{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T16:58:38Z","timestamp":1779209918321,"version":"3.51.4"},"reference-count":51,"publisher":"Japan Atherosclerosis Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Atheroscler Thromb","JAT"],"published-print":{"date-parts":[[2018]]},"DOI":"10.5551\/jat.41095","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T22:09:53Z","timestamp":1504044593000},"page":"153-169","source":"Crossref","is-referenced-by-count":19,"title":["Effects of Cardiac Rehabilitation on High-Density Lipoprotein-mediated Cholesterol Efflux Capacity and Paraoxonase-1 Activity in Patients with Acute Coronary Syndrome"],"prefix":"10.5551","volume":"25","author":[{"given":"Fumiaki","family":"Furuyama","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Showa University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Koba","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Showa University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Yokota","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Showa University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiyoshi","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Showa University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Shoji","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Showa University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youichi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Showa University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3489","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Brewer Jr HB: The evolving role of HDL in the treatment of high-risk patients with cardiovascular disease. J Clin Endocrinol Metab, 2011; 96: 1246-1257","DOI":"10.1210\/jc.2010-0163"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Rosenson RS, Brewer HB Jr, Davidson WS, Fayad ZA, Fuster V, Goldstein J, Hellerstein M, Jiang XC, Phillips MC, Rader DJ, Remaley AT, Rothblat GH, Tall AR, Yvan-Charvet L: Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport. Circulation, 2012; 125: 1905-1919","DOI":"10.1161\/CIRCULATIONAHA.111.066589"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Khera AV, Cuchel M, de la Llera-Moya M, Rodrigues A, Burke MF, Jafri K, French BC, Phillips JA, Mucksavage ML, Wilensky RL, Mohler ER, Rothblat GH, Rader DJ: Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis. N Engl J Med, 2011; 364: 127-135","DOI":"10.1056\/NEJMoa1001689"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Rohatgi A, Khera A, Berry JD, Givens EG, Ayers CR, Wedin KE, Neeland IJ, Yuhanna IS, Rader DR, de Lemos JA, and Shaul PW: HDL cholesterol efflux capacity and incident cardiovascular events. N Engl J Med, 2014; 371: 2383-2393","DOI":"10.1056\/NEJMoa1409065"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Saleheen D, Scott R, Javad S, Zhao W, Rodrigues A, Picataggi A, Lukmanova D, Mucksavage ML, Luben R, Billheimer J, Kastelein JJ, Boekholdt SM, Khaw KT, Wareham N, Rader DJ: Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study. Lancet Diabetes Endocrinol, 2015; 3: 507-513","DOI":"10.1016\/S2213-8587(15)00126-6"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Ogura M, Hori M, Harada-Shiba M: Association Between Cholesterol Efflux Capacity and Atherosclerotic Cardiovascular Disease in Patients With Familial Hypercholesterolemia. Arterioscler Thromb Vasc Biol, 2016; 36: 181-188","DOI":"10.1161\/ATVBAHA.115.306665"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Brownell N, Rohatgi A: Modulating cholesterol efflux capacity to improve cardiovascular disease. Curr Opin Lipidol, 2016; 27: 