{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:15:48Z","timestamp":1780373748697,"version":"3.54.1"},"reference-count":42,"publisher":"Japan Atherosclerosis Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Atheroscler Thromb","JAT"],"published-print":{"date-parts":[[2016]]},"DOI":"10.5551\/jat.34454","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T02:37:04Z","timestamp":1457145424000},"page":"865-877","source":"Crossref","is-referenced-by-count":28,"title":["Beneficial Effects of Exercise-Based Cardiac Rehabilitation on High-Density Lipoprotein-Mediated Cholesterol Efflux Capacity in Patients with Acute Coronary Syndrome"],"prefix":"10.5551","volume":"23","author":[{"given":"Shinji","family":"Koba","sequence":"first","affiliation":[{"name":"The Department of Medicine, Division of Cardiology, Showa University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ayaori","sequence":"additional","affiliation":[{"name":"Division of Anti-aging, Department of Internal Medicine, National Defense Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harumi","family":"Uto-Kondo","sequence":"additional","affiliation":[{"name":"Division of Anti-aging, Department of Internal Medicine, National Defense Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Furuyama","sequence":"additional","affiliation":[{"name":"The Department of Medicine, Division of Cardiology, Showa University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Yokota","sequence":"additional","affiliation":[{"name":"The Department of Medicine, Division of Cardiology, Showa University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiyoshi","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"The Department of Medicine, Division of Cardiology, Showa University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Shoji","sequence":"additional","affiliation":[{"name":"The Department of Medicine, Division of Cardiology, Showa University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Ikewaki","sequence":"additional","affiliation":[{"name":"Division of Anti-aging, Department of Internal Medicine, National Defense Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youichi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"The Department of Medicine, Division of Cardiology, Showa University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3489","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) The Japanese Circulation Society Joint Working Group: Guidelines for Rehabilitation in Patients With Cardiovascular Disease (JCS 2012) - Digest Version -. Circ J, 2014; 78: 2022-2093","DOI":"10.1253\/circj.CJ-66-0094"},{"key":"2","unstructured":"2) Heran BS, Chen JM, Ebrahim S, Moxham T, Oldridge N, Rees K, Thompson DR, Taylor RS: Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev, 2011 Jul 6;(7):CD001800. doi: 10.1002\/ 14651858.CD001800.pub2."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Taylor RS, Brown A, Ebrahim S, Jolliffe J, Noorani H, Rees K, Skidmore B, Stone JA, Thompson DR, Oldridge N: Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. Am J Med, 2004; 116: 682-692","DOI":"10.1016\/j.amjmed.2004.01.009"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Clark AM, Hartling L, Vandermeer B, McAlister FA: Meta-analysis: secondary prevention programs for patients with coronary artery disease. Ann Intern Med, 2005; 143: 659-672","DOI":"10.7326\/0003-4819-143-9-200511010-00010"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, Sugawara A, Totsuka K, Shimano H, Ohashi Y, Yamada N, Sone H: Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA, 2009; 301: 2024-2035","DOI":"10.1001\/jama.2009.681"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Koba S, Tanaka H, Maruyama C, Tada N, Birou S, Teramoto T, Sasaki J: Physical activity in the Japan population: association with blood lipid levels and effects in reducing cardiovascular and all-cause mortality. J Atheroscler Thromb, 2011; 18: 833-845","DOI":"10.5551\/jat.8094"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) The AIM-HIGH investigators: Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med, 2011; 365: 2255-2267","DOI":"10.1056\/NEJMoa1107579"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Schwartz GG, Olsson AG, Abt M, Ballantyne CM, Barter PJ, Brumm J, Chaitman BR, Holme IM, Kallend