{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T02:52:33Z","timestamp":1781491953422,"version":"3.54.1"},"reference-count":65,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Nephrol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Testicular ischemia\/reperfusion (I\/R) injury may affect distant organs. During I\/R, metabolites formed in the affected organ are released into the circulation; thus, non-ischemic organs, such as the kidneys and lungs, become involved in the inflammatory process, even if they are not primarily affected. Damage from testicular torsion\/detorsion (T\/D) models has been shown to affect kidneys. There is a need to examine the nephroprotective effect of boric acid (BA), which is known to have antioxidant effects, on kidney damage.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To investigate kidney damage in a rat testicular T\/D model and the effectiveness of BA on this distant organ damage.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>Twenty-four male Wistar albino rats were divided into four groups (n  = 6 each)-control (group C), BA (group BA), T\/D (group I\/R), BA-T\/D (group BA-I\/R). In all groups, the scrotum was cut longitudinally, and the testis was dissected. No medication was administered to groups C and group I\/R. Groups BA and group BA-I\/R were administered 50 mg\/kg BA intraperitoneally half an hour before the surgical procedure. The testicular T\/D model was applied to groups I\/R and group BA-I\/R. The malondialdehyde (MDA) level, catalase, glutathione S-transferase, and paraoxonase-1 (PON-1) enzyme activities were measured in kidney tissue. Additionally, sections were taken and evaluated for histopathological examination.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>An increase in MDA levels and a decrease in PON-1 activity were detected in the I\/R group compared to the control group (P  = 0.001, P  = 0.002, respectively). MDA levels were found to be significantly lower in the BA-I\/R group than in the I\/R group (P  = 0.041). PON-1 enzyme activity was found to be significantly higher in the BA-I\/R group than in the I\/R group (P  = 0.048). The light microscopy examination showed an increase in glomerular vacuolization, tubular dilatation, vascular vacuolization and hypertrophy (VVH), and tubular cell degeneration and necrosis damage scores in the I\/R group compared to the control group (P  = 0.003, P  = 0.005, P  = 0.008, and P  &lt; 0.001, respectively). In the I\/R group treated with BA, tubular dilatation and VVH scores decreased compared to the I\/R group (P  = 0.037 and P  = 0.048, respectively).<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>These findings show that the testicular T\/D model in rats causes kidney damage, and BA administration reduces this damage in the kidneys.<\/jats:p>","DOI":"10.5527\/wjn.v15.i2.116474","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T02:09:13Z","timestamp":1781489353000},"source":"Crossref","is-referenced-by-count":0,"title":["Protective effect of boric acid on kidney tissue and oxidative stress after testicular torsion\/detorsion in male rats"],"prefix":"10.5527","volume":"15","author":[{"given":"U\u011fur M","family":"Adam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metin","family":"Alkan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eaban C","family":"Sezen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Kavut\u00e7u","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2017.11.034"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00300075"},{"key":"B3","unstructured":"Sharp VJ, Kieran K, Arlen AM. 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