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Sci Rep, 2016; 6: 31130","DOI":"10.1038\/srep31130"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Hosoo S, Koyama M, Kato M, Hirata T, Yamaguchi Y, Yamasaki H, Wada A, Wada K, Nishibe S, Nakamura K: The Restorative Effects of Eucommia ulmoides Oliver Leaf Extract on Vascular Function in Spontaneously Hypertensive Rats. Molecules (Basel, Switzerland), 2015; 20: 21971-21981","DOI":"10.3390\/molecules201219826"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Yaykasli KO, Oohashi T, Hirohata S, Hatipoglu OF, Inagawa K, Demircan K, Ninomiya Y: ADAMTS9 activation by interleukin 1 beta via NFATc1 in OUMS-27 chondrosarcoma cells and in human chondrocytes. Mol Cell Biochem, 2009; 323: 69-79","DOI":"10.1007\/s11010-008-9965-4"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Cilek MZ, Hirohata S, Faruk Hatipoglu O, Ogawa H, Miyoshi T, Inagaki J, Ohtsuki T, Harada H, Kamikawa S, Kusachi S, Ninomiya Y: AHR, a novel acute hypoxiaresponse sequence, drives reporter gene expression under hypoxia in vitro and in vivo. Cell Biol Int, 2011; 35: 1-8","DOI":"10.1042\/CBI20100290"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Demircan K, Gunduz E, Gunduz M, Beder LB, Hirohata S, Nagatsuka H, Cengiz B, Cilek MZ, Yamanaka N, Shimizu K, Ninomiya Y: Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer. 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Nutr Metab Cardiovasc Dis, 2011; 21: 485-491","DOI":"10.1016\/j.numecd.2009.11.015"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Nakano A, Inoue N, Sato Y, Nishimichi N, Takikawa K, Fujita Y, Kakino A, Otsui K, Yamaguchi S, Matsuda H, Sawamura T: LOX-1 mediates vascular lipid retention under hypertensive state. J Hypertens, 2010; 28: 1273-1280","DOI":"10.1097\/HJH.0b013e32833835d4"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Goland S, Shimoni S, Zornitzki T, Knobler H, Azoulai O, Lutaty G, Melzer E, Orr A, Caspi A, Malnick S: Cardiac abnormalities as a new manifestation of nonalcoholic fatty liver disease: echocardiographic and tissue Doppler imaging assessment. J Clin Gastroenterol, 2006; 40: 949-955","DOI":"10.1097\/01.mcg.0000225668.53673.e6"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Lautamaki R, Borra R, Iozzo P, Komu M, Lehtimaki T, Salmi M, Jalkanen S, Airaksinen KE, Knuuti J, Parkkola R, Nuutila P: Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes. Am J Physiol Endocrinol Metab, 2006; 291: E282-290","DOI":"10.1152\/ajpendo.00604.2005"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Fallo F, Dalla Pozza A, Sonino N, Lupia M, Tona F, Federspil G, Ermani M, Catena C, Soardo G, Di Piazza L, Bernardi S, Bertolotto M, Pinamonti B, Fabris B, Sechi LA: Non-alcoholic fatty liver disease is associated with left ventricular diastolic dysfunction in essential hypertension. 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Sci Rep, 2016; 6: 24580","DOI":"10.1038\/srep24580"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Fujita K, Nozaki Y, Wada K, Yoneda M, Fujimoto Y, Fujitake M, Endo H, Takahashi H, Inamori M, Kobayashi N, Kirikoshi H, Kubota K, Saito S, Nakajima A: Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis. Hepatology, 2009; 50: 772-780","DOI":"10.1002\/hep.23094"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Ikeda K, Nara Y, Tagami M, Yamori Y: Nitric oxide deficiency induces myocardial infarction in hypercholesterolaemic stroke-prone spontaneously hypertensive rats. 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