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N Engl J Med, 2008; 359: 2195-2207","DOI":"10.1056\/NEJMoa0807646"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Koga J, Matoba T, Egashira K: Anti-inflammatory Nanoparticle for Prevention of Atherosclerotic Vascular Diseases. J Atheroscler Thromb, 2016; 23: 757-765","DOI":"10.5551\/jat.35113"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Usman A, Ribatti D, Sadat U, Gillard JH: From Lipid Retention to Immune-Mediate Inflammation and Associated Angiogenesis in the Pathogenesis of Atherosclerosis. J Atheroscler Thromb, 2015; 22: 739-749","DOI":"10.5551\/jat.30460"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Eguchi K, Manabe I: Toll-Like Receptor, Lipotoxicity and Chronic inflammation: The Pathological Link Between Obesity and Cardiometabolic Disease. J Atheroscler Thromb, 2014; 21: 629-639","DOI":"10.5551\/jat.22533"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Ross R: Atherosclerosis--an inflammatory disease. N Engl J Med, 1999; 340: 115-126","DOI":"10.1056\/NEJM199901143400207"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Libby P, Lichtman AH, Hansson GK: Immune effector mechanisms implicated in atherosclerosis: from mice to humans. Immunity, 2013; 38: 1092-1104","DOI":"10.1016\/j.immuni.2013.06.009"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Yodoi K, Yamashita T, Sasaki N, Kasahara K, Emoto T, Matsumoto T, Kita T, Sasaki Y, Mizoguchi T, Sparwasser T, Hirata K: Foxp3+ regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice. Hypertension, 2015; 65: 889-895","DOI":"10.1161\/HYPERTENSIONAHA.114.04934"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Kita T, Yamashita T, Sasaki N, Kasahara K, Sasaki Y, Yodoi K, Takeda M, Nakajima K, Hirata K: Regression of atherosclerosis with anti-CD3 antibody via augmenting a regulatory T-cell response in mice. Cardiovsac Res, 2014; 102: 107-117","DOI":"10.1093\/cvr\/cvu002"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9) Kasahara K, Sasaki N, Yamashita T, Kita T, Yodoi K, Sasaki Y, Takeda M, Hirata K: CD3 antibody and IL-2 complex combination therapy inhibits atherosclerosis by augmenting a regulatory immune response. J Am Heart Assoc, 2014; 3: e000719. doi: 10.1161\/JAHA.113.000719","DOI":"10.1161\/JAHA.113.000719"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Nakajima K, Yamashita T, Kita T, Takeda M, Sasaki N, Kasahara K, Shinohara M, Rikitake Y, Ishida T, Yokoyama M, Hirata K: Orally administered eicosapentaenoic acid induces rapid regression of atherosclerosis via modulating the phenotype of dendritic cells in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol, 2011; 31: 1963-1972","DOI":"10.1161\/ATVBAHA.111.229443"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Sasaki N, Yamashita T, Takeda M, Shinohara M, Nakajima K, Tawa H, Usui T, Hirata K: Oral anti-CD3 antibody treatment induces regulatory T cells and inhibits the development of atherosclerosis in mice. Circulation, 2009; 120: 1996-2005","DOI":"10.1161\/CIRCULATIONAHA.109.863431"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Takeda M, Yamashita T, Sasaki N, Nakajima K, Kita T, Shinohara M, Ishida T, Hirata K: Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions. Arterioscler Thromb Vasc Biol, 2010; 30: 2495-2503","DOI":"10.1161\/ATVBAHA.110.215459"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Round JL, Mazmanian SK: The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol, 2009; 9: 313-323","DOI":"10.1038\/nri2515"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Weiner HL, da Cunha AP, Quintana F, Wu H: Oral tolerance. Immunol Rev, 2011; 241: 241-259","DOI":"10.1111\/j.1600-065X.2011.01017.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Ochi H, Abraham M, Ishikawa H, Frenkel D, Yang K, Basso AS, Wu H, Chen ML, Gandhi R, Miller A, Maron R, Weiner HL: Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25- LAP+ T cells. Nat Med, 2006; 12: 627-635","DOI":"10.1038\/nm1408"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Ishikawa H, Ochi H, Chen ML, Frenkel D, Maron R, Weiner HL: Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody. Diabetes, 2007; 56: 2103-2109","DOI":"10.2337\/db06-1632"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Human Microbiome Project Consortium: Structure, function and diversity of the healthy human microbiome. Nature, 2012; 486: 207-214","DOI":"10.1038\/nature11234"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto JM, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, Hansen T, Hattori M, Hayashi T, Kleerebezem M, Kurokawa K, Leclerc M, Levenez F, Manichanh C, Nielsen HB, Nielsen