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J Lab Clin Med, 1998; 132: 195-201","DOI":"10.1016\/S0022-2143(98)90168-8"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Sakaue T, Hirano T, Yoshino G, Sakai K, Takeuchi H, and Adachi M. Reactions of direct LDL-cholesterol assays with pure LDL fraction and IDL: comparison of three homogeneous methods. Clin Chim Acta, 2000; 295: 97-106","DOI":"10.1016\/S0009-8981(00)00200-X"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Otokozawa S, Ai M, Asztalos BF, White CC, Demissie-Banjaw S, Cupples LA, Nakajima K, Wilson PW, and Schaefer EJ. Direct assessment of plasma low density lipoprotein and high density lipoprotein cholesterol. Atherosclerosis, 2010; 213: 251-255","DOI":"10.1016\/j.atherosclerosis.2010.02.041"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Griffin BA. Lipoprotein atherogenicity: an overview of current mechanisms. Proc Nutr Soc, 1999; 58: 163-169","DOI":"10.1079\/PNS19990022"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Campos H, Genest JJ, Blijlevens E, McNamara JR, Jenner JL, Ordovas JM, Wilson PW, and Schaefer EJ. Low density lipoprotein particle size and coronary artery disease. Arterioscler Thromb, 1992; 12: 187-195","DOI":"10.1161\/01.ATV.12.2.187"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) McNamara JR, Jenner JL, Li Z, Wilson PWF, and Schaefer EJ. Change in low density lipoprotein particle size in associated with change in plasma triglyceride concentration. Arterioscler Thromb, 1992; 12: 1284-1290","DOI":"10.1161\/01.ATV.12.11.1284"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Campos H, Blijlevens E, McNamara JR, Ordovas JM, Wilson PWF, and Schaefer EJ. LDL particle size distribution: results from the Framingham Offspring Study. Arterioscler Thromb, 1992; 12: 1410-1419","DOI":"10.1161\/01.ATV.12.12.1410"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Hirano T, Ito Y, Saegusa H, and Yoshino G. A novel and simple method for quantification of small dense LDL. J Lipid Res, 2003; 44: 2193-2201","DOI":"10.1194\/jlr.D300007-JLR200"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Ito Y, Fujimura M, Ohta M, and Hirano T. Development of a homogeneous assay for measurement of small dense LDL cholesterol. Clin Chem, 2011; 57: 57-65","DOI":"10.1373\/clinchem.2010.149559"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Koba S, Yokota Y, Hirano T, Ito Y, Ban Y, Tsunoda F, Sato T, Shoji M, Suzuki H, Geshi E, Kobayashi Y, and Katagiri T. Small LDL-cholesterol is superior to LDL-cholesterol for determining severity of coronary atherosclerosis. J Atheroscler Thromb, 2008; 15: 250-260","DOI":"10.5551\/jat.E572"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Ai M, Otokozawa S, Asztalos BF, Ito Y, Nakajima K, White CC, Cupples LA, Wilson PW, and Schaefer EJ. Small dense LDL cholesterol and coronary heart disease: results from the Framingham Offspring Study. Clin Chem, 2010; 56: 967-976","DOI":"10.1373\/clinchem.2009.137489"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Arai H, Kokubo Y, Watanabe M, Sawamura T, Ito Y, Minagawa A, Okamura T, and Miyamato Y. Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: the Suita study. J Atheroscler Thromb, 2013; 20: 195-203","DOI":"10.5551\/jat.14936"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Hoogeveen RC, Gaubatz JW, Sun W, Dodge RC, Crosby JR, Jiang J, Couper D, Virani SS, Kathiresan S, Boerwinkle E, and Ballantyne CM. 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J Atheroscler Thromb, 2019; 26: 624-635","DOI":"10.5551\/jat.43968"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Burke GL, Evans GW, Riley WA, Sharrett AR, Howard G, Barnes RW, Rosamond W, Crow RS, Rautaharju PM, and Heiss G. Arterial wall thickness is associated with prevalent cardiovascular disease in middle-aged adults. The Atherosclerosis Risk in Communities (ARIC) Study. Stroke, 1995; 26: 386-391","DOI":"10.1161\/01.STR.26.3.386"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Raitakari OT, Juonala M, K\u00e4h\u00f6nen M, Taittonen L, Laitinen T, M\u00e4ki-Torkko N