{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:42:45Z","timestamp":1790376165843,"version":"4.1.0"},"reference-count":29,"publisher":"Japan Atherosclerosis Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Atheroscler Thromb","JAT"],"published-print":{"date-parts":[[2017]]},"DOI":"10.5551\/jat.35204","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T23:18:41Z","timestamp":1464131921000},"page":"55-67","source":"Crossref","is-referenced-by-count":14,"title":["Beta-adrenoceptor Activation by Norepinephrine Enhances Lipopolysaccharide-induced Matrix Metalloproteinase-9 Expression Through the ERK\/JNK-c-Fos Pathway in Human THP-1 Cells"],"prefix":"10.5551","volume":"24","author":[{"given":"Xiang","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences, First Affiliated Hospital, School of Medicine, Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linli","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Shengzhou People's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, First Affiliated Hospital, School of Medicine, Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, First Affiliated Hospital, School of Medicine, Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, First Affiliated Hospital, School of Medicine, Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, First Affiliated Hospital, School of Medicine, Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, First Affiliated Hospital, School of Medicine, Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, First Affiliated Hospital, School of Medicine, Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangrong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, First Affiliated Hospital, School of Medicine, Zhejiang University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3489","reference":[{"key":"1","unstructured":"1) Shah PK, Falk E, Badimon JJ, Fernandez-Ortiz A, Mailhac A, Villareal-Levy G, Fallon JT, Regnstrom J, Fuster V. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture. Circulation 1995; 92: 1565-1569"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Heo SH, Cho CH, Kim HO, Jo YH, Yoon KS, Lee JH, Park JC, Park KC, Ahn TB, Chung KC and others. Plaque rupture is a determinant of vascular events in carotid artery atherosclerotic disease: involvement of matrix metalloproteinases 2 and 9. J Clin Neurol 2011; 7: 69-76","DOI":"10.3988\/jcn.2011.7.2.69"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) De Paoli F, Eeckhoute J, Copin C, Vanhoutte J, Duhem C, Derudas B, Dubois-Chevalier J, Colin S, Zawadzki C, Jude B and others. The neuron-derived orphan receptor 1 (NOR1)is induced upon human alternative macrophage polarization and stimulates the expression of markers of the M2 phenotype. Atherosclerosis 2015; 241: 18-26","DOI":"10.1016\/j.atherosclerosis.2015.04.798"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Stintzing S, Heuschmann P, Barbera L, Ocker M, Jung A, Kirchner T, Neureiter D. Overexpression of MMP9 and tissue factor in unstable carotid plaques associated with Chlamydia pneumoniae, inflammation, and apoptosis. Ann Vasc Surg 2005; 19: 310-319","DOI":"10.1007\/s10016-005-0003-7"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Andoh Y, Ogura H, Satoh M, Shimano K, Okuno H, Fujii S, Ishimori N, Eshima K, Tamauchi H, Otani T and others. Natural killer T cells are required for lipopolysaccharide-mediated enhancement of atherosclerosis in apolipoprotein E-deficient mice. Immunobiology 2013; 218: 561-569","DOI":"10.1016\/j.imbio.2012.07.022"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) den Dekker WK, Cheng C, Pasterkamp G, Duckers HJ. Toll like receptor 4 in atherosclerosis and plaque destabilization. Atherosclerosis 2010; 209: 314-320","DOI":"10.1016\/j.atherosclerosis.2009.09.075"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Schoneveld AH, Hoefer I, Sluijter JP, Laman JD, de Kleijn DP, Pasterkamp G. Atherosclerotic lesion development and Toll like receptor 2 and 4 responsiveness. Atherosclerosis 2008; 197: 95-104","DOI":"10.1016\/j.atherosclerosis.2007.08.004"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Chistiakov DA, Ashwell KW, Orekhov AN, Bobryshev YV. Innervation of the arterial wall and its modification in atherosclerosis. Auton Neurosci 2015","DOI":"10.1016\/j.autneu.2015.06.005"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Chen S, Du C, Shen M, Zhao G, Xu Y, Yang K, Wang X, Li F, Zeng D, Chen F and others. Sympathetic stimulation facilitates thrombopoiesis by promoting megakaryocyte adhesion, migration, and proplatelet formation. Blood 2016; 127: 1024-1035","DOI":"10.1182\/blood-2015-07-660746"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Kaynar AM, Yende S, Zhu L, Frederick DR, Chambers R, Burton CL, Carter M, Stolz DB, Agostini B, Gregory AD and others. Effects of intra-abdominal sepsis on atherosclerosis in mice. Crit Care 2014; 18: 469","DOI":"10.1186\/s13054-014-0469-1"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Vacek TP, Rehman S, Neamtu D, Yu S, Givimani S, Tyagi SC. Matrix metalloproteinases in atherosclerosis: role of nitric oxide, hydrogen sulfide, homocysteine, and polymorphisms. Vasc Health Risk Manag 2015; 11: 173-183","DOI":"10.2147\/VHRM.S68415"},{"key":"12","unstructured":"12) Hopps E, Caimi G. Matrix metalloproteases