398-407","DOI":"10.1097\/MOL.0000000000000317"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Rajkovic MG, Rumora L, Barisic K: The paraoxonase 1, 2 and 3 in humans. Biochem Med (Zagreb), 2011; 21: 122-130","DOI":"10.11613\/BM.2011.020"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Zhao Y, Ma Y, Fang Y, Liu L, Wu S, Fua D, Wang X: Association between PON1 activity and coronary heart disease risk: A meta-analysis based on 43 studies. Mol Genet Metab, 2012; 105: 141-148","DOI":"10.1016\/j.ymgme.2011.09.018"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Berrougui H, Loued S, Khalil A: Purified human paraoxonase-1 interacts with plasma membrane lipid rafts and mediates cholesterol efflux from macrophages. Free Radic Biol Med, 2012; 52: 1372-1381","DOI":"10.1016\/j.freeradbiomed.2012.01.019"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) The Japanese Circulation Society Joint Working Group: Guidelines for Rehabilitation in Patients with Cardiovascular Disease (JCS 2012) \u2013Digest Version\u2013. Circ J, 2014; 78: 2022-2093","DOI":"10.1253\/circj.CJ-66-0094"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Koba S, Ayaori M, Uto-Kondo H, Furuyama1 F, Yokota Y, Tsunoda F, Shoji M, Ikewaki K, Kobayashi Y: Benefi cial effects of exercise-based cardiac rehabilitation on high-density lipoprotein-mediated cholesterol efflux capacity in patients with acute coronary syndrome. J Atheroscler Thromb, 2016; 23: 865-877","DOI":"10.5551\/jat.34454"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Goldhammer E, Ben-Sira D, Zaid G, Biniamini Y, Maor I, Lanir A, Sagiv M: Paraoxonase activity following exercise-based cardiac rehabilitation program. J Cardiopulmonal Rehab Prev, 2007; 27: 151-154","DOI":"10.1097\/01.HCR.0000270691.09258.b1"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Beaver WL, Wasserman K, and Whipp BJ: A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol, 1986; 60: 2020-2027","DOI":"10.1152\/jappl.1986.60.6.2020"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K: Executive Summary of the Japan Atherosclerosis Society (JAS) Guidelines for the Diagnosis and Prevention of Atherosclerotic Cardiovascular Diseases in Japan -2012 Version. J Atheroscler Thromb, 2013; 20: 517-523","DOI":"10.5551\/jat.15792"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Imai E, Horio M, Watanabe T, Iseki K, Yamagata K, Hara S, Ura N, Kiyohara Y, Moriyama T, Ando Y, Fujimoto S, Konta T, Yokoyama H, Makino H, Hishida A, Matsuo S: Prevalence of chronic kidney disease in the Japanese general population. Clin Exp Nephrol, 2009; 13: 621-630","DOI":"10.1007\/s10157-009-0199-x"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014). Hypertens Res, 2014; 37: 253-392","DOI":"10.1038\/hr.2014.20"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Kashiwagi A, Kasuga M, Araki E, Oka Y, Hanafusa T, Ito H, Tominaga M, Oikawa S, Noda M, Kawamura T, Sanke T, Namba M, Hashiramoto M, Sasahara T, Nishio Y, Kuwa K, Ueki K, Takei I, Umemoto M, Murakami M, Yamakado M, Yatomi Y, Ohashi H, Committee on the Standardization of Diabetes Mellitus-Related Laboratory Testing of Japan Diabetes Society: International clinical harmonization of glycated hemoglobin in Japan: From Japan Diabetes Society to National Glycohemoglobin Standardization Program values. Diabetol Int, 2012; 3: 8-10","DOI":"10.1007\/s13340-012-0069-8"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Miida T, Nishimura K, Hirayama S, Miyamoto Y, Nakamura M, Masuda D, Yamashita S, Ushiyama M, Komori T, Fujita N, Yokoyama S, Teramoto T: Homogeneous Assays for LDL-C and HDL-C are Reliable in Both the Postprandial and Fasting State. J Atheroscler Thromb, 2017; 24: 