{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:34:40Z","timestamp":1790231680185,"version":"4.1.0"},"reference-count":23,"publisher":"Japan Atherosclerosis Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Atheroscler Thromb","JAT"],"published-print":{"date-parts":[[2018,8,1]]},"DOI":"10.5551\/jat.41996","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T22:10:19Z","timestamp":1517523019000},"page":"733-740","source":"Crossref","is-referenced-by-count":23,"title":["The Novel Apolipoprotein E Mutation ApoE Chengdu (c.518T\uff1eC, p.L173P) in a Chinese Patient with Lipoprotein Glomerulopathy"],"prefix":"10.5551","volume":"25","author":[{"given":"Hongyan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Nephrology, West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangxue","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3489","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Hu Z, Huang S, Wu Y, Liu Y, Liu X, Su D, Tao Y, Fu P, Zhang X, Peng Z, Zhang S and Yang Y: Hereditary features, treatment, and prognosis of the lipoprotein glomerulopathy in patients with the APOE Kyoto mutation. Kidney Int, 2014; 85: 416-424","DOI":"10.1038\/ki.2013.335"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Saito T, Matsunaga A and Oikawa S: Impact of lipoprotein glomerulopathy on the relationship between lipids and renal diseases. Am J Kidney Dis, 2006; 47: 199-211","DOI":"10.1053\/j.ajkd.2005.10.017"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Saito T, Sato H, Kudo K, Oikawa S, Shibata T, Hara Y, Yoshinaga K and Sakaguchi H: Lipoprotein glomerulopathy: glomerular lipoprotein thrombi in a patient with hyperlipoproteinemia. Am J Kidney Dis, 1989; 13: 148-153","DOI":"10.1016\/S0272-6386(89)80134-9"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Oikawa S, Matsunaga A, Saito T, Sato H, Seki T, Hoshi K, Hayasaka K, Kotake H, Midorikawa H, Sekikawa A, Hara S, Abe K, Toyota T, Jingami H, Nakamura H and Sasaki J: Apolipoprotein E Sendai (arginine 145--&gt;proline): a new variant associated with lipoprotein glomerulopathy. J Am Soc Nephrol, 1997; 8: 820-823","DOI":"10.1681\/ASN.V85820"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Matsunaga A, Sasaki J, Komatsu T, Kanatsu K, Tsuji E, Moriyama K, Koga T, Arakawa K, Oikawa S, Saito T, Kita T and Doi T: A novel apolipoprotein E mutation, E2 (Arg25Cys), in lipoprotein glomerulopathy. Kidney Int, 1999; 56: 421-427","DOI":"10.1046\/j.1523-1755.1999.00572.x"},{"key":"6","unstructured":"6) Zhang B, Liu ZH, Zeng CH, Zheng JM, Chen HP and Li LS: Clinicopathological and genetic characteristics in Chinese patients with lipoprotein glomerulopathy. J Nephrol, 2008; 21: 110-117"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Zhong L, Xie YZ, Cao TT, Wang Z, Wang T, Li X, Shen RC, Xu H, Bu G and Chen XF: A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism. Mol Neurodegener, 2016; 11: 2","DOI":"10.1186\/s13024-016-0069-4"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Rall SC, Jr., Weisgraber KH and Mahley RW: Human apolipoprotein E. The complete amino acid sequence. The Journal of biological chemistry, 1982; 257: 4171-4178","DOI":"10.1016\/S0021-9258(18)34702-1"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Hoffmann M, Scharnagl H, Panagiotou E, Banghard W, Wieland H and Marz W: Diminished LDL receptor and high heparin binding of apolipoprotein E2 Sendai associated with lipoprotein glomerulopathy. J Am Soc Nephrol, 2001; 12: 524-530","DOI":"10.1681\/ASN.V123524"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Saito T, Matsunaga A, Ito K and Nakashima H: Topics in lipoprotein glomerulopathy: an overview. Clin Exp Nephrol, 2014; 18: 214-217","DOI":"10.1007\/s10157-013-0887-4"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Sam R, Wu H, Yue L, Mazzone T, Schwartz MM, Arruda JA, Dunea G and Singh AK: Lipoprotein glomerulopathy: a new apolipoprotein E mutation with enhanced glomerular binding. Am J Kidney Dis, 2006; 47: 539-548","DOI":"10.1053\/j.ajkd.2005.12.031"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Luo B, Huang F, Liu Q, Li X, Chen W, Zhou SF and Yu X: Identification of apolipoprotein E Guangzhou (arginine 150 proline), a new variant associated