failure in Egyptian patients with chronic hepatitis C.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>Hepatitis C patients (responders and non-responders to sofosbuvir\/daclatasvir) were tested for HA and PIIINP using sensitive chemiluminescent immunoassay.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>There were distinctly higher PIIINP (P  = 0.0003) and HA (P  &lt; 0.0001) levels in non-responders than responders patients with a good ability for distinguishing non-responders from patients with sustained virological response (area under the curve = 0.766 for HA and 0.684 for PIIINP). Logistic regression analysis revealed that the HA \u00d7 PIIINP is the model with the highest predictive ability (area under the curve = 0.809). Diagnostic performances were superior to each marker alone with good sensitivity (74.7%), specificity (74%), positive predictive (68.3%), negative predictive values (79.6%) and accuracy (74.3%). The multiplication of HA \u00d7 PIIINP is correlated significantly (P  &lt; 0.05) with elevated liver enzymes (r  = 0.212), decreased albumin (r  = -0.26), elevated aspartate aminotransferase-platelet ratio index (r  = 0.223) and elevated fibrosis-4 score (r  = 0.216) scores.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>These findings suggested the remarkable role of fibrogensis markers HA and PIIINP in the prediction of hepatitis C virus DAAs treatment response. Multiplying HA with PIIINP values increase the sensitivity to detect treatment success and thus may aim to improve treatment duration and the disease control.<\/jats:p>","DOI":"10.5501\/wjv.v14.i2.106479","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T03:02:34Z","timestamp":1750647754000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of hyaluronic acid and type III procollagen peptide as predictors for treatment response to direct-acting antivirals"],"prefix":"10.5501","volume":"14","author":[{"given":"Mohamed A","family":"Abdelrazek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed I","family":"Elghwab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf A","family":"Tabll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsherbiny H","family":"Elsayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"El Behery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/v15112199"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1041201"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2023.105742"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.10.024"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0282013"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01196-0"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32347"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2021.109293"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2021.2001045"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2023.104937"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(01)00091-5"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12668"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.08.018"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21178"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50346"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2147\/HMER.S292251"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.551500"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001612"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2147\/HMER.S62014"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14428"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.031"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14482"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2020.11.018"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2006.00730.x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-22819-4"}],"container-title":["World Journal of Virology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2220-3249\/full\/v14\/i2\/106479.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2220-3249\/full\/v14\/i2\/106479.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T03:03:12Z","timestamp":1750647792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2220-3249\/full\/v14\/i2\/106479.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":25,"journal-issue":{"issue":"2"},"alternative-id":["106479"],"URL":"https:\/\/doi.org\/10.5501\/wjv.v14.i2.106479","relation":{},"ISSN":["2220-3249"],"issn-type":[{"value":"2220-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,25]]}}}