{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:44:12Z","timestamp":1783385052708,"version":"3.54.6"},"reference-count":25,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Virol"],"abstract":"<jats:p>According to the World Health Organization, an estimated 58 million people worldwide are chronically infected with hepatitis C virus (HCV), yet only about 20% have been formally diagnosed. Traditional laboratory\u2013based antibody and RNA assays require infrastructure and trained personnel, limiting their uptake in resource-limited and hard-to-reach settings. The OraQuick HCV self-test (HCVST) is the first World Health Organization-prequalified HCVST, which delivers results in 20-40 min via  an easy-to-use gum-swab format. Field evaluations report a sensitivity of about 97%\u201398% and a specificity of about 99%\u2013100% that are comparable with those of blood-based lateral-flow assays (e.g. , Alere Truline, SD Bioline). Usability studies demonstrated an acceptability rate of over 90% and a correct self-test completion rate of over 85% in key populations. HCVST with the OraQuick HCVST kit provides a practical, evidence-based approach to closing diagnostic gaps, particularly among underserved or stigmatized populations. To maximize the public health impact, programs should integrate self-testing into national screening algorithms, ensure linkage to RNA confirmation and treatment, and consider economic and operational contexts.<\/jats:p>","DOI":"10.5501\/wjv.v14.i3.109614","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T01:45:58Z","timestamp":1758678358000},"source":"Crossref","is-referenced-by-count":2,"title":["OraQuick hepatitis C virus self-test: A new frontier in hepatitis C screening"],"prefix":"10.5501","volume":"14","author":[{"given":"Muneeb","family":"Saifullah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mavra","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ashhad","family":"Usman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qasim","family":"Mehmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas M","family":"Mehdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,9,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2019.01.001"},{"key":"B2","unstructured":"World Health Organization.   Hepatitis C. [cited 9 July 2025]. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-c"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.07.012"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4103\/0973-6247.126683"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/cld.760"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiad463"},{"key":"B7","unstructured":"Basit H, Tyagi I, Koirala J.   Hepatitis C. 2023 Mar 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2025"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2020.00095"},{"key":"B9","unstructured":"Centers for Disease Control and Prevention.   CDC Clinical Overview of Hepatitis C. [cited 9 July 2025]. Available from: https:\/\/www.cdc.gov\/hepatitis-c\/hcp\/clinical-overview\/index.html"},{"key":"B10","doi-asserted-by":"crossref","unstructured":"Joshi SN. Hepatitis C screening. Ochsner J 2014; 664-668","DOI":"10.1001\/jama.2013.281899"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/s1286-4579(02)01650-7"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-024-00443-2"},{"key":"B13","unstructured":"World Health Organization.   Global Health Sector Strategies on, Respectively, HIV, Viral Hepatitis and Sexually Transmitted Infections for the Period 2022-2030. [cited 9 July 2025]. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240053779"},{"key":"B14","unstructured":"World Health Organization.   Global Hepatitis Report 2017. [cited 9 July 2025]. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789241565455"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0210556"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2013.33.3.184"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0484"},{"key":"B18","unstructured":"World Health Organization.   WHO Prequalifies the First Self-Test for Hepatitis C Virus. [cited 9 July 2025]. Available from: https:\/\/www.who.int\/news\/item\/10-07-2024-who-prequalifies-the-first-self-test-for-hepatitis-c-virus"},{"key":"B19","unstructured":"OraSure Technologies Inc.   OraQuick Hepatitis C Test. [cited 9 July 2025]. Available from: https:\/\/orasure.com\/products\/OraQuick-HCV.html"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11020377"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13876"},{"key":"B22","unstructured":"OraQuick\u00ae Hepatitis C Self-Test.   Simple and reliable HCV Self testing. [cited 9 July 2025]. Available from: https:\/\/global.oraquick.com\/hcv"},{"key":"B23","unstructured":"Centers for Disease Control and Prevention.   Clinical Screening and Diagnosis for Hepatitis C. [cited 9 July 2025]. Available online: https:\/\/www.cdc.gov\/hepatitis-c\/hcp\/diagnosis-testing\/index.html"},{"key":"B24","unstructured":"National Institute for Health and Care Excellence.   The OraQuick HCV Point-of-Care Test for Rapid Detection of Hepatitis C Virus Antibodies. [cited 9 July 2025]. Available from: https:\/\/www.nice.org.uk\/advice\/mib24\/resources\/the-oraquick-hcv-pointofcare-test-for-rapid-detection-of-hepatitisc-virus-antibodies-63499045128901"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0001667"}],"container-title":["World Journal of Virology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/2220-3249\/full\/v14\/i3\/109614.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/2220-3249\/full\/v14\/i3\/109614.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T01:46:32Z","timestamp":1758678392000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/2220-3249\/full\/v14\/i3\/109614.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,25]]},"references-count":25,"journal-issue":{"issue":"3"},"alternative-id":["109614"],"URL":"https:\/\/doi.org\/10.5501\/wjv.v14.i3.109614","relation":{},"ISSN":["2220-3249"],"issn-type":[{"value":"2220-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,25]]}}}