{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:26:59Z","timestamp":1760401619506,"version":"build-2065373602"},"reference-count":0,"publisher":"Egyptian Association of Immunologists","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EJI"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p>Type 2 diabetes (T2DM) is the most prevalent form of diabetes, and frequently associated with diabetic nephropathy, a leading contributor to chronic kidney disease (CKD). The presence of microalbuminuria serves as an early marker for diabetic kidney disease (DKD). Emerging evidence suggested that alterations in microRNA (miRNA) 30e-5p expression may be linked to T2DM progression, positioning it as a potential biomarker. This study investigated the clinical relevance of miRNA 30e-5p dysregulation by assessing its expression levels in T2DM patients with and without DKD. A total of 50 participants, including 25 T2DM patients with DKD and 25 T2DM patients without DKD, were examined. Serum miRNA 30e-5p levels were quantified using real-time polymerase chain reaction. Findings revealed a significant reduction in miRNA 30e-5p expression among patients with DKD compared to those without DKD (0.25 \u00b1 0.26 vs. 0.89 \u00b1 0.13, p &lt; 0.001). In conclusion, miRNA 30e-5p dysregulation appears to contribute to DKD development in Egyptian T2DM patients, suggesting its potential as a prognostic biomarker.<\/jats:p>","DOI":"10.55133\/eji.320401","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:33:04Z","timestamp":1760347984000},"page":"01-07","source":"Crossref","is-referenced-by-count":0,"title":["Expression of serum microRNA 30e-5p in type 2 diabetic patients with diabetic kidney disease"],"prefix":"10.55133","volume":"32","author":[{"name":"Department of Clinical & Chemical Pathology, Faculty of Medicine, Beni-Suef University, , Beni-Suef, Egypt.","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shymaa","family":"Khalil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33636","published-online":{"date-parts":[[2025,10,1]]},"container-title":["The Egyptian journal of Immunology"],"original-title":[],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:33:06Z","timestamp":1760347986000},"score":1,"resource":{"primary":{"URL":"https:\/\/ejimmunology.org\/vol-32-4-2025-01"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,10,1]]},"published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.55133\/eji.320401","relation":{},"ISSN":["1110-4902","2090-2506"],"issn-type":[{"value":"1110-4902","type":"print"},{"value":"2090-2506","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]}}}