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Increased common carotid intima-media thickness. Adaptive response or a reflection of atherosclerosis? Findings from the Rotterdam Study. Stroke, 1997; 28: 2442-2447","DOI":"10.1161\/01.STR.28.12.2442"},{"key":"33","doi-asserted-by":"crossref","unstructured":"34) Moskau S, Golla A, Grothe C, Boes M, Pohl C, Klockgether T. Heritability of carotid artery atherosclerotic lesions: an ultrasound study in 154 families. Stroke, 2005; 36: 5-8","DOI":"10.1161\/01.STR.0000149936.33498.83"},{"key":"34","doi-asserted-by":"crossref","unstructured":"35) Zureik M, Temmar M, Adamopoulos C, Bureau JM, Courbon D, Thomas F, Bean K, Touboul PJ, Ducimeti\u00e8re P, Benetos A. Carotid plaques, but not common carotid intima-media thickness, are independently associated with aortic stiffness. J Hypertens, 2002; 20: 85-93","DOI":"10.1097\/00004872-200201000-00013"},{"key":"35","doi-asserted-by":"crossref","unstructured":"36) Nikuei P, Rajaei M, Malekzadeh K, Nejatizadeh A, Mohseni F and AtashAbParvar A. 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