{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:27:40Z","timestamp":1765758460146},"reference-count":35,"publisher":"Japan Atherosclerosis Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Atheroscler Thromb","JAT"],"published-print":{"date-parts":[[2017]]},"DOI":"10.5551\/jat.36434","type":"journal-article","created":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T22:08:19Z","timestamp":1477951699000},"page":"696-705","source":"Crossref","is-referenced-by-count":23,"title":["Impact of Homocysteine Level on Long-term Cardiovascular Outcomes in Patients after Coronary Artery Stenting"],"prefix":"10.5551","volume":"24","author":[{"given":"Jih-Kai","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Cardiology, Percutaneous Coronary Intervention Center, Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Percutaneous Coronary Intervention Center, Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Jer","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Percutaneous Coronary Intervention Center, Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Lung","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Percutaneous Coronary Intervention Center, Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hung","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Percutaneous Coronary Intervention Center, Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Percutaneous Coronary Intervention Center, Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Hung","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Percutaneous Coronary Intervention Center, Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Yung","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Percutaneous Coronary Intervention Center, Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Hung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Percutaneous Coronary Intervention Center, Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-Chang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Percutaneous Coronary Intervention Center, Chang Gung Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3489","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Elezi S, Kastrati A, Pache J, Wehinger A, Hadamitzky M, Dirschinger J, Neumann FJ, Sch\u00f6mig A: Diabetes mellitus and the clinical and angiographic outcome after coronary stent placement. J Am Coll Cardiol. 1998; 32: 1866-1873","DOI":"10.1016\/S0735-1097(98)00467-7"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Abizaid A, Kornowski R, Mintz GS, Hong MK, Abizaid AS, Mehran R, Pichard AD, Kent KM, Satler LF, Wu H, Popma JJ, Leon MB: The influence of diabetes mellitus on acute and late clinical outcomes following coronary stent implantation. J Am Coll Cardiol. 1998; 32: 584-589","DOI":"10.1016\/S0735-1097(98)00286-1"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Wald DS, Law M, Morris JK: Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis.BMJ. 2002; 325: 1202","DOI":"10.1136\/bmj.325.7374.1202"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Schaffer A, Verdoia M, Cassetti E, Marino P, Suryapranata H, De Luca G; Novara Atherosclerosis Study Group (NAS): Relationship between homocysteine and coronary artery disease. Results from a large prospective cohort study. Thromb Res. 2014; 134: 288-293","DOI":"10.1016\/j.thromres.2014.05.025"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Homocysteine Studies Collaboration: Homocysteine and risk of ischemic heart disease and stroke. JAMA. 2002; 288: 2015-2022","DOI":"10.1001\/jama.288.16.2015"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Casas JP, Bautista LE, Smeeth L, Sharma P, Hingorani AD: Homocysteine and stroke: evidence on a causal link from mendelian randomisation. Lancet. 2005; 365: 224-232","DOI":"10.1016\/S0140-6736(05)17742-3"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG; MTHFR Studies Collaboration Group. MTHFR 677 C \u2192 T polymorphism and risk of coronary heart disease. JAMA. 2002; 288: 2023-2031","DOI":"10.1001\/jama.288.16.2023"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) den Heijer M, Koster T, Blom HJ, Bos GM, Briet E, Reitsma PH, Vandenbroucke JP, Rosendaal FR: Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med. 1996; 334: 759-762","DOI":"10.1056\/NEJM199603213341203"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Morita H, Kurihara H, Yoshida S, Saito Y, Shindo T, OhHashi Y, Kurihara Y, Yazaki Y, Nagai R: Diet-induced hyperhomocysteinemia exacerbates neointima formation in rat carotid arteries after balloon injury. Circulation. 