{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T08:41:03Z","timestamp":1770453663964,"version":"3.49.0"},"reference-count":55,"publisher":"Japan Atherosclerosis Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Atheroscler Thromb","JAT"],"published-print":{"date-parts":[[2019,3,1]]},"DOI":"10.5551\/jat.45294","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T22:29:34Z","timestamp":1533680974000},"page":"260-271","source":"Crossref","is-referenced-by-count":22,"title":["Carotid Intima-Media Thickness in Patients with Ankylosing Spondylitis: A Systematic Review and Updated Meta-Analysis"],"prefix":"10.5551","volume":"26","author":[{"given":"Yaping","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University"},{"name":"The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajia","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University"},{"name":"The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University"},{"name":"The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renfang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University"},{"name":"The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengya","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University"},{"name":"The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingxing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University"},{"name":"The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubo","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University"},{"name":"The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University"},{"name":"The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengmeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University"},{"name":"The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengqian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faming","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University"},{"name":"The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3489","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Dubreuil M, Peloquin C, and Zhang Y: Validity of ankylosing spondylitis diagnoses in The Health Improvement Network. Pharmacoepidemiol Drug Saf, 2016; 25: 399-404","DOI":"10.1002\/pds.3952"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Szabo SM, Levy AR, and Rao SR: Increased risk of cardiovascular and cerebrovascular diseases in individuals with ankylosing spondylitis: a population-based study. Ann Rheum Dis, 2011; 63: 3294-3304","DOI":"10.1002\/art.30581"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Lehtinen K: Mortality and causes of death in 398 patients admitted to hospital with ankylosing spondylitis. Ann Rheum Dis, 1993; 52: 174-176","DOI":"10.1136\/ard.52.3.174"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Liu YL, Skklo M, and Davidson KW: Differential Association of Psychosocial Comorbidities with Subclinical Atherosclerosis in Rheumatoid Arthritis. Arthritis Care Res (Hoboken), 2015; 67: 1335-1344","DOI":"10.1002\/acr.22635"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Katakami N, Kaneto H, and Shimomura I: Carotid ultrasonography: A potent tool for better clinical practice in diagnosis of atherosclerosis in diabetic patients. J Diabetes Investig, 2014; 5: 3-13","DOI":"10.1111\/jdi.12106"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Chambless LE, Heiss G, and Folsom AR: Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993. Am J Epidemiol, 1997; 146: 483-494","DOI":"10.1093\/oxfordjournals.aje.a009302"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) O'Leary DH, Polak JF: Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med, 1999; 340: 14-22","DOI":"10.1056\/NEJM199901073400103"},{"key":"8","unstructured":"8) Papagoras C, Voulgari PV, and Drosos AA: Atherosclerosis and cardiovascular disease in the spondyloarthritides, particularly ankylosing spondylitis and psoriatic arthritis. Clin Exp Rheumatol, 2013; 31: 612-620"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Azevedo VF, Pecoits-Filho R: Atherosclerosis and endothelial dysfunction in patients with ankylosing spondylitis. Rheumatol Int, 2010; 30: 1411-1416","DOI":"10.1007\/s00296-010-1416-3"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Yusuf S, Hawken S, and Ounpuu