T, Pons N, Poulain J, Qin J, Sicheritz-Ponten T, Tims S, Torrents D, Ugarte E, Zoetendal EG, Wang J, Guarner F, Pedersen O, de Vos WM, Brunak S, Dor\u00e9 J; MetaHIT Consortium, Antol\u00edn M, Artiguenave F, Blottiere HM, Almeida M, Brechot C, Cara C, Chervaux C, Cultrone A, Delorme C, Denariaz G, Dervyn R, Foerstner KU, Friss C, van de Guchte M, Guedon E, Haimet F, Huber W, van Hylckama-Vlieg J, Jamet A, Juste C, Kaci G, Knol J, Lakhdari O, Layec S, Le Roux K, Maguin E, M\u00e9rieux A, Melo Minardi R, M&apos;rini C, Muller J, Oozeer R, Parkhill J, Renault P, Rescigno M, Sanchez N, Sunagawa S, Torrejon A, Turner K, Vandemeulebrouck G, Varela E, Winogradsky Y, Zeller G, Weissenbach J, Ehrlich SD, Bork P: Enterotypes of the human gut microbiome. 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Nature, 2013; 498: 99-103","DOI":"10.1038\/nature12198"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Sato J, Kanazawa A, Ikeda F, Yoshihara T, Goto H, Abe H, Komiya K, Kawaguchi M, Shimizu T, Ogihara T, Tamura Y, Sakurai Y, Yamamoto R, Mita T, Fujitani Y, Fukuda H, Nomoto K, Takahashi T, Asahara T, Hirose T, Nagata S, Yamashiro Y, Watada H: Gut dysbiosis and detection of \u201clive gut bacteria\u201d in blood of Japanese patients with type 2 diabetes. Diabetes Care, 2014; 37: 2343-2350","DOI":"10.2337\/dc13-2817"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Dao MC, Everard A, Aron-Wisnewsky J, Sokolovska N, Prifti E, Verger EO, Kayser BD, Levenez F, Chilloux J, Hoyles L; MICRO-Obes Consortium, Dumas ME, Rizkalla SW, Dor\u00e9 J, Cani PD, Cl\u00e9ment K: Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut, 2016; 65: 426-436","DOI":"10.1136\/gutjnl-2014-308778"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL: Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature, 2011; 472: 57-63","DOI":"10.1038\/nature09922"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL: Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med, 2013; 368: 1575-1584","DOI":"10.1056\/NEJMoa1109400"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Tang WH, Hazen SL: The contributory role of gut microbiota in cardiovascular disease. J Clin Invest, 2016; 124: 4204-4211","DOI":"10.1172\/JCI72331"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Wang Z, Roberts AB, Buffa JA, Levison BS, Zhu W, Org E, Gu X, Huang Y, Zamanian-Daryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis AJ, Hazen SL: Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis. Cell, 2015; 163: 1585-1595","DOI":"10.1016\/j.cell.2015.11.055"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL: Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med, 2013; 19: 576-585","DOI":"10.1038\/nm.3145"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Koeth RA, Levison BS, Culley MK, Buffa JA, Wang Z, Gregory JC, Org E, Wu Y, Li L, Smith JD, Tang WH, DiDonato JA, Lusis AJ, Hazen SL: \u03b3-butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metab, 2014; 20: 799-812","DOI":"10.1016\/j.cmet.2014.10.006"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Wright SD, Burton C, Hernandez M, Hassing H, Montenegro J, Mundt S, Patel S, Card DJ, Hermanowski-Vosatka A, Bergstrom JD, Sparrow CP, Detmers PA, Chao YS: Infectious agents are not necessary for murine atherogenesis. J Exp Med, 2000; 191: 1437-1442","DOI":"10.1084\/jem.191.8.1437"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Stepankova R, Tonar Z, Bartova J, Nedorost L, Rossman P, Poledne R, Schwarzer M, Tlaskalova-Hogenova H: Absence of microbiota (germ-free conditions) accelerates the atherosclerosis in ApoE-deficient mice fed standard low cholesterol diet. J Atheroscler Thromb, 2010; 17: 796-804","DOI":"10.5551\/jat.3285"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Velagapudi VR, Hezaveh R, Reigstad CS, Gopalacharyulu P, Yetukuri L, Islam S, Felin J, Perkins R, Bor\u00e9n J, Oresic M, B\u00e4ckhed F: The gut microbiota modulates host energy and lipid metabolism in mice. J Lipid Res, 2010; 51: 1101-1112","DOI":"10.1194\/jlr.M002774"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Karlsson FH, Fak F, Nookaew I, Tremaroli V, Fagerberg B, Petranovic D, B\u00e4ckhed F, Nielsen J: Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat Commun, 2012; 3: 1245","DOI":"10.1038\/ncomms2266"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Emoto T, Yamashita T, Sasaki N, Hirota Y, Hayashi T, So A, Kasahara K, Yodoi K, Matsumoto T, Mizoguchi T, Ogawa W, Hirata K: Analysis of Gut Microbiota in Coronary Artery Disease Patients: a Possible Link between Gut Microbiota and Coronary Artery Disease. 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