{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T21:04:17Z","timestamp":1786395857338,"version":"build-2736575974"},"reference-count":30,"publisher":"Japan Atherosclerosis Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Atheroscler Thromb","JAT"],"published-print":{"date-parts":[[2015]]},"DOI":"10.5551\/jat.25718","type":"journal-article","created":{"date-parts":[[2014,9,7]],"date-time":"2014-09-07T19:02:13Z","timestamp":1410116533000},"page":"136-143","source":"Crossref","is-referenced-by-count":28,"title":["Association between the Circulating Total Osteocalcin Level and the Development of Cardiovascular Disease in Middle-aged Men: A Mean 8.7-year Longitudinal Follow-up Study"],"prefix":"10.5551","volume":"22","author":[{"given":"You-Cheol","family":"Hwang","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Kang","sequence":"additional","affiliation":[{"name":"Center for Health Promotion, Samsung Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Jin","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Kyung","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Jeung","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Yeon","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon-Kyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3489","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Kado DM, Browner WS, Blackwell T, Gore R, Cummings SR: Rate of bone loss is associated with mortality in older women: a prospective study. J Bone Miner Res, 2000; 15: 1974-1980","DOI":"10.1359\/jbmr.2000.15.10.1974"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Trivedi DP, Khaw KT: Bone mineral density at the hip predicts mortality in elderly men. Osteoporos Int, 2001; 12: 259-265","DOI":"10.1007\/s001980170114"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Kiel DP, Kauppila LI, Cupples LA, Hannan MT, O\u2019Donnell CJ, Wilson PW: Bone loss and the progression of abdominal aortic calcification over a 25 year period: the Framingham Heart Study. Calcif Tissue Int, 2001; 68: 271-276","DOI":"10.1007\/BF02390833"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Hyder JA, Allison MA, Wong N, Papa A, Lang TF, Sirlin C, Gapstur SM, Ouyang P, Carr JJ, Criqui MH: Association of coronary artery and aortic calcium with lumbar bone density: the MESA Abdominal Aortic Calcium Study. Am J Epidemiol, 2009; 169: 186-194","DOI":"10.1093\/aje\/kwn303"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Frost ML, Grella R, Millasseau SC, Jiang BY, Hampson G, Fogelman I, Chowienczyk PJ: Relationship of calcification of atherosclerotic plaque and arterial stiffness to bone mineral density and osteoprotegerin in postmenopausal women referred for osteoporosis screening. Calcif Tissue Int, 2008; 83: 112-120","DOI":"10.1007\/s00223-008-9153-2"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Eastell R, Newman C, Crossman DC: Cardiovascular disease and bone. Arch Biochem Biophys, 2010; 503: 78-83","DOI":"10.1016\/j.abb.2010.06.008"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, Reid IR: Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ, 2010; 341: c3691","DOI":"10.1136\/bmj.c3691"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR: Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women\u2019s Health Initiative limited access dataset and meta-analysis. BMJ, 2011; 342: d2040","DOI":"10.1136\/bmj.d2040"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Elamin MB, Abu Elnour NO, Elamin KB, Fatourechi MM, Alkatib AA, Almandoz JP, Liu H, Lane MA, Mullan RJ, Hazem A, Erwin PJ, Hensrud DD, Murad MH, Montori VM: Vitamin D and cardiovascular outcomes: a systematic review and meta-analysis. J Clin Endocrinol Metab, 2011; 96: 1931-1942","DOI":"10.1210\/jc.2011-0398"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G: Endocrine regulation of energy metabolism by the skeleton. Cell, 2007; 130: 456-469","DOI":"10.1016\/j.cell.2007.05.047"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Ducy P: The role of osteocalcin in the endocrine crosstalk between bone remodelling and energy metabolism. Diabetologia, 2011; 54: 1291-1297","DOI":"10.1007\/s00125-011-2155-z"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Fernandez-Real JM, Izquierdo M, Ortega F, Gorostiaga E, Gomez-Ambrosi J, Moreno-Navarrete JM, Fruhbeck G, Martinez C, Idoate F, Salvador J, Forga L, Ricart W, Ibanez J: The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training. J Clin Endocrinol Metab, 2009; 94: 237-245","DOI":"10.1210\/jc.2008-0270"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Hwang YC, Jeong IK, Ahn KJ, Chung HY: The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjects. Diabetes Metab Res Rev, 2009; 25: 768-772","DOI":"10.1002\/dmrr.1045"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Hwang YC, Jeong IK, Ahn KJ, Chung HY: Circulating osteocalcin level is associated with improved glucose tolerance, insulin secretion and sensitivity independent of