583-599","DOI":"10.5551\/jat.40006"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Kotani K, Maekawa M, Kanno T, Kondo A, Toda N, Manabe M: Distribution of immunoreactive malondialdehyde-modified low-density lipoprotein in human serum. Biochim Biophys Acta, 1994; 1215: 121-125","DOI":"10.1016\/0005-2760(94)90100-7"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Nakajima K, Saito K, Tamura A, Suzuki M, Nakano T, Adachi M, Tanaka A, Tada N, Nakamura H, Campos E, and Havel RL: Cholesterol in remnant-like lipoproteins in human serum using monoclonal anti apoB-100 and anti apoA-1 immunoaffinity mixed gels. Clin Chim Acta, 1993; 223: 53-71","DOI":"10.1016\/0009-8981(93)90062-9"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Roberts WL, Moulton L, Law TC, Farrow G, Cooper-Anderson M, Savory J, Rifai N: Evaluation of nine automated high-sensitivity C-reactive protein methods: Implications for clinical and epidemiological applications. Part 2.Clin Chem, 2001; 47: 418-425","DOI":"10.1093\/clinchem\/47.3.418"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Yamashita S, Tsubakio-Yamamoto K, Ohama T, Nakagawa-Toyama Y, Nishida M: Molecular mechanisms of HDL-cholesterol elevation by statins and its effects on HDL functions. J Atheroscler Thromb, 2010; 17: 436-451","DOI":"10.5551\/jat.5405"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Casella-Filho A, Chagas AC, Maranh\u00e3o RC, Trombetta IC, Cesena FH, Silva VM, Tanus-Santos JE, Negr\u00e3o CE, da Luz PL: Effect of exercise training on plasma levels and functional properties of high-density lipoprotein cholesterol in the metabolic syndrome. Am J Cardiol, 2011; 107: 1168-1172","DOI":"10.1016\/j.amjcard.2010.12.014"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Ribeiro IC, Iborra RT, Neves MQ, Lottenberg SA, Charf AM, Nunes VS, Negr\u00e3o CE, Nakandakare ER, Quint\u00e3o EC, Passarelli M: HDL atheroprotection by aerobic exercise training in type 2 diabetes mellitus. Med Sci Sports Exerc, 2008; 40: 779-786","DOI":"10.1249\/MSS.0b013e3181632d2d"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Sang H, Yao S, Zhang L, Li X, Yang N, Zhao J, Zhao L, Si Y, Zhang Y, Lv X, Xue Y, Qin S: Walk-run training improves the anti-inflammation properties of high-density lipoprotein in patients with metabolic syndrome. J Clin Endocrinol Metab, 2015; 100: 870-879","DOI":"10.1210\/jc.2014-2979"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Aicher BO, Haser EK, Freeman LA, Carnie AV, Stonik JA, Wang X, Remaley AT, Kato GJ, Cannon RO 3rd: Diet-induced weight loss in overweight or obese women and changes in high-density lipoprotein levels and function. Obesity (Silver Spring), 2012; 20: 2057-2062","DOI":"10.1038\/oby.2012.56"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Kr\u00e1lov\u00e1 Lesn\u00e1 I, Such\u00e1nek P, Kov\u00e1r J, Poledne R: Life style change and reverse cholesterol transport in obese women. Physiol Res, 2009; 58 (Suppl 1): S33-S38","DOI":"10.33549\/physiolres.931856"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Liang KW, Lee WJ, Lee IT, Lee WL, Lin SY, Hsu SL, Wan CJ, Yu CY, Tsai IC, Fu CP, Ting CT, Sheu WH: Persistent elevation of paraoxonase-1 specific enzyme activity after weight reduction in obese non-diabetic men with metabolic syndrome. Clin Chim Acta, 2011; 412: 1835-1841","DOI":"10.1016\/j.cca.2011.06.018"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Roberts CK, Ng C, Hama S, Eliseo AJ, R. Barnard RJ: Effect of a short-term diet and exercise intervention on inflammatory\/anti-inflammatory properties of HDL in overweight\/obese men with cardiovascular risk factors. J Appl Physiol, 2006; 101: 