D, Leiter LA, Leitersdorf E, McMurray JJV, Mundl H, Nicholls SJ, Shah PK, Tardif JC, Wright RS, for the dal-OUTCOMES Investigators: Effects of Dalcetrapib in Patients with a Recent Acute Coronary Syndrome. N Engl J Med, 2012; 367: 2089-2099","DOI":"10.1056\/NEJMoa1206797"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Voight BF, Peloso GM, Orho-Melander M, FrikkeSchmidt R, Barbalic M, Jensen MK, Hindy G, H\u00f3lm H, Ding EL, Johnson T, Schunkert H, Samani NJ, Clarke R, Hopewell JC, Thompson JF, Li M, Thorleifsson G, Newton-Cheh C, Musunuru K, Pirruccello JP, Saleheen D, Chen L, Stewart A, Schillert A, Thorsteinsdottir U, Thorgeirsson G, Anand S, Engert JC, Morgan T, Spertus J, Stoll M, Berger K, Martinelli N, Girelli D, McKeown PP, Patterson CC, Epstein SE, Devaney J, Burnett MS, Mooser V, Ripatti S, Surakka I, Nieminen MS, Sinisalo J, Lokki ML, Perola M, Havulinna A, de Faire U, Gigante B, Ingelsson E, Zeller T, Wild P, de Bakker PI, Klungel OH, Maitland-van der Zee AH, Peters BJ, de Boer A, Grobbee DE, Kamphuisen PW, Deneer VH, Elbers CC, Onland-Moret NC, Hofker MH, Wijmenga C, Verschuren WM, Boer JM, van der Schouw YT, Rasheed A, Frossard P, Demissie S, Willer C, Do R, Ordovas JM, Abecasis GR, Boehnke M, Mohlke KL, Daly MJ, Guiducci C, Burtt NP, Surti A, Gonzalez E, Purcell S, Gabriel S, Marrugat J, Peden J, Erdmann J, Diemert P, Willenborg C, K\u00f6nig IR, Fischer M, Hengstenberg C, Ziegler A, Buysschaert I, Lambrechts D, Van de Werf F, Fox KA, El Mokhtari NE, Rubin D, Schrezenmeir J, Schreiber S, Sch\u00e4fer A, Danesh J, Blankenberg S, Roberts R, McPherson R, Watkins H, Hall AS, Overvad K, Rimm E, Boerwinkle E, Tybjaerg-Hansen A, Cupples LA, Reilly MP, Melander O, Mannucci PM, Ardissino D, Siscovick D, Elosua R, Stefansson K, O'Donnell CJ, Salomaa V, Rader DJ, Peltonen L, Schwartz SM, Altshuler D, Kathiresan S: Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet, 2012; 380: 572-580","DOI":"10.1016\/S0140-6736(12)60312-2"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Jansen H, Samani NJ, Schunkert H: Mendelian randomization studies in coronary artery disease. Eur Heart J, 2014; 35: 1917-1924","DOI":"10.1093\/eurheartj\/ehu208"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Prospective Studies Collaboration: Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55 000 vascular deaths. Lancet, 2007; 370: 1829-1839","DOI":"10.1016\/S0140-6736(07)61778-4"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Rosenson RS, Brewer HB Jr, Davidson WS, Fayad ZA, Fuster V, Goldstein J, Hellerstein M, Jiang XC, Phillips MC, Rader DJ, Remaley AT, Rothblat GH, Tall AR, Yvan-Charvet L: Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation, 2012; 125: 1905-1919","DOI":"10.1161\/CIRCULATIONAHA.111.066589"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Brewer Jr HB: The evolving role of HDL in the treatment of high-risk patients with cardiovascular disease. J Clin Endocrinol Metab, 2011; 96: 1246-1257","DOI":"10.1210\/jc.2010-0163"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Khera AV, Cuchel M, de la Llera-Moya M, Rodrigues A, Burke MF, Jafri K, French BC, Phillips JA, Mucksavage ML, Wilensky RL, Mohler ER, Rothblat GH, Rader DJ: Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N Engl J Med, 2011; 364: 127-135","DOI":"10.1056\/NEJMoa1001689"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Rohatgi A, Khera A, Berry JD, Givens EG, Ayers CR, Wedin KE, Neeland IJ, Yuhanna IS, Rader DR, de Lemos JA, Shaul PW: HDL cholesterol efflux capacity and incident cardiovascular events. N Engl J Med, 2014; 371: 2383-2393","DOI":"10.1056\/NEJMoa1409065"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Saleheen D, Scott R, Javad S, Zhao W, Rodrigues A, Picataggi A, Lukmanova D, Mucksavage ML, Luben R, Billheimer J, Kastelein JJ, Boekholdt SM, Khaw KT, Wareham N, Rader DJ: Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study. Lancet Diabetes Endocrinol, 2015; 3: 507-513","DOI":"10.1016\/S2213-8587(15)00126-6"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Khera AV, Patel PJ, ReillyMP, Rader DJ: The addition of Niacin to statin therapy improves high-density lipoprotein cholesterol levels but not metrics of functionality. J Am Coll Cardiol, 2013; 62: 1909-1910","DOI":"10.1016\/j.jacc.2013.07.025"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Ozasa