{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:22:05Z","timestamp":1792657325450,"version":"4.5.0"},"reference-count":47,"publisher":"Japan Atherosclerosis Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Atheroscler Thromb","JAT"],"published-print":{"date-parts":[[2018,4,1]]},"DOI":"10.5551\/jat.42010","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T17:08:37Z","timestamp":1513012117000},"page":"308-322","source":"Crossref","is-referenced-by-count":152,"title":["Rationale and Descriptive Analysis of Specific Health Guidance: the Nationwide Lifestyle Intervention Program Targeting Metabolic Syndrome in Japan"],"prefix":"10.5551","volume":"25","author":[{"given":"Kazuyo","family":"Tsushita","sequence":"first","affiliation":[{"name":"Comprehensive Health Science Center, Aichi Health Promotion Public Interest Foundation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko S","family":"Hosler","sequence":"additional","affiliation":[{"name":"University at Albany (SUNY) School of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Miura","sequence":"additional","affiliation":[{"name":"Shiga University of Medical Science"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Tokyo Gakugei University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"National Institute of Public Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Institute of Gerontology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Tatara","sequence":"additional","affiliation":[{"name":"Japan Public Health Association"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3489","reference":[{"key":"1","unstructured":"1) OECD Data: Life Expectancy at Birth. Organization for Economic Co-operation and Development, Paris. https:\/\/ data.oecd.org\/healthstat\/life-expectancy-at-birth.htm"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Ikeda N, Saito E, Kondo N, Inoue M, Ikeda S, Satoh T, Wada K, Stickley A, Katanoda K, Mizoue T, Noda M, Iso H, Fujino Y, Sobue T, Tsugane S, Naghavi M, Ezzati M, Shibuya K. What has made the population of Japan healthy? Lancet 2011; 378: 1094-1105","DOI":"10.1016\/S0140-6736(11)61055-6"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Johansson SR, Mosk C. Exposure, resistance and life expectancy: disease and death during the economic development of Japan, 1900-1960. Pupul Stud (Camb) 1987; 41: 207-235","DOI":"10.1080\/0032472031000142776"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Tatara K, Shinsho F, Suzuki, M, Takatorige T, Nakanishi N, Kuroda K. Relation between use of health checkups starting in middle age and demand for inpatient care by elderly people in Japan. BMJ 1991; 302: 615-618","DOI":"10.1136\/bmj.302.6777.615"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Ikegami N, Yoo BK, Hashimoto H, Matsumoto M, Ogata H, Babazono A, Watanabe R, Shibuya K, Yang BM, Reich MR, Kobayashi Y. Japanese universal health coverage: evolution, achievements, and challenges. Lancet 2011; 378: 1106-1115","DOI":"10.1016\/S0140-6736(11)60828-3"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Ueshima H, Tatara K, Asakura S, Okamoto M. Declining trends in blood pressure level and the prevalence of hyper tension, and changes in related factors in Japan, 1956\u20131980. J Chronic Dis 1987; 40: 137-147","DOI":"10.1016\/0021-9681(87)90065-8"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Iso H, Shimamoto T, Naito Y, Kitamura A, Iida M, Konishi M, Jacobs DR Jr, Komachi Y. Effects of a long-term hypertension control program on stroke incidence and prevalence in a rural community in northeastern Japan. Stroke 1998; 29: 1510-1518","DOI":"10.1161\/01.STR.29.8.1510"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Ikeda N, Gakidou E, Hasegawa T, Murray CJ. Understanding the decline of mean systolic blood pressure in Japan: an analysis of pooled data from the National Nutrition Survey, 1986\u20132002. Bull World Health Organ 2008; 86: 978-988","DOI":"10.2471\/BLT.07.050195"},{"key":"9","unstructured":"9) Statistics Bureau, Ministry of Internal Affaits and Communications. Population of Japan: Final Report of the 2005 Poulation Census. Tokyo: Japan Statistiocal Association, 2010 (in Japanese)"},{"key":"10","unstructured":"10) OECD Data: Health Spending. Organization for Economic Co-operation and Development, Paris. https:\/\/data. oecd.org\/healthres\/health-spending.htm"},{"key":"11","unstructured":"11) OECD. OECD Health Statistics 2014: How does Japan compare? Organization for Economic Co-operation and Development. http:\/\/www.oecd.org\/els\/health-systems\/Briefing-Note-JAPAN-2014.pdf"},{"key":"12","unstructured":"12) Udagawa K, Miyoshi M, Yoshiike N. Mid-term evaluation of \u201cHealth Japan 21\u201d: focus area for the nutrition and diet. Asia Pac J Clin Nutr 2008; 17 Suppl 2: 445-452"},{"key":"13","unstructured":"13) OECD Data: Overweight or obese population. Organization for Economic Co-operation and Development. https:\/\/ data.oecd.org\/healthrisk\/overweight-or-obese-population. htm"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Sakane N, Yoshida T, Umekawa, T, Kondo M, Sakai Y, Takahashi T. Beta 3-adrenergic-receptor