1727-1732","DOI":"10.1152\/japplphysiol.00345.2006"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Kotani K, Caccavello R, Mutou T, Yamada T, Taniguchi N, Gugliucci A: Association between reactive oxygen metabolites and paraoxonase 1 activity during a physical activity increase intervention with older Japanese people. Australas J Ageing, 2012; 31: 222-226","DOI":"10.1111\/j.1741-6612.2011.00569.x"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Iborra RT, Ribeiro IC, Neves MQ, Charf AM, Lottenberg SA, Negr\u00e3o CE, Nakandakare ER, Passarelli M: Aerobic exercise training improves the role of high-density lipoprotein antioxidant and reduces plasma lipid peroxidation in type 2 diabetes mellitus. Scand J Med Sci Sports, 2008; 18: 742-750","DOI":"10.1111\/j.1600-0838.2007.00748.x"},{"key":"33","doi-asserted-by":"crossref","unstructured":"34) Olchawa B, Kingwell BA, Hoang A, Schneider L, Miyazaki O, Nestel P, Sviridov D: Physical Fitness and Reverse Cholesterol Transport. Arterioscler Thromb Vasc Biol, 2004; 24: 1087-1091","DOI":"10.1161\/01.ATV.0000128124.72935.0f"},{"key":"34","doi-asserted-by":"crossref","unstructured":"35) Brites F, Verona J, De Geitere C, Fruchart JC, Castro G, Wikinski R: Enhanced Cholesterol Efflux Promotion in Well-Trained Soccer Players. Metabolism, 2004; 53: 1262-1267","DOI":"10.1016\/j.metabol.2004.05.002"},{"key":"35","doi-asserted-by":"crossref","unstructured":"36) Senti M, Tom\u00e1s M, Anglada R, Elosua R, Marrugat J, Covas MI, Fit\u00f3 M: Interrelationship of smoking, paraoxonase activity, and leisure time physical activity: a population-based study. Eur J Intern Med, 2003; 14: 178-184","DOI":"10.1016\/S0953-6205(03)00041-4"},{"key":"36","doi-asserted-by":"crossref","unstructured":"37) Cakmak A, Zeyrek D, Atas A, Erel O: Paraoxonase activity in athletic adolescents. Pediatr Exerc Sci, 2010; 22: 93-104","DOI":"10.1123\/pes.22.1.93"},{"key":"37","doi-asserted-by":"crossref","unstructured":"38) Otocka-Kmiecik A, Lewandowski M, Szkudlarek U, Nowak D, Orlowska-Majdak M: Aerobic training modu lates the effects of exercise-induced oxidative stress on PON1 activity: a preliminary study. Scientific World Journal, 2014; 2014: 230271","DOI":"10.1155\/2014\/230271"},{"key":"38","doi-asserted-by":"crossref","unstructured":"39) Tom\u00e1s M, Elosua R, Sent\u00ed M, Molina L, Vila J, Anglada R, Fit\u00f3 M, Covas MI, Marrugat J: Paraoxonase1-192 polymorphism modulates the effects of regular and acute exercise on paraoxonase1 activity. J Lipid Res, 2002; 43: 713-720","DOI":"10.1016\/S0022-2275(20)30113-9"},{"key":"39","doi-asserted-by":"crossref","unstructured":"40) Sklan EH, Lowenthal A, Korner M, Ritov Y, Landers DM, Rankinen T, Bouchard C, Leon AS, Rice T, Rao DC, Wilmore JH, Skinner JS, Soreq H: Acetylcholinesterase\/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study. Proc Natl Acad Sci USA, 2004; 101: 5512-5517","DOI":"10.1073\/pnas.0307659101"},{"key":"40","doi-asserted-by":"crossref","unstructured":"42) Kontush A, Chapman: Functionally defective high-density lipoprotein: A new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis. Pharmacol Rev, 2006; 58: 342-374","DOI":"10.1124\/pr.58.3.1"},{"key":"41","doi-asserted-by":"crossref","unstructured":"43) Kameyama N, Maruyama C, Kotani K, Caccavello R, Gugliucci A, Matsui S, Araki R, Maruyama T: Postprandial Paraoxonase 1 activity following consumption of recommended amounts of mixed meals in healthy males. J Atheroscler Thromb, 2016; 23: 225-232","DOI":"10.5551\/jat.30585"},{"key":"42","doi-asserted-by":"crossref","unstructured":"44) Tang WHW, Hartiala J, Fan Y, Wu Y, Stewart AFR, Erdmann J, kathiresan S, The CARDIoGRAM