the plasma adiponectin level. Osteoporos Int, 2012; 23: 1337-1342","DOI":"10.1007\/s00198-011-1679-x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Saleem U, Mosley TH Jr, Kullo IJ: Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome. Arterioscler Thromb Vasc Biol, 2010; 30: 1474-1478","DOI":"10.1161\/ATVBAHA.110.204859"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S, Sugimoto T: Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endocrinol Metab, 2009; 94: 45-49","DOI":"10.1210\/jc.2008-1455"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Yeap BB, Chubb SA, Flicker L, McCaul KA, Ebeling PR, Hankey GJ, Beilby JP, Norman PE: Associations of total osteocalcin with all-cause and cardiovascular mortality in older men. The Health In Men Study. Osteoporos Int, 2012; 23: 599-606","DOI":"10.1007\/s00198-011-1586-1"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Hwang YC, Jee JH, Oh EY, Choi YH, Lee MS, Kim KW, Lee MK: Metabolic syndrome as a predictor of cardiovascular diseases and type 2 diabetes in Koreans. Int J Cardiol, 2009; 134: 313-321","DOI":"10.1016\/j.ijcard.2008.12.025"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C; American Heart Association; National Heart, Lung, and Blood Institute: Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute\/American Heart Association conference on scientific issues related to definition. Circulation, 2004; 109: 433-438","DOI":"10.1161\/01.CIR.0000111245.75752.C6"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes Care, 2009; 32 Suppl 1: S62-67","DOI":"10.2337\/dc09-S062"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Ngarmukos C, Chailurkit LO, Chanprasertyothin S, Hengprasith B, Sritara P, Ongphiphadhanakul B: A reduced serum level of total osteocalcin in men predicts development of diabetes in a long-term follow-up cohort. Clin Endocrinol, 2012; 77: 42-46","DOI":"10.1111\/j.1365-2265.2011.04215.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Zhang Y, Qi L, Gu W, Yan Q, Dai M, Shi J, Zhai Y, Chen Y, Liu J, Wang W, Ning G, Hong J: Relation of serum osteocalcin level to risk of coronary heart disease in Chinese adults. Am J Cardiol, 2010; 106: 1461-1465","DOI":"10.1016\/j.amjcard.2010.07.013"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Jung CH, Lee WJ, Hwang JY, Lee MJ, Seol SM, Kim YM, Lee YL, Park JY: The preventive effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of phosphatidylinositol 3-kinase\/Akt signaling pathway. Metabolism, 2013; 62: 1250-1257","DOI":"10.1016\/j.metabol.2013.03.005"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Yamashita T, Okano K, Tsuruta Y, Akiba T, Nitta K: Serum osteocalcin levels are useful as a predictor of cardiovascular events in maintenance hemodialysis patients. Int Urol Nephrol, 2013; 45: 207-214","DOI":"10.1007\/s11255-012-0156-6"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Szulc P, Arlot M, Chapuy MC, Duboeuf F, Meunier PJ, Delmas PD: Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women. J Bone Miner Res, 1994; 9: 1591-1595","DOI":"10.1002\/jbmr.5650091012"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Szulc P, Chapuy MC, Meunier PJ, Delmas PD: Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest, 1993; 91: 1769-1774","DOI":"10.1172\/JCI116387"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Tanko LB, Christiansen C, Cox DA, Geiger MJ, McNabb MA, Cummings SR: Relationship between osteoporosis and cardiovascular disease in postmenopausal women. J Bone Miner Res, 2005; 20: 1912-1920","DOI":"10.1359\/JBMR.050711"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Gossl M, Modder UI, Atkinson EJ, Lerman A, Khosla S: Osteocalcin expression by circulating endothelial progenitor cells in patients with coronary atherosclerosis. J Am Coll Cardiol, 2008; 52: 1314-1325","DOI":"10.1016\/j.jacc.2008.07.019"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Okura T, Kurata M, Enomoto D, Jotoku M, Nagao T, Desilva VR, Irita J, Miyoshi K, Higaki J: Undercarboxylated osteocalcin is a biomarker of carotid calcification in patients with essential hypertension. Kidney Blood Press Res, 2010; 33: 66-71","DOI":"10.1159\/000289575"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Hwang YC, Jee JH, Jeong IK, Ahn KJ, Chung HY, Lee MK: Circulating osteocalcin level is not associated with incident type 2 diabetes in middle-aged male subjects: mean 8.4-year retrospective follow-up study. Diabetes Care, 2012; 35: 1919-1924","DOI":"10.2337\/dc11-2471"}],"container-title":["Journal of Atherosclerosis and Thrombosis"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T15:11:16Z","timestamp":1565795476000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/22\/2\/22_25718\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.5551\/jat.25718","relation":{},"ISSN":["1340-3478","1880-3873"],"issn-type":[{"value":"1340-3478","type":"print"},{"value":"1880-3873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}