H, Ayaori M, Iizuka M, Terao Y, Uto-Kondo H, Yakushiji E, Takiguchi S, Nakaya K, Hisada T, Uehara Y, Ogura M, Sasaki M, Komatsu T, Horii S, Mochizuki S, Yoshimura M, Ikewaki K: Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1\/ABCG1 expressions via PPAR\u03b3\/LXR\u03b1 pathway: findings from in vitro and ex vivo studies. Atherosclerosis, 2011; 219: 141-150","DOI":"10.1016\/j.atherosclerosis.2011.07.113"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Nakaya K, Ayaori M, Hisada T, Sawada S, Tanaka N, Iwamoto N, Ogura M, Yakushiji E, Kusuhara M, Nakamura H, Ohsuzu F: Telmisartan enhances cholesterol efflux from THP-1 macrophages by activating PPARgamma. J Atheroscler Thromb, 2007; 14: 133-141","DOI":"10.5551\/jat.14.133"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Khera AV, Rader DJ: Cholesterol efflux capacity: Full steam ahead or a bump in the road? Arterioscler Thromb Vasc Biol, 2013; 33: 1449-1451","DOI":"10.1161\/ATVBAHA.113.301519"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Kashiwagi A, Kasuga M, Araki E, Oka Y, Hanafusa T, Ito H, Tominaga M, Oikawa S, Noda M, Kawamura T, Sanke T, Namba M, Hashiramoto M, Sasahara T, Nishio Y, Kuwa K, Ueki K, Takei I, Umemoto M, Murakami M, Yamakado M, Yatomi Y, Ohashi H, Committee on the Standardization of Diabetes Mellitus-Related Laboratory Testing of Japan Diabetes Society (JDS): International clinical harmonization of glycated hemoglobin in Japan: From Japan Diabetes Society to National Glycohemoglobin Standardization Program values. Diabetol Int, 2012; 3: 8-10","DOI":"10.1007\/s13340-012-0069-8"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K: Executive Summary of the Japan Atherosclerosis Society (JAS) Guidelines for the Diagnosis and Prevention of Atherosclerotic Cardiovascular Diseases in Japan -2012 Version. J Atheroscler Thromb, 2013; 20: 517-523","DOI":"10.5551\/jat.15792"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Imai E, Horio M, Watanabe T, Iseki K, Yamagata K, Hara S, Ura N, Kiyohara Y, Moriyama T, Ando Y, Fujimoto S, Konta T, Yokoyama H, Makino H, Hishida A, Matsuo S: Prevalence of chronic kidney disease in the Japanese general population. Clin Exp Nephrol, 2009; 13: 621-630","DOI":"10.1007\/s10157-009-0199-x"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Yamashina A, Tomiyama H, Takeda K, Tsuda H, Arai T, Hirose K, Koji Y, Hori S, Yamamoto Y: Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res, 2002; 25: 359-364","DOI":"10.1291\/hypres.25.359"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Nakajima K, Saito K, Tamura A, Suzuki M, Nakano T, Adachi M, Tanaka A, Tada N, Nakamura H, Campos E, Havel RL: Cholesterol in remnant-like lipoproteins in human serum using monoclonal anti apoB-100 and anti apoA-1 immunoaffinity mixed gels. Clin Chim Acta, 1993; 223: 53-71","DOI":"10.1016\/0009-8981(93)90062-9"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Roberts WL, Moulton L, Law TC, Farrow G, Cooper-Anderson M, Savory J, Rifai N: Evaluation of nine automated high-sensitivity C-reactive protein methods: Implications for clinical and epidemiological applications. Part 2.Clin Chem, 2001; 47: 418-425","DOI":"10.1093\/clinchem\/47.3.418"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Beaver WL, Wasserman K, Whipp BJ: A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol, 1986; 60: 2020-2027","DOI":"10.1152\/jappl.1986.60.6.2020"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K: Comprehensive Risk Management for the Prevention of Cardiovascular Disease Executive Summary of the Japan Atherosclerosis Society (JAS) Guidelines for the Diagnosis and Prevention of Atherosclerotic Cardiovascular Diseases in Japan \u2014 2012. J Atheroscler Thromb, 2013; 20: 603-615","DOI":"10.5551\/jat.15867"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014). Hypertens Res 2014; 37: 253-392","DOI":"10.1038\/hr.2014.20"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K: Absolute Risk of Cardiovascular Disease and Lipid Management Targets. Executive Summary of the Japan Atherosclerosis Society (JAS) Guidelines for the Diagnosis and Prevention of Atherosclerotic Cardiovascular Diseases in Japan \u2014 2012 Version. J Atheroscler Thromb, 2013; 20: 689-697","DOI":"10.5551\/jat.17392"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, Goldberg