{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T20:42:48Z","timestamp":1784234568269,"version":"3.55.0"},"reference-count":40,"publisher":"Japan Atherosclerosis Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Atheroscler Thromb","JAT"],"published-print":{"date-parts":[[2016]]},"DOI":"10.5551\/jat.32300","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T22:05:58Z","timestamp":1449007558000},"page":"557-566","source":"Crossref","is-referenced-by-count":25,"title":["Myocardial Production of Plasminogen Activator Inhibitor-1 is Associated with Coronary Endothelial and Ventricular Dysfunction after Acute Myocardial Infarction"],"prefix":"10.5551","volume":"23","author":[{"given":"Takuya","family":"Shimizu","sequence":"first","affiliation":[{"name":"University of Yamanashi, Department of Internal Medicine II"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Uematsu","sequence":"additional","affiliation":[{"name":"University of Yamanashi, Department of Internal Medicine II"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yoshizaki","sequence":"additional","affiliation":[{"name":"University of Yamanashi, Department of Internal Medicine II"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ei","family":"Obata","sequence":"additional","affiliation":[{"name":"University of Yamanashi, Department of Internal Medicine II"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"University of Yamanashi, Department of Internal Medicine II"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Fujioka","sequence":"additional","affiliation":[{"name":"University of Yamanashi, Department of Internal Medicine II"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"University of Yamanashi, Department of Internal Medicine II"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"University of Yamanashi, Department of Internal Medicine II"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Kugiyama","sequence":"additional","affiliation":[{"name":"University of Yamanashi, Department of Internal Medicine II"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3489","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Hoffmeister HM, Jur M, Ruf-Lehmann M, Helber U, Heller W, Seipel L: Endothelial tissue-type plasminogen activator release in coronary heart disease: Transient reduction in endothelial fibrinolytic reserve in patients with unstable angina pectoris or acute myocardial infarction. J Am Coll Cardiol, 1998; 31: 547-551","DOI":"10.1016\/S0735-1097(97)00531-7"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Soejima H, Ogawa H, Suefuji H, Kaikita K, Takazoe K, Miyamoto S, Kajiwara I, Shimomura H, Sakamoto T, Yoshimura M, Nakamura S: Comparison of effects of losartan versus enalapril on fibrinolysis and coagulation in patients with acute myocardial infarction. Am J Cardiol, 2001; 87: 1408-1411","DOI":"10.1016\/S0002-9149(01)01565-X"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Hirashima O, Ogawa H, Oshima S, Sakamoto T, Honda Y, Sakata S, Masuda T, Miyao Y, Yasue H: Serial changes of plasma plasminogen activator inhibitor activity in acute myocardial infarction: difference between thrombolytic therapy and direct coronary angioplasty. Am Heart J, 1995; 130: 933-939","DOI":"10.1016\/0002-8703(95)90191-4"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Lucore CL, Sobel BE: Interactions of tissue-type plasminogen activator with plasma inhibitors and their pharmacologic implications. Circulation, 1988; 77: 660-669","DOI":"10.1161\/01.CIR.77.3.660"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Sprengers ED, Kluft C: Plasminogen activator inhibitors. Blood, 1987; 69: 381-387","DOI":"10.1182\/blood.V69.2.381.381"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Nordenhem A, Wiman B: Tissue plasminogen activator (tPA) antigen in plasma: correlation with different tPA\/inhibitor complexes. Scand J Clin Lab Invest, 1998; 58: 475-483","DOI":"10.1080\/00365519850186274"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Kohler HP, Grant PJ: Plasminogen-activator inhibitor type 1 and coronary artery disease. N Engl J Med, 2000; 342: 1792-1801","DOI":"10.1056\/NEJM200006153422406"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Ploplis VA: Effects of altered plasminogen activator inhibitor-1 expression on cardiovascular disease. Curr Drug Targets, 2011; 12: 1782-1789","DOI":"10.2174\/138945011797635803"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Hamsten A, de Faire U, Walldius G, Dahl\u00e9n G, Szamosi A, Landou C, Blomb\u00e4ck M, Wiman B: Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction. Lancet, 1987; 2: 3-9","DOI":"10.1016\/S0140-6736(87)93050-9"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Sinkovic A, Pogacar V: Risk stratification in patients with unstable angina and\/or non-ST-elevation myocardial infarction by Troponin T and plasminogen-activatorinhibitor-1 (PAI-1). Thromb Res, 2004; 114: 251-257","DOI":"10.1016\/j.thromres.2004.06.040"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Soeki T, Tamura Y, Shinohara H, Sakabe K, Onose Y, Fukuda N: Plasma concentrations of