with lipoprotein glomerulopathy. Am J Nephrol, 2008; 28: 347-353","DOI":"10.1159\/000111828"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Tokura T, Itano S, Kobayashi S, Kuwabara A, Fujimoto S, Horike H, Satoh M, Komai N, Tomita N, Matsunaga A, Saito T, Sasaki T and Kashihara N: A novel mutation ApoE2 Kurashiki (R158P) in a patient with lipoprotein glomerulopathy. J Atheroscler Thromb, 2011; 18: 536-541","DOI":"10.5551\/jat.8102"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Mitani A, Ishigami M, Watase K, Minakata T and Yamamura T: A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulopathy. J Atheroscler Thromb, 2011; 18: 531-535","DOI":"10.5551\/jat.7377"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Georgiadou D, Stamatakis K, Efthimiadou EK, Kordas G, Gantz D, Chroni A and Stratikos E: Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy. J Lipid Res, 2013; 54: 164-176","DOI":"10.1194\/jlr.M030965"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Ishigaki Y, Oikawa S, Suzuki T, Usui S, Magoori K, Kim DH, Suzuki H, Sasaki J, Sasano H, Okazaki M, Toyota T, Saito T and Yamamoto TT: Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice. The Journal of biological chemistry, 2000; 275: 31269-31273","DOI":"10.1074\/jbc.M005906200"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Hagiwara M, Yamagata K, Matsunaga T, Arakawa Y, Usui J, Shimizu Y, Aita K, Nagata M, Koyama A, Zhang B, Mastunaga A, Saku K and Saito T: A novel apolipoprotein E mutation, ApoE Tsukuba (Arg 114 Cys), in lipoprotein glomerulopathy. Nephrol Dial Transplant, 2008; 23: 381-384","DOI":"10.1093\/ndt\/gfm735"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Konishi K, Saruta T, Kuramochi S, Oikawa S, Saito T, Han H, Matsunaga A and Sasaki J: Association of a novel 3-amino acid deletion mutation of apolipoprotein E (ApoE Tokyo) with lipoprotein glomerulopathy. Nephron, 1999; 83: 214-218","DOI":"10.1159\/000045513"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Saito T, Sato H, Oikawa S, Kudo K, Kurihara I, Nakayama K, Abe K, Yoshinaga K and Sakaguchi H: Lipoprotein glomerulopathy. Report of a normolipidemic case and review of the literature. Am J Nephrol, 1993; 13: 64-68","DOI":"10.1159\/000168591"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Murano T, Matsumura R, Misawa Y, Ozaki H, Miyashita Y, Yoshida S, Sueioshi M, Sugiyama T and Shirai K: Interaction of endothelial cells and triglyceride-rich lipoproteins with apolipoprotein E (Arg--&gt;Cys) from a patient with lipoprotein glomerulopathy. Metabolism, 2002; 51: 201-205","DOI":"10.1053\/meta.2002.29990"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Matsunaga A, Furuyama M, Hashimoto T, Toyoda K, Ogino D and Hayasaka K: Improvement of nephrotic syndrome by intensive lipid-lowering therapy in a patient with lipoprotein glomerulopathy. Clin Exp Nephrol, 2009; 13: 659-662","DOI":"10.1007\/s10157-009-0207-1"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Kinomura M, Sugiyama H, Saito T, Matsunaga A, Sada K-e, Kanzaki M, Takazawa Y, Maeshima Y, Yanai H and Makino H: A novel variant apolipoprotein E Okayama in a patient with lipoprotein glomerulopathy. Nephrol Dial Transplant, 2008; 23: 751-756","DOI":"10.1093\/ndt\/gfm675"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Arai T, Yamashita S, Yamane M, Manabe N, Matsuzaki T, Kiriyama K, Kanayama Y, Himeno S and Matsuzawa Y: Disappearance of intraglomerular lipoprotein thrombi and marked improvement of nephrotic syndrome by bezafibrate treatment in a patient with lipoprotein glomerulopathy. Atherosclerosis, 2003; 169: 293-299","DOI":"10.1016\/S0021-9150(03)00194-1"}],"container-title":["Journal of Atherosclerosis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/25\/8\/25_41996\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T19:54:47Z","timestamp":1660420487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/25\/8\/25_41996\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,1]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.5551\/jat.41996","relation":{},"ISSN":["1340-3478","1880-3873"],"issn-type":[{"value":"1340-3478","type":"print"},{"value":"1880-3873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,1]]}}}