Consortium, Roberts R, McPherson Allayee H, Hazen SL: Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk. Arterioscler Thromb Vasc Biol, 2012; 32: 2803-2812","DOI":"10.1161\/ATVBAHA.112.253930"},{"key":"43","doi-asserted-by":"crossref","unstructured":"45) Miyamoto-Sasaki M, Yasuda T, Monguchi T, Nakajima H, Mori K, Toh R, Ishida T, Hirata K: Pitavastatin increases HDL particles functionally preserved with cholesterol efflux capacity and antioxidative actions in dyslipidemic patients. J Atheroscle Thromb, 2013; 20: 708-716","DOI":"10.5551\/jat.17210"},{"key":"44","doi-asserted-by":"crossref","unstructured":"46) Ferretti G, Bacchetti T, Sahebkar A: effect of statin therapy on paraoxonase-1 status: A systematic review and meta-analysis of 25 clinical trials. Prog Lipid Res, 2015; 60: 50-73","DOI":"10.1016\/j.plipres.2015.08.003"},{"key":"45","doi-asserted-by":"crossref","unstructured":"47) Nicholls SJ, Ruotolo G, Brewer HB, Kane JP, Wang, Krueger KA, Adelman SJ, Nissen SE, Rader DJ: Cholesterol efflux capacity and pre-beta-1 HDL concentrations are increased in dyslipidemic patients treated with evacetrapib. J Am Coll Cardiol, 2015; 66: 2201-2210","DOI":"10.1016\/j.jacc.2015.09.013"},{"key":"46","doi-asserted-by":"crossref","unstructured":"48) Tanaka N, Ishida T, Nagao M, Mori T, Monguchi T, Sasaki M, Mori K, Kondo K, Nakajima H, Honjo T, Irino Y, Toh R, Shinohara M, Hirata K: Administration of high dose eicosapentaenoic acid enhances anti-inflammatory properties of high-density lipoprotein in Japanese patients with dyslipidemia. Atherosclerosis, 2014; 237: 577-583","DOI":"10.1016\/j.atherosclerosis.2014.10.011"},{"key":"47","doi-asserted-by":"crossref","unstructured":"49) Bounafaa A, Berrougui H, Ikhlef S, Essamadi A, Nasser B, Bennis A, Yamoul N, Ghalim N, Khalil A: Alteration of HDL functionality and PON1 activities in acute coronary syndromepatients. Clin Biochem, 2014; 47: 318-325","DOI":"10.1016\/j.clinbiochem.2014.09.001"},{"key":"48","doi-asserted-by":"crossref","unstructured":"50) Deakin SP, James RW: Genetic and environmental factors modulating serum concentrations and activities of the antioxidant enzyme paraoxonase\u20131. Clin Sci, 2004; 107: 435-447","DOI":"10.1042\/CS20040187"},{"key":"49","doi-asserted-by":"crossref","unstructured":"51) Rached F, Santos RD, Camont L, Miname MH, Lhomme M, Dauteuille C, Lecocq S, Serrano CV Jr, Chapman MJ, Kontush A: Defective functionality of HDL particles in familial apoA-I deficiency: relevance of alterations in HDL lipidome and proteome. J Lipid Res, 2014; 55: 2509-2520","DOI":"10.1194\/jlr.M051631"},{"key":"50","doi-asserted-by":"crossref","unstructured":"52) L\u00fcscher TF, Landmesser U, von Eckardstein A, Fogelman AM: High-density lipoprotein Vascular protective effects, dysfunction, and potential as therapeutic target. Circ Res, 2014; 114: 171-182","DOI":"10.1161\/CIRCRESAHA.114.300935"},{"key":"51","doi-asserted-by":"crossref","unstructured":"53) Ansell BJ, Watson KE, Fogelman AM, Navab M, Fonarow GC: High-density lipoprotein function Recent advances. J Am Coll Cardiol, 2005; 46: 1792-1798","DOI":"10.1016\/j.jacc.2005.06.080"}],"container-title":["Journal of Atherosclerosis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/25\/2\/25_41095\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T22:51:39Z","timestamp":1659394299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/25\/2\/25_41095\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.5551\/jat.41095","relation":{},"ISSN":["1340-3478","1880-3873"],"issn-type":[{"value":"1340-3478","type":"print"},{"value":"1880-3873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}