fibrinolytic factors in the subacute phase of myocardial infarction predict recurrent myocardial infarction or sudden cardiac death. Int J Cardiol, 2002; 85: 277-283","DOI":"10.1016\/S0167-5273(02)00186-9"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Diebold I, Kraicun D, Bonello S, G\u00f6rlach A: The \u2018PAI-1 paradox\u2019 in vascular remodeling. Thromb Haemost, 2008; 100: 984-991","DOI":"10.1160\/TH08-08-0524"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Takeshita K, Hayashi M, Iino S, Kondo T, Inden Y, Iwase M, Kojima T, Hirai M, Ito M, Loskutoff DJ, Saito H, Murohara T, Yamamoto K: Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction. Am J Pathol, 2004; 164: 449-456","DOI":"10.1016\/S0002-9440(10)63135-5"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Zaman AK, French CJ, Schneider DJ, Sobel BE: A profibrotic effect of plasminogen activator inhibitor type-1 (PAI-1) in the heart. Exp Biol Med (Maywood), 2009; 234: 246-254","DOI":"10.3181\/0811-RM-321"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Huber K, Christ G, Wojta J, Gulba D: Plasminogen activator inhibitor type-1 in cardiovascular disease. Status report 2001. Thromb Res, 2001; 103 Suppl 1: S7-19","DOI":"10.1016\/S0049-3848(01)00293-6"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Chua S, Wang HL, Lin YC, Wu CH, Tsai TH, Chang LT, Kao YH, Yen CH, Yip HK, Sun CK: Enhanced expression of plasminogen activator inhibitor may prevent cardiac rupture in female and castrated mice after myocardial infarction. Gend Med, 2011; 8: 239-251","DOI":"10.1016\/j.genm.2011.05.006"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Shindo J, Ishibashi T, Kijima M, Nakazato K, Nagata K, Yokoyama K, Hirosaka A, Sato E, Kunii H, Yamaguchi N, Watanabe N, Saito T, Maehara K, Maruyama Y: Increased plasminogen activator inhibitor-1 and apolipoprotein (a) in coronary atherectomy specimens in acute coronary syndromes. Coron Artery Dis, 2001; 12: 573-579","DOI":"10.1097\/00019501-200111000-00008"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Eren M, Painter CA, Atkinson JB, Declerck PJ, Vaughan DE: Age-dependent spontaneous coronary arterial thrombosis in transgenic mice that express a stable form of human plasminogen activator inhibitor-1. Circulation, 2002; 106: 491-496","DOI":"10.1161\/01.CIR.0000023186.60090.FB"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Obata JE, Nakamura T, Kitta Y, Kodama Y, Sano K, Kawabata K, Saitoh Y, Fujioka D, Kobayashi T, Yano T, Watanabe Y, Watanabe K, Kugiyama K: Treatment of acute myocardial infarction with sirolimus-eluting stents results in chronic endothelial dysfunction in the infarct-related coronary artery. Circ Cardiovasc Interv, 2009; 2: 384-391","DOI":"10.1161\/CIRCINTERVENTIONS.108.821371"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Mende A, Takano H, Kodama Y, Nakamura T, Umetani K, Fujioka D, Saito Y, Kobayashi T, Kawabata K, Obata JE, Kitta Y, Kugiyama K: Relation between transcardiac gradient of VEGF and coronary flow response in humans. Int J Cardiol, 2007; 119: 156-162","DOI":"10.1016\/j.ijcard.2006.07.112"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Yasue H, Yoshimura M, Sumida H, Kikuta K, Kugiyama K, Jougasaki M, Ogawa H, Okumura K, Mukoyama M, Nakao K: Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure. Circulation, 1994; 90: 195-203","DOI":"10.1161\/01.CIR.90.1.195"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Braunwald E, Antman EM, Beasley JW, Califf RM, Cheitlin MD, Hochman JS, Jones RH, Kereiakes D, Kupersmith J, Levin TN, Pepine CJ, Schaeffer JW, Smith EE 3rd, Steward DE, Theroux P, Gibbons RJ, Alpert JS, Eagle KA, Faxon DP, Fuster V, Gardner TJ, Gregoratos G, Russell RO, Smith SC Jr: ACC\/AHA guidelines for the management of patients with unstable angina and nonST-segment elevation myocardial infarction: executive summary and recommendations. A report of the American College of Cardiology\/American Heart Association task force on practice guidelines (committee on the management of patients with unstable angina). Circulation, 2000; 102: 1193-1209","DOI":"10.1161\/01.CIR.102.10.1193"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Yamamuro A, Akasaka T, Tamita K, Yamabe K, Katayama M, Takagi T, Morioka S: Coronary flow velocity pattern immediately after percutaneous coronary intervention as a predictor of complications and in-hospital survival after acute myocardial infarction. Circulation, 2002; 106: 3051-3056","DOI":"10.1161\/01.CIR.0000043022.44032.77"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Garot P, Pascal O, Simon M, Monin JL, Teiger E, Garot J, Gueret P, Dubois-Rande JL: Impact of microvascular integrity and local viability on left ventricular remodeling after reperfused acute myocardial infarction. Heart, 2003; 89: 393-397","DOI":"10.1136\/heart.89.4.393"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Ueda Y, Ohtani T, Shimizu M, Mizote I, Ohyabu J, Hirayama A, Kodama K: Color of culprit lesion at 6 months after plain old balloon angioplasty versus stenting in patients with acute myocardial infarction. Am Heart J, 2004; 