{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:30:37Z","timestamp":1760401837509,"version":"build-2065373602"},"reference-count":0,"publisher":"Egyptian Association of Immunologists","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EJI"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p>Neonatal sepsis is an important cause of morbidity and mortality. High mobility group box1 protein (HMGB1) is a cytokine that can mediate inflammation. The aim of this research was to investigate the role of HMGB1 in diagnosis and prognosis of late onset neonatal sepsis. This observational case-control study included 80 newborn infants \u226537 weeks of gestation. Newborn infants were assigned into two groups: the late-onset neonatal septic group included 40 infant cases, and the control group included 40 newborn infants. Clinical sepsis score, hematological sepsis score and serum level of C-reactive protein were assessed and blood culture performed. HMGB1 was measured by an enzyme-linked immunosorbent assay. There was a significant increase of HMGB1 in the late-onset neonatal septic group than the control group (p&lt; 0. 001). The best cut off point of HMGB 1 to discriminate against the late-onset sepsis cases from the control newborn infants was &gt; 68 ng\/ml with a sensitivity of 97.5%, specificity of 95%, positive predictive value of 95.1% and negative predictive value of 97.4% with total accuracy of 0.99%. The values of HMGB1 were not affected by gestational age, birth weight, postnatal age or gender. There were no significant differences in mean values between survival and non-survival cases. The best cut off value to predict mortality in the late onset sepsis group was &gt;167.8 ng\/ml with a sensitivity of 60% and specificity of 54.29%. In conclusion, this study suggested that HMGB1 is a promising marker for diagnosis of late onset neonatal sepsis in full term infants, on the contrary HMGB1 could not predict mortality in neonatal septic patients.<\/jats:p>","DOI":"10.55133\/eji.320413","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T10:42:26Z","timestamp":1760352146000},"page":"110-115","source":"Crossref","is-referenced-by-count":0,"title":["Role of high-mobility group box 1 in late onset neonatal sepsis"],"prefix":"10.55133","volume":"32","author":[{"name":"Department of Pediatrics, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan","family":"Zeiada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"33636","published-online":{"date-parts":[[2025,10,1]]},"container-title":["The Egyptian journal of Immunology"],"original-title":[],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T10:42:27Z","timestamp":1760352147000},"score":1,"resource":{"primary":{"URL":"https:\/\/ejimmunology.org\/vol-32-4-2025-13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,10,1]]},"published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.55133\/eji.320413","relation":{},"ISSN":["1110-4902","2090-2506"],"issn-type":[{"value":"1110-4902","type":"print"},{"value":"2090-2506","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]}}}