S: Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): casecontrol study. Lancet, 2004; 364: 937-952","DOI":"10.1016\/S0140-6736(04)17018-9"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Frostegard J: Immunity, atherosclerosis and cardiovascular disease. BMC med, 2013; 11: 117","DOI":"10.1186\/1741-7015-11-117"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Pant S, Deshmukh A, and Gurumurthy: Inflammation and atherosclerosis--revisited. J Cardiovasc Pharmacol Ther, 2014; 19: 170-178","DOI":"10.1177\/1074248413504994"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Van Sijl AM, Van Eijk IC, and Peters MJ: Tumour necrosis factor blocking agents and progression of subclinical atherosclerosis in patients with ankylosing spondylitis. Ann Rheum Dis, 2015; 74: 119","DOI":"10.1136\/annrheumdis-2013-203934"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Verma I, Krishan P, and Syngle A: Predictors of Atherosclerosis in Ankylosing Spondylitis. Rheumatol Ther, 2015; 2: 173-182","DOI":"10.1007\/s40744-015-0017-8"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Ustun N, Kurt M, and Atci N: Increased Epicardial Fat Tissue Is a Marker of Subclinic Atherosclerosis in Ankylosing Spondylitis. Archives of Rheumatology, 2014; 29: 267-272","DOI":"10.5606\/ArchRheumatol.2014.4606"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Choe JY, Lee MY, and Rheem I: No differences of carotid intima-media thickness between young patients with ankylosing spondylitis and healthy controls. Joint Bone Spine, 2008; 75: 548-553","DOI":"10.1016\/j.jbspin.2007.11.007"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Gecene M, Tuncay F, and Borman P: Atherosclerosis in male patients with ankylosing spondylitis: the relation with methylenetetrahydrofolate reductase (C677T) gene polymorphism and plasma homocysteine levels. Rheumatol Int, 2013; 33: 1519-1524","DOI":"10.1007\/s00296-012-2552-8"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Mathieu S, Joly H, and Baron G: Trend towards increased arterial stiffness or intima-media thickness in ankylosing spondylitis patients without clinically evident cardiovascular disease. Rheumatology (Oxford, England), 2008; 47: 1203-1207","DOI":"10.1093\/rheumatology\/ken198"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Arida A, Protogerou AD, and Konstantonis G: Subclinical Atherosclerosis Is Not Accelerated in Patients with Ankylosing Spondylitis with Low Disease Activity: New Data and Metaanalysis of Published Studies. J Rheumatol, 2015; 42: 2098-2105","DOI":"10.3899\/jrheum.150316"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Stang, A: Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J epidemiol, 2010; 25: 603-605","DOI":"10.1007\/s10654-010-9491-z"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Wan X, Wang W, and Liu J: Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med Res Methodol, 2014; 14: 135","DOI":"10.1186\/1471-2288-14-135"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Verma I, Syngle A, and Krishan P: Endothelial Progenitor Cells as a Marker of Endothelial Dysfunction and Atherosclerosis in Ankylosing Spondylitis: A Cross-Sectional Study. Int J Angiol, 2017; 26: 36-42","DOI":"10.1055\/s-0036-1593445"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Kucuk A, Ugur Uslu A, and Icli A: The LDL\/HDL ratio and atherosclerosis in ankylosing spondylitis. Z Rheumatol, 2017; 76: 58-63","DOI":"10.1007\/s00393-016-0092-4"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Malesci D, Niglio A, and Mennillo GA: High prevalence of metabolic syndrome in patients with ankylosing spondylitis. Clin Rheumatol, 2007; 26: 710-714","DOI":"10.1007\/s10067-006-0380-5"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Erre GL, Sanna P, and Zinellu A: Plasma asymmetric dimethylarginine (ADMA) levels and atherosclerotic disease in ankylosing spondylitis: a cross-sectional study. Clin Rheumatol, 2011; 30: 21-27","DOI":"10.1007\/s10067-010-1589-x"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Resorlu H, Akbal A, and Resorlu: Epicardial adipose tissue thickness in patients with ankylosing spondylitis. Clin Rheumatol, 2015; 34: 295-299","DOI":"10.1007\/s10067-014-2568-4"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Beyazal MS, Erdogan T, and Turkyilmaz AK: Relationship