2001; 103: 133-139","DOI":"10.1161\/01.CIR.103.1.133"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Schnyder G, Roffi M, Flammer Y, Pin R, Hess OM: Association of plasma homocysteine with restenosis after percutaneous coronary angioplasty. Eur Heart J. 2002; 23: 726-733","DOI":"10.1053\/euhj.2001.2962"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Schnyder G, Flammer Y, Roffi M, Pin R, Hess OM: Plasma homocysteine levels and late outcome after coronary angioplasty. J Am Coll Cardiol. 2002; 40: 1769-1776","DOI":"10.1016\/S0735-1097(02)02481-6"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Zairis MN, Ambrose JA, Manousakis SJ, Stefanidis AS, Papadaki OA, Bilianou HI, DeVoe MC, Fakiolas CN, Pissimissis EG, Olympios CD, Foussas SG: The impact of plasma levels of C-reactive protein, lipoprotein (a) and homocysteine on the long-term prognosis after successful coronary stenting. J Am Coll Cardiol. 2002; 40: 1375-1382","DOI":"10.1016\/S0735-1097(02)02267-2"},{"key":"13","unstructured":"13) Mccully KS: Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol. 1969; 56: 111-128"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Arnesen E, Refsum H, B\u00f8naa KH, Ueland PM, F\u00f8rde OH, Nordrehaug JE: Serum total homocysteine and coronary heart disease. Int J Epidemiol. 1995; 24: 704-709","DOI":"10.1093\/ije\/24.4.704"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Malinow MR, Nieto FJ, Szklo M, Chambless LE, Bond G: Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The atherosclerosis risk in communities study. Circulation. 1993; 87: 1107-1113","DOI":"10.1161\/01.CIR.87.4.1107"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Ridker PM, Hennekens CH, Selhub J, Miletich JP, Malinow MR, Stampfer MJ: Interrelation of hyperhomocyst(e)inemia, factor v leiden, and risk of future venous thromboembolism. Circulation. 1997; 95: 1777-1782","DOI":"10.1161\/01.CIR.95.7.1777"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Tawakol A, Omland T, Gerhard M, Wu JT, Creager MA: Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation. 1997; 95: 1119-1121","DOI":"10.1161\/01.CIR.95.5.1119"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Majors A, Ehrhart LA, Pezacka EH: Homocysteine as a risk factor for vascular disease: Enhanced collagen production and accumulation by smooth muscle cells. Arterioscler Thromb Vasc Biol. 1997; 17: 2074-2081","DOI":"10.1161\/01.ATV.17.10.2074"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Bellamy MF, McDowell IF: Putative mechanisms for vascular damage by homocysteine. J Inherit Metab Dis. 1997; 20: 307-315","DOI":"10.1023\/A:1005377310872"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) M. Cheng, H. Ho, J. Lin, Y. Chen, E. Chan, and D. T. Chiu: Clinical relevance of plasma homocysteine levels in Taiwanese patients with coronary artery disease. Biofactors. 2008; 34: 125-134","DOI":"10.1002\/biof.5520340204"},{"key":"21","doi-asserted-by":"crossref","unstructured":"22) O. Tang, J. Wu, and F. Qin: Relationship between methylenetetrahydrofolate reductase gene polymorphism and the coronary slow flow phenomenon. Coron. Artery Dis. 2014; 25: 653-657","DOI":"10.1097\/MCA.0000000000000151"},{"key":"22","doi-asserted-by":"crossref","unstructured":"23) H. Tanriverdi, H. Evrengul, Y. Enli, O. Kuru, D. Seleci, S. Tanriverdi, N. Tuzun, H. A. Kaftan, and N. Karabulut: Effect of homocysteine-induced oxidative stress on endothelial function in coronary slow-flow. Cardiology. 2007; 107: 313-320","DOI":"10.1159\/000099068"},{"key":"23","doi-asserted-by":"crossref","unstructured":"24) C. L. Chao, H. H. Tsai, C. M. Lee, S. M. Hsu, J. T. Kao, K. L.Chien, F. C. Sung, and Y. T. Lee: The graded effect of hyperhomocysteinemia on the severity and extent of coronary atherosclerosis. Atherosclerosis. 1999; 147: 379-386","DOI":"10.1016\/S0021-9150(99)00208-7"},{"key":"24","unstructured":"25) N. Hirose, Y. Arai, T. Ishii, M. Tushima, and J. Li: Association of mild hyperhomocysteinemia with aortic calcification in hypercholesterolemic patients. J. Atheroscler. Thromb. 