as a pharmacological target in cardiovascular diseases. Eur Rev Med Pharmacol Sci 2015; 19: 2583-2589"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Noji Y, Kajinami K, Kawashiri MA, Todo Y, Horita T, Nohara A, Higashikata T, Inazu A, Koizumi J, Takegoshi T and others. Circulating matrix metalloproteinases and their inhibitors in premature coronary atherosclerosis. Clin Chem Lab Med 2001; 39: 380-384","DOI":"10.1515\/CCLM.2001.060"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res 2002; 90: 251-262","DOI":"10.1161\/res.90.3.251"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Jones CB, Sane DC, Herrington DM. Matrix metalloproteinases: a review of their structure and role in acute coronary syndrome. Cardiovasc Res 2003; 59: 812-823","DOI":"10.1016\/S0008-6363(03)00516-9"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Bourboulia D, Stetler-Stevenson WG. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion. Semin Cancer Biol 2010; 20: 161-168","DOI":"10.1016\/j.semcancer.2010.05.002"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Yu X, Jia B, Wang F, Lv X, Peng X, Wang Y, Li H, Wang Y, Lu D, Wang H. alpha(1) adrenoceptor activation by norepinephrine inhibits LPS-induced cardiomyocyte TNF-alpha production via modulating ERK1\/2 and NF-kappaB pathway. J Cell Mol Med 2014; 18: 263-273","DOI":"10.1111\/jcmm.12184"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Huang J, Zhang Y, Wang C, Zhou J, Ma Q, Wang X, Shen X, Jiang C. Enhanced Phosphorylation of MAPKs by NE Promotes TNF-?? Production by Macrophage Through ?? Adrenergic Receptor. Inflammation 2012; 35: 527-534","DOI":"10.1007\/s10753-011-9342-4"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Speidl WS, Toller WG, Kaun C, Weiss TW, Pfaffenberger S, Kastl SP, Furnkranz A, Maurer G, Huber K, Metzler H and others. Catecholamines potentiate LPS-induced expression of MMP-1 and MMP-9 in human monocytes and in the human monocytic cell line U937: possible implications for peri-operative plaque instability. Faseb J 2004; 18: 603-605","DOI":"10.1096\/fj.03-0454fje"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Mittal B, Mishra A, Srivastava A, Kumar S, Garg N. Matrix metalloproteinases in coronary artery disease. Adv Clin Chem 2014; 64: 1-72","DOI":"10.1016\/B978-0-12-800263-6.00001-X"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Rietz A, Spiers JP. The relationship between the MMP system, adrenoceptors and phosphoprotein phosphatases. Brit J Pharmacol 2012; 166: 1225-1243","DOI":"10.1111\/j.1476-5381.2012.01917.x"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Hori Y, Kunihiro S, Sato S, Yoshioka K, Hara Y, Kanai K, Hoshi F, Itoh N, Higuchi S. Doxycycline attenuates isoproterenol-induced myocardial fibrosis and matrix metalloproteinase activity in rats. Biol Pharm Bull 2009; 32: 1678-1682","DOI":"10.1248\/bpb.32.1678"},{"key":"23","doi-asserted-by":"crossref","unstructured":"24) Arai K, Lee SR, Lo EH. Essential role for ERK mitogenactivated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytes. Glia 2003; 43: 254-264","DOI":"10.1002\/glia.10255"},{"key":"24","doi-asserted-by":"crossref","unstructured":"25) Underwood DC, Osborn RR, Bochnowicz S, Webb EF, Rieman DJ, Lee JC, Romanic AM, Adams JL, Hay DW, Griswold DE. SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung. Am J Physiol Lung Cell Mol Physiol 2000; 279: L895-L902","DOI":"10.1152\/ajplung.2000.279.5.L895"},{"key":"25","doi-asserted-by":"crossref","unstructured":"26) Woo CH, Lim JH, Kim JH. Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells. J Immunol 2004; 173: 6973-6980","DOI":"10.4049\/jimmunol.173.11.6973"},{"key":"26","doi-asserted-by":"crossref","unstructured":"27) Xiao YQ, Malcolm K, Worthen GS, Gardai S, Schiemann WP, Fadok VA, Bratton DL, Henson PM. Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta. J Biol Chem 2002; 277: 14884-14893","DOI":"10.1074\/jbc.M111718200"},{"key":"27","doi-asserted-by":"crossref","unstructured":"28) Liu W, Chang L. Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+\/ROS-mediated suppression of ERK\/c-fos pathway and activation of p38 MAPK\/c-jun pathway. J Cell Physiol 2010; 224: 775-785","DOI":"10.1002\/jcp.22180"},{"key":"28","doi-asserted-by":"crossref","unstructured":"29) Lai WC, Zhou M, Shankavaram U, Peng G, Wahl LM. Differential regulation of lipopolysaccharide-induced monocyte matrix metalloproteinase (MMP)-1 and MMP-9 by p38 and extracellular signal-regulated kinase 1\/2 mitogen-activated protein kinases. J Immunol 2003; 170: 6244-6249","DOI":"10.4049\/jimmunol.170.12.6244"},{"key":"29","doi-asserted-by":"crossref","unstructured":"30) Dziembowska M, Wlodarczyk J. MMP9: a novel function in synaptic plasticity. Int J Biochem Cell Biol 2012; 44: 709-713","DOI":"10.1016\/j.biocel.2012.01.023"}],"container-title":["Journal of Atherosclerosis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/24\/1\/24_35204\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T19:51:45Z","timestamp":1567972305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/24\/1\/24_35204\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.5551\/jat.35204","relation":{},"ISSN":["1340-3478","1880-3873"],"issn-type":[{"value":"1340-3478","type":"print"},{"value":"1880-3873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}