AC, Gordon D, Levy D, Lloyd-Jones DM, McBride P, Schwartz JS, Shero ST, Smith SC Jr, Watson K, Wilson PW, Eddleman KM, Jarrett NM, LaBresh K, Nevo L, Wnek J, Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK, Smith SC Jr, Tomaselli GF: American College of Cardiology\/American Heart Association Task Force on Practice Guidelines: 2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. Circulation, 2014; 129(25 Suppl 2): S1-S45","DOI":"10.1161\/01.cir.0000437738.63853.7a"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Ishikawa T, Ayaori M, Uto-Kondo H, Nakajima T, Mutoh M, Ikewaki K: High-density lipoprotein cholesterol efflux capacity as a relevant predictor of atherosclerotic coronary disease. Atherosclerosis, 2015; 242: 318-322","DOI":"10.1016\/j.atherosclerosis.2015.06.028"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Hafiane A, Jabor B, Ruel I, Ling J, Genest J: High-density lipoprotein mediated cellular cholesterol efflux in acute coronary syndromes. Am J Cradiol, 2014; 113: 249-255","DOI":"10.1016\/j.amjcard.2013.09.006"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Maeda K, Noguchi Y, Fukui T: The effects of cessation from cigarette smoking on the lipid and lipoprotein profiles: a meta-analysis. Prev Med, 2003; 37: 283-290","DOI":"10.1016\/S0091-7435(03)00110-5"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Hambrecht R, Walther C, M\u00f6bius-Winkler S, Gielen S, Linke A, Conradi K, Erbs S, Kluge R, Kendziorra K, Sabri O, Sick P, Schuler G: Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial. Circulation, 2004; 109: 1371-1378","DOI":"10.1161\/01.CIR.0000121360.31954.1F"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Belardinelli R, Paolini I, Cianci G, Piva R, Georgiou D, Purcaro A: Exercise training intervention after coronary angioplasty: the ETICA trial. J Am Coll Cardiol, 2001; 37: 1891-1900","DOI":"10.1016\/S0735-1097(01)01236-0"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Greene NP, Fluckey JD, Lambert BS, Greene ES, Riechman SE, Crouse SF: Regulators of blood lipids and lipoproteins? PPAR\u03b4 and AMPK, induced by exercise, are correlated with lipids and lipoproteins in overweight\/obese men and women. Am J Physiol Endocrinol Metab, 2012; 303: E1212-E1221","DOI":"10.1152\/ajpendo.00309.2012"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Handschin C, Spiegelman BM: The role of exercise and PGC-1\u03b1 in inflammtion and chronic disease. Nature, 2008; 454: 463-469","DOI":"10.1038\/nature07206"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Butcher LR, Thomas A, Backx K, Roberts A, Webb R, Morris K: Low-intensity exercise exerts beneficial effects on plasma lipids via PPARgamma. Med Sci Sports Exerc, 2008; 40: 1263-1270","DOI":"10.1249\/MSS.0b013e31816c091d"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Miyamoto-Sasaki M, Yasuda T, Monguchi T, Nakajima H, Mori K, Toh R, Ishida T, Hirata K: Pitavastatin increases HDL particles functionally preserved with cholesterol efflux capacity and antioxidative actions in dyslipidemic patients. J Atheroscle Thromb, 2013; 20: 708-716","DOI":"10.5551\/jat.17210"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Nicholls SJ, Ruotolo G, Brewer HB, Kane JP, Wang, Krueger KA, Adelman SJ, Nissen SE, Rader DJ: Cholesterol efflux capacity and pre-beta-1 HDL concentrations are increased in dyslipidemic patients treated with evacetrapib. J Am Coll Cardiol, 2015; 66: 2201-2210","DOI":"10.1016\/j.jacc.2015.09.013"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) L\u00fcscher TF, Landmesser U, von Eckardstein A, Fogelman AM: High-Density Lipoprotein. Vascular Protective Effects, Dysfunction, and Potential as Therapeutic Target. Circ Res, 2014; 114: 171-118","DOI":"10.1161\/CIRCRESAHA.114.300935"}],"container-title":["Journal of Atherosclerosis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/23\/7\/23_34454\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T17:22:49Z","timestamp":1600276969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/23\/7\/23_34454\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.5551\/jat.34454","relation":{},"ISSN":["1340-3478","1880-3873"],"issn-type":[{"value":"1340-3478","type":"print"},{"value":"1880-3873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}