2001; 8: 91-94"},{"key":"25","doi-asserted-by":"crossref","unstructured":"26) J. Li, S. Chai, C. Tang, and J. Du: Homocysteine potentiates calcification of cultured rat aortic smooth muscle cells. Life Sci. 2003; 74: 451-461","DOI":"10.1016\/j.lfs.2003.06.028"},{"key":"26","doi-asserted-by":"crossref","unstructured":"27) H. Xu, C. Liu, and Q. Wang: Plaque image characteristics, hyperhomocysteinemia, and gene polymorphism of homocysteine metabolism-related enzyme (MTHFR C677T) in acute coronary syndrome. Cell Biochem. Biophys.2013; 2: 403-407","DOI":"10.1007\/s12013-012-9483-6"},{"key":"27","unstructured":"28) J. L. Duan, T. Murohara, H. Ikeda, K. Sasaki, S. Shintani, T. Akita, T. Shimada, and T. Imaizumi: Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia. Arterioscler. Thromb. Vasc. Biol. 2000; 20: 2579-2585"},{"key":"28","doi-asserted-by":"crossref","unstructured":"29) Kosokabe T, Okumura K, Sone T, Kondo J, Tsuboi H, Mukawa H, Tomida T, Suzuki T, Kamiya H, Matsui H, Hayakawa T: Relation of a common methylenetetrahydrofolate reductase mutation and plasma homocysteine with intimal hyperplasia after coronary stenting. Circulation. 2001; 103: 2048-2054","DOI":"10.1161\/01.CIR.103.16.2048"},{"key":"29","doi-asserted-by":"crossref","unstructured":"30) Nyg\u00e5rd O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE: Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med. 1997; 337: 230-236","DOI":"10.1056\/NEJM199707243370403"},{"key":"30","doi-asserted-by":"crossref","unstructured":"31) Stubbs PJ, Al-Obaidi MK, Conroy RM, Collinson PO, Graham IM, Noble IM: Effect of plasma homocysteine concentration on early and late events in patients with acute coronary syndromes. Circulation. 2000; 102: 605-610","DOI":"10.1161\/01.CIR.102.6.605"},{"key":"31","unstructured":"32) Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, McQueen MJ, Probstfield J, Fodor G, Held C, Genest J Jr; Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators: Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med. 2006; 354: 1567-1578"},{"key":"32","doi-asserted-by":"crossref","unstructured":"33) B\u00f8naa KH, Nj\u00f8lstad I, Ueland PM, Schirmer H, Tverdal A, Steigen T, Wang H, Nordrehaug JE, Arnesen E, Rasmussen K; NORVIT Trial Investigators: Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med. 2006; 354: 1578-1588","DOI":"10.1056\/NEJMoa055227"},{"key":"33","doi-asserted-by":"crossref","unstructured":"34) Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, Sides EG, Wang CH, Stampfer M: Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA. 2004; 291: 565-575","DOI":"10.1001\/jama.291.5.565"},{"key":"34","doi-asserted-by":"crossref","unstructured":"35) Qin X, Huo Y, Xie D, Hou F, Xu X, Wang X: Homocysteine-lowering therapy with folic acid is effective in cardiovascular disease prevention in patients with kidney disease: a meta-analysis of randomized controlled trials. Clin Nutr. 2013; 32: 722-727","DOI":"10.1016\/j.clnu.2012.12.009"},{"key":"35","doi-asserted-by":"crossref","unstructured":"36) M. V. Holmes, P. Newcombe, J. A. Hubacek, R. Sofat, S. L. Ricketts, J. Cooper, M. M. Breteler, L. E. Bautista, P. Sharma, J. C. Whittaker, L. Smeeth, F. G. R. Fowkes, A. Algra, V. Shmeleva, Z. Szolnoki, M. Roest, M. Linnebank, J. Zacho, M. A. Nalls, A. B. Singleton, L. Ferrucci, J. Hardy, B. B. Worrall, S. S. Rich, M. Matarin, P. E. Norman, L. Flicker, O. P. Almeida, F. M. Van Bockxmeer, H. Shimokata, K. T. Khaw, N. J. Wareham, M. Bobak, J. A. C.Sterne, G. D. Smith, P. J. Talmud, C. Van Duijn, S. E. Humphries, J. F. Price, S. Ebrahim, D. A. Lawlor, G. J. Hankey, J. F. Meschia, M. S. Sandhu, A. D. Hingorani, and J. P. Casas: Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: A meta-analysis of genetic studies and randomised trials. Lancet. 2011; 378: 584-594","DOI":"10.1016\/S0140-6736(11)60872-6"}],"container-title":["Journal of Atherosclerosis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/24\/7\/24_36434\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T05:21:32Z","timestamp":1568524892000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/24\/7\/24_36434\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.5551\/jat.36434","relation":{},"ISSN":["1340-3478","1880-3873"],"issn-type":[{"value":"1340-3478","type":"print"},{"value":"1880-3873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}