{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:27:20Z","timestamp":1786534040393,"version":"build-2736575974"},"reference-count":34,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nephrol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Diabetic nephropathy (DN) is a major complication that arises from diabetes. Curcumin, a bioactive compound with antioxidant properties, has been shown to modulate multiple cellular pathways and thereby mitigate tissue damage.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To explore the influence of curcumin on high glucose-triggered apoptosis in renal tubular epithelial cells.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>Sprague-Dawley rats were divided into control, diabetic, and curcumin treatment groups (n  = 10\/group). Renal function markers (neutrophil gelatinase-associated lipocalin, KIM-1, and urinary albumin) were assessed, and renal tissues were analyzed using histopathology, TUNEL assays, and immunohistochemistry. Renal tubular epithelial cells were cultured under normal (5.5 mmol\/L) or high glucose (30 mmol\/L) conditions, with or without curcumin. Apoptosis, reactive oxygen species (ROS) levels, and Nrf2\/heme oxygenase-1 (HO-1) signaling pathway markers were evaluated using flow cytometry, quantitative polymerase chain reaction, and immunohistochemistry.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>Curcumin improved renal function markers and reduced renal tubular apoptosis in diabetic rats. In vitro , it suppressed high glucose-induced apoptosis and ROS production, while activating the Nrf2\/HO-1 antioxidant pathway (upregulated Nrf2 and HO-1 expression, and downregulated Keap1) and modulating the Bcl-2\/Bax apoptotic balance (downregulated Bax and upregulated Bcl-2), demonstrating sequential protection against oxidative stress followed by apoptosis inhibition.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>Curcumin protects against high glucose\u2013induced renal tubular epithelial apoptosis by enhancing Nrf2\/HO-1 signaling to reduce oxidative stress and apoptosis, indicating its therapeutic potential for DN.<\/jats:p>","DOI":"10.5527\/wjn.119984","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:37:42Z","timestamp":1780414662000},"source":"Crossref","is-referenced-by-count":0,"title":["Curcumin attenuates high glucose-induced apoptosis in renal tubular epithelial cells by enhancing the 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