polymorphism: a genetic marker for visceral fat obesity and the insulin resistance syndrome. Diabetologia 1997; 40: 200-204","DOI":"10.1007\/s001250050663"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Rakugi H, Ogihara T. The metabolic syndrome in the Asian population. Curr Hypertens Rep 2005; 7: 103-109","DOI":"10.1007\/s11906-005-0082-4"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Ahuja V, Kadowaki T, Evans RW, Kadota A, Okamura T, El Khoudary SR, Fujiyoshi A, Barinas-Mitchell EJ, Hisamatsu T, Vishnu A, Miura K, Maegawa H, El-Saed A, Kashi wagi A, Kuller LH, Ueshima H, Sekikawa A; ERA JUMP Study Group. Comparison of HOMA-IR, HOMA-\u03b2% and disposition index between US white men and Japanese men in Japan: the ERA JUMP study. Diabetologia 2015; 58: 265-271","DOI":"10.1007\/s00125-014-3414-6"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Matsuzawa Y, Funahashi T, Nakamura T. The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism. J Atheroscler Thromb. 2011; 18: 629-639","DOI":"10.5551\/jat.7922"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Hirose H, Takayama M, Iwao Y, Kawabe H. Effects of Aging on Visceral and Subcutaneous Fat Areas and on Homeostasis Model Assessment of Insulin Resistance and Insulin Secretion Capacity in a Comprehensive Health Checkup. J Atheroscler Thromb. 2016; 23: 207-215","DOI":"10.5551\/jat.30700"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Matsuzawa Y. Metabolic syndrome-definition and diagnostic criteria in Japan. J JPN Soc Int Med 2005; 94: 188-203","DOI":"10.5551\/jat.12.301"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Committee for Epidemiology and Clinical Management of Atherosclerosis. Metabolic syndrome. J Atheroscler Thromb 2008; 15: 1-5","DOI":"10.5551\/jat.E580"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-2497","DOI":"10.1001\/jama.285.19.2486"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr; International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; International Association for the Study of Obesity. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009; 120: 1640-1645","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Despr\u00e9s JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006; 444: 881-887","DOI":"10.1038\/nature05488"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Ouchi N. Adipocytokines in Cardiovascular and Metabolic Diseases. J Atheroscler Thromb. 2016; 23: 645-654","DOI":"10.5551\/jat.34918"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Funahashi T, Matsuzawa Y. Metabolic syndrome: clinical concept and molecular basis. Ann Med 2007; 39: 482-494","DOI":"10.1080\/07853890701491026"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403","DOI":"10.1056\/NEJMoa012512"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, H\u00e4m\u00e4l\u00e4inen H, Ilanne-Parikka P, Kein\u00e4nen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa Finnish Diabetes Prevention Study Group. M. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001; 344: 1343-1350","DOI":"10.1056\/NEJM200105033441801"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Eriksson KF, Lindg\u00e4rde F. Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. The 6-year Malm\u00f6 feasibility study. Diabetologia 1991; 34: 891-898","DOI":"10.1007\/BF00400196"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Sakane N, Sato J, Tsushita K, Tsujii S, Kotani K, Tsuzaki K, Tominaga M, Kawazu S, Sato Y, Usui T, Kamae I, Yoshida T, Kiyohara Y, Sato S, Kuzuya H; Japan Diabetes Prevention Program (JDPP) Research Group.l. Prevention of type 2 diabetes in a primary healthcare setting: three year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance. BMC Public Health. 2011; 11: 40-47","DOI":"10.1186\/1471-2458-11-40"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Kohro T, Furui Y, Mitsutake N, Fujii R, Morita H, Oku S, Ohe K, Nagai R. The Japanese national health screening and intervention program aimed at preventing worsening of the metabolic syndrome. Int Heart J 2008; 49: 193-203","DOI":"10.1536\/ihj.49.193"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Mizushima S, Tsushita K. New strategy on prevention and control of noncommunicable lifestyle-related diseases focusing on metabolic syndrome in Japan. Pp.31-39. In Muto T, Nam EW, Nakahara T. Asian Perspectives and Evidence on Health Promotion and Education. Tokyo; Springer Japan, 2011","DOI":"10.1007\/978-4-431-53889-9_4"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Nagasawa Y, Yamamoto R, Shinzawa M, Hasuike Y, Kuragano T, Isaka Y, Nakanishi T, Iseki K, Yamagata K, Tsuruya K, Yoshida H, Fujimoto S, Asahi K, Moriyama T, Watanabe T. Body Mass Index Modifies an Association between Self-Reported Regular Exercise and Proteinuria, A nationwide Cross-Sectional Survey in Japan. J Atheroscler Thromb. 