of serum osteoprotegerin with arterial stiffness, preclinical atherosclerosis, and disease activity in patients with ankylosing spondylitis. Clin Rheumatol, 2016; 35: 2235-2241","DOI":"10.1007\/s10067-016-3198-9"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Cure E, Icli A, and Uslu AU: Atherogenic index of plasma: a useful marker for subclinical atherosclerosis in ankylosing spondylitis: AIP associate with cIMT in AS. Clin Rheumatol, 2018;","DOI":"10.1007\/s10067-018-4027-0"},{"key":"29","unstructured":"29) Kucukali Turkyilmaz A, Devrimsel G, and Serdaroglu Beyazal: The relationship between serum YKL-40 levels and arterial stiffness in patients with ankylosing spondylitis. Acta Reumatol Port, 2017; 42: 183-190"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Hamdi W, Bouaziz MC, and Zouch I: Assessment of Preclinical Atherosclerosis in Patients with Ankylosing Spondylitis. J Rheumatol, 2012; 39: 322-326","DOI":"10.3899\/jrheum.110792"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Bodnar N, Kerekes G, and Seres I: Assessment of subclinical vascular disease associated with ankylosing spondylitis. J Rheumatol, 2011; 38: 723-729","DOI":"10.3899\/jrheum.100668"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Gupta N, Saigal R, and Goyal L: Carotid intima media thickness as a marker of atherosclerosis in ankylosing spondylitis. Int J Rheumatol, 2014; 2014: 839135","DOI":"10.1155\/2014\/839135"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Sari I, Okan T, and Akar S: Impaired endothelial function in patients with ankylosing spondylitis. Rheumatology (Oxford, England), 2006; 45: 283-286","DOI":"10.1093\/rheumatology\/kei145"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Peters MJ, van Eijk IC, and Smulders YM: Signs of accelerated preclinical atherosclerosis in patients with ankylosing spondylitis. J Rheumatol, 2010; 37: 161-166","DOI":"10.3899\/jrheum.090667"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Ercan S, Goktepe F, and Kisacik B: Subclinical cardiovascular target organ damage manifestations of ankylosing spondylitis in young adult patients. Mod Rheumatol, 2013; 23: 1063-1068","DOI":"10.3109\/s10165-012-0791-x"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Gonzalez-Juanatey C, Vazquez-Rodriguez TR, and Miranda-Filloy JA: The high prevalence of subclinical atherosclerosis in patients with ankylosing spondylitis without clinically evident cardiovascular disease. Medicine (Baltimore), 2009; 88: 358-365","DOI":"10.1097\/MD.0b013e3181c10773"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Stanek A, Cholewka A, and Wielkoszynski T: Increased Levels of Oxidative Stress Markers, Soluble CD40 Ligand, and Carotid Intima-Media Thickness Reflect Acceleration of Atherosclerosis in Male Patients with Ankylosing Spondylitis in Active Phase and without the Classical Cardiovascular Risk Factors. Oxid Med Cell Longev, 2017; 2017: 9712536","DOI":"10.1155\/2017\/9712536"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Cece H, Yazgan P, and Karakas E: Carotid intima-media thickness and paraoxonase activity in patients with ankylosing spondylitis. Clin Invest Med, 2011; 34: E225-E231","DOI":"10.25011\/cim.v34i4.15364"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Perrotta FM, Scarno A, and Carboni A: Assessment of subclinical atherosclerosis in ankylosing spondylitis: correlations with disease activity indices. Reumatismo, 2013; 65: 105-112","DOI":"10.4081\/reumatismo.2013.105"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Capkin E, Kiris A and Karkucak M: Investigation of effects of different treatment modalities on structural and functional vessel wall properties in patients with ankylosing spondylitis. Joint Bone Spine, 2011; 78: 378-382","DOI":"10.1016\/j.jbspin.2010.09.023"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Zoller B, Li X, and Sundquist J: Risk of subsequent ischemic and hemorrhagic stroke in patients hospitalized for immune-mediated diseases: a nationwide follow-up study from Sweden. BMC Neurol, 2012; 12: 41","DOI":"10.1186\/1471-2377-12-41"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) John H, Kitas G: Inflammatory arthritis as a novel risk factor for cardiovascular disease. Eur J Intern Med, 2012; 23: 