148: 842-846","DOI":"10.1016\/j.ahj.2004.05.034"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Willerson JT, Eidt JF, McNatt J, Yao SK, Golino P, Anderson HV, Buja LM: Role of thromboxane and serotonin as mediators in the development of spontaneous alterations in coronary blood flow and neointimal proliferation in canine models with chronic coronary artery stenoses and endothelial injury. J Am Coll Cardiol, 1991; 17(6 Suppl B): 101B-110B","DOI":"10.1016\/0735-1097(91)90945-6"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Barrab\u00e9s JA, Inserte J, Agull\u00f3 L, Alonso A, Mirabet M, Garcia-Dorado D: Microvascular thrombosis: an exciting but elusive therapeutic target in reperfused acute myocardial infarction. Cardiovasc Hematol Disord Drug Targets, 2010; 10: 273-283","DOI":"10.2174\/187152910793743797"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Lough J, Moore S: Endothelial injury induced by thrombin or thrombi. Lab Invest, 1975; 33: 130-135","DOI":"10.1055\/s-0039-1689124"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Chen SC, Henry DO, Reczek PR, Wong MK: Plasminogen activator inhibitor-1 inhibits prostate tumor growth through endothelial apoptosis. Mol Cancer Ther, 2008; 7: 1227-1236","DOI":"10.1158\/1535-7163.MCT-08-0051"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Stefansson S, Su EJ, Ishigami S, Cale JM, Gao Y, Gorlatova N, Lawrence DA: The contributions of integrin affinity and integrin-cytoskeletal engagement in endothe lial and smooth muscle cell adhesion to vitronectin. J Biol Chem, 2007; 282: 15679-15689","DOI":"10.1074\/jbc.M702125200"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Balsara RD, Ploplis VA: Plasminogen activator inhibitor-1: the double-edged sword in apoptosis. Thromb Hae most, 2008; 100: 1029-1036","DOI":"10.1160\/TH08-07-0427"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Xiang G, Schuster MD, Seki T, Kocher AA, Eshghi S, Boyle A, Itescu S: Down-regulation of plasminogen activator inhibitor 1 expression promotes myocardial neovascularization by bone marrow progenitors. J Exp Med, 2004; 200: 1657-1666","DOI":"10.1084\/jem.20040221"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Chew W, Frangogiannis NG: Fibroblasts in post-infarction inflammation and cardiac repair. Biochim Biophys Acta, 2013; 1833: 945-953","DOI":"10.1016\/j.bbamcr.2012.08.023"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Kluft C, Verheijen JH, Jie AF, Rijken DC, Preston FE, Sue-Ling HM, Jespersen J, Aasen AO: The postoperative fibrinolytic shutdown: a rapidly reverting acute phase pattern for the fast-acting inhibitor of tissue-type plasminogen activator after trauma. Scand J Clin Lab Invest, 1985; 45: 605-610","DOI":"10.3109\/00365518509155267"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Rouleau JL, de Champlain J, Klein M, Bichet D, Moy\u00e9 L, Packer M, Dagenais GR, Sussex B, Arnold JM, Sestier F, Parker JO, McEwan P, Bernstein V, Cuddy E, Lamas G, Gottlieb SS, McCans J, Nadeau C, Delage F, Hamm P, Pfeffer MA: Activation of neurohumoral systems in postinfarction left ventricular dysfunction. J Am Coll Cardiol, 1993; 22: 390-398","DOI":"10.1016\/0735-1097(93)90042-Y"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Vaughan DE: The renin-angiotensin system and fibrinolysis. Am J Cardiol, 1997; 79: 12-16","DOI":"10.1016\/S0002-9149(97)00124-0"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) French CJ, Zaman AK, Sobel BE: The angiotensin receptor blocker, azilsartan medoxomil (TAK-491), suppresses vascular wall expression of plasminogen activator inhibitor type-I protein potentially facilitating the stabilization of atherosclerotic plaques. J Cardiovasc Pharmacol, 2011; 58: 143-148","DOI":"10.1097\/FJC.0b013e31821dcbea"},{"key":"38","unstructured":"38) Bissessor N, White H: Valsartan in the treatment of heart failure or left ventricular dysfunction after myocardial infarction. Vasc Health Risk Manag, 2007; 3: 425-430"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Werner C, Baumh\u00e4kel M, Teo KK, Schmieder R, Mann J, Unger T, Yusuf S, B\u00f6hm M: RAS blockade with ARB and ACE inhibitors: current perspective on rationale and patient selection. Clin Res Cardiol, 2008; 97: 418-431","DOI":"10.1007\/s00392-008-0668-3"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Vaughan DE, Rouleau JL, Ridker PM, Arnold JM, Menapace FJ, Pfeffer MA: Effects of ramipril on plasma fibrinolytic balance in patients with acute anterior myocardial infarction. HEART Study Investigators. Circulation, 1997; 96: 442-447","DOI":"10.1161\/01.CIR.96.2.442"}],"container-title":["Journal of Atherosclerosis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/23\/5\/23_32300\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T00:22:29Z","timestamp":1653697349000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/23\/5\/23_32300\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.5551\/jat.32300","relation":{},"ISSN":["1340-3478","1880-3873"],"issn-type":[{"value":"1340-3478","type":"print"},{"value":"1880-3873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}