2016; 23: 402-412","DOI":"10.5551\/jat.29009"},{"key":"33","unstructured":"33) Ministry of Health, Labour and Welfare. Operational Guide to Specific Health Checkups and Specific Health Guidance (2013 Edition, in Japanese), Ministry of Health, Labour and Welfare, Tokyo, Japan. http:\/\/www.mhlw.go. jp\/bunya\/shakaihosho\/iryouseido01\/pdf\/info03d-1.pdf"},{"key":"34","doi-asserted-by":"publisher","unstructured":"34) Muramoto A, Tsushita K, Kato A, Ozaki N, Tabata M, Endo M, Oike Y, Oiso Y. Angiopoietin-like protein 2 sensitively responds to weight reduction induced by lifestyle intervention on overweight Japanese men. Nutr Diabetes 2011, Nov 7; 1: e20. doi: 10.1038\/nutd.2011.16","DOI":"10.1038\/nutd.2011.16"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Muramoto A, Matsushita M, Kato A, Yamamoto N Koike G, Nakamura M, Numata T, Tamakoshi A, Tsushita K. Three percent weight reduction is the minimum requirement to improve health hazards in obese and overweight people in Japan. Obes Res Clin Pract 2014; 8: e466-475","DOI":"10.1016\/j.orcp.2013.10.003"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Gregg EW, Ali MK, Moore BA, Pavkov M, Devlin HM, Garfield S, Mangione CM. The importance of natural experiments in diabetes prevention and control and the need for better health policy research. Prev Chronic Dis 2013; 10: 120-145","DOI":"10.5888\/pcd10.120145"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Jackson SL. Long Q, Rhee MK, Olson DE, Tomolo AM, Cunningham SA, Ramakrishnan U, Narayan KM, Phillips LS. Weight loss and incidence of diabetes with the Veterans Health Administration MOVE! lifestyle change programme: an observational study. Lancet Diabetes Endocrionol 2015; 3: 173-180","DOI":"10.1016\/S2213-8587(14)70267-0"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Dunkley AJ, Bodicoat DH, Greaves CJ, Russell C, Yates T, Davies MJ, Khunti K. Diabetes prevention in the real world: effectiveness of pragmatic lifestyle interventions for the prevention of type 2 diabetes amd of the impact of adherence to guidelines recommendations. A systematic review and meta-analysis. Diabetes Care 2014; 37: 922- 933","DOI":"10.2337\/dc13-2195"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Mudaliar U, Zabetian A, Goodman M, Echouffo-Tcheugui JB, Albright AL, Gregg EW, Ali MK. Cardiometabolic risk factor changes observed in diabetes prevention programs in US settings: a systematic review and meta-analy sis.PLOS Med 13(7): e1002095, doi: 10.1371","DOI":"10.1371\/journal.pmed.1002095"},{"key":"40","unstructured":"40) Lin JS, O&apos;Connor EA, Evans CV, Senger CA, Rowland MG, Groom HC. Behavioral counseling to promote a healthy lifestyle for cardiovascular disease prevention in persons with cardiovascular risk factors: an updated systematic evidence review for the U.S. Preventive Services Task Force. AHRQ Publication No. 13-05179-EF-1, 2014. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK241537\/pdf\/Bookshelf_NBK241537.pdf"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Albright AL, Gregg EW. Preventing Type 2 diabetes in communities across the U.S.: the National Diabetes Prevention Program. Am J Prev Med 2013; 44: S346-351","DOI":"10.1016\/j.amepre.2012.12.009"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Nishi N. Monitoring obesity trends in Health Japan 21. J Nutr Sci Vitaminol (Tokyo). 2015; 61 Suppl: S17-19","DOI":"10.3177\/jnsv.61.S17"},{"key":"43","unstructured":"43) Nakamura T. Nutritional Policies and dietary guideline in Japan. Asia Pac J Clin Nutr 2011; 20: 452-454"},{"key":"44","unstructured":"44) Tsushita K. Practice and evaluation of lifestyle intervention program. Internal Medicine (Japanese). 2016; 105: 1654-1661"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Hayashi K, Takayama M, Abe T, Kanda T, Hirose H, Shimizu-Hirota R, Shiomi E, Iwao Y, Itoh H. Investigation of Metabolic Factors Associated with eGFR Decline Over 1 Year in a Japanese Population without CKD. J Atheroscler Thromb. 2017; 24: 863-875","DOI":"10.5551\/jat.38612"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Kikui M, Kokubo Y, Ono T, Kida M, Kosaka T, Yamamoto M, Watanabe M, Maeda Y, Miyamoto Y. Relation-ship between Metabolic Syndrome Components and Periodontal Disease in a Japanese General Population: the Suita Study. J Atheroscler Thromb. 2017; 24: 495-507","DOI":"10.5551\/jat.33761"},{"key":"47","unstructured":"47) United Nations General Assembly Sixty-sixth session. Agenda item 117. Follow-up to the outcome of the Millennium Summit. Draft resolution submitted by the President of the General Assembly. Political declaration of the High-level Meeting of the General Assembly on the Prevention and Control of Non-communicable Diseases. https:\/\/ncdalliance.org\/sites\/default\/files\/resource_files\/UN%20Political%20Declaration%20on%20NCDs.pdf"}],"container-title":["Journal of Atherosclerosis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/25\/4\/25_42010\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T17:28:17Z","timestamp":1570469297000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/25\/4\/25_42010\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,1]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.5551\/jat.42010","relation":{},"ISSN":["1340-3478","1880-3873"],"issn-type":[{"value":"1340-3478","type":"print"},{"value":"1880-3873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,1]]}}}