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J Clin Invest, 2010; 120: 254-265","DOI":"10.1172\/JCI40295"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Paravicini TM, Touyz RM: Redox signaling in hypertension. Cardiovasc Res, 2006; 71: 247-258","DOI":"10.1016\/j.cardiores.2006.05.001"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Vogel V, Bokemeyer D, Heller J, Kramer HJ: Cardiac hypertrophy in the Prague-hypertensive rat is associated with enhanced JNK2 but not ERK tissue activity. Kidney Blood Press Res, 2001; 24: 52-56","DOI":"10.1159\/000054206"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Valen G: Innate immunity and remodelling. 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