575-579","DOI":"10.1016\/j.ejim.2012.06.016"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Katakami N, Mita T, and Gosho M: Clinical Utility of Carotid Ultrasonography in The Prediction of Cardiovascular Events in Patients with Diabetes: A Combined Analysis of Data Obtained in Five Longitudinal Studies. J Atheroscler Thromb, 2018;","DOI":"10.5551\/jat.43141"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Haroon NN, Paterson JM, and Li P: Patients With Ankylosing Spondylitis Have Increased Cardiovascular and Cerebrovascular Mortality: A Population-Based Study. Annals of internal medicine, 2015: 163: 409-416","DOI":"10.7326\/M14-2470"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Angel K, Provan SA, and Fagerhol MK: Effect of 1-year anti-TNF-alpha therapy on aortic stiffness, carotid atherosclerosis, and calprotectin in inflammatory arthropathies: a controlled study. Am J Hypertens, 2012; 25: 64450","DOI":"10.1038\/ajh.2012.12"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Tam LS, Li EK, and Shang Q: Tumour necrosis factor alpha blockade is associated with sustained regression of carotid intima-media thickness for patients with active psoriatic arthritis: a 2-year pilot study. Ann Rheum Dis, 2011; 70: 7056","DOI":"10.1136\/ard.2010.131359"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Libby P, Ridker PM, and Maseri A: Inflammation and atherosclerosis. Circulation, 2002; 105: 1135-1143","DOI":"10.1161\/hc0902.104353"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Chen CH, Chen HA, and Liao HT: The clinical usefulness of ESR, CRP, and disease duration in ankylosing spondylitis: the product of these acute-phase reactants and disease duration is associated with patient's poor physical mobility. Rheumatol Int, 2015; 35: 1263","DOI":"10.1007\/s00296-015-3214-4"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Zieske AW, Tracy RP, and McMahan CA: Elevated serum C-reactive protein levels and advanced atherosclerosis in youth. Arterioscler Thromb Vasc Biol, 2005; 25: 1237-1243","DOI":"10.1161\/01.ATV.0000164625.93129.64"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Divecha H, Sattar N, and Rumley A: Cardiovascular risk parameters in men with ankylosing spondylitis in comparison with non-inflammatory control subjects: relevance of systemic inflammation. Clin Sci (London), 2005; 109: 171-176","DOI":"10.1042\/CS20040326"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Hansson GK, Robertson AK, and S\u00f6derberg-Naucl\u00e9r C: Inflammation and atherosclerosis. Annu Rev Pathol, 2006; 1: 297-329","DOI":"10.1146\/annurev.pathol.1.110304.100100"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Kubota M, Yoneda M, and Watanabe H: Progression of Carotid Atherosclerosis in Two Japanese Populations with Different Lifestyles. J Atheroscler Thromb. 2017; 24: 1069-1074","DOI":"10.5551\/jat.39578"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Raitakari OT, Juonala M, and K\u00e4h\u00f6nen M: Cardiovascular risk factors in childhood and carotid artery intimamedia thickness in adulthood. JAMA, 2003; 290: 2277- 2283","DOI":"10.1001\/jama.290.17.2277"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Lee SW, Hai JJ, and Kong SL: Side differences of carotid intima-media thickness in predicting cardiovascular events among patients with coronary artery disease. Angiology, 2011; 62: 231-236","DOI":"10.1177\/0003319710379109"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Bots ML, de Jong PT, and Hofman A: Left, right, near or far wall common carotid intima-media thickness measurements: Associations with cardiovascular disease and lower extremity arterial atherosclerosis. J Clin Epidemiol, 1997; 50: 801-807","DOI":"10.1016\/S0895-4356(97)00059-0"}],"container-title":["Journal of Atherosclerosis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/26\/3\/26_45294\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:14:53Z","timestamp":1571703293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/26\/3\/26_45294\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,1]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.5551\/jat.45294","relation":{},"ISSN":["1340-3478","1880-3873"],"issn-type":[{"value":"1340-3478","type":"print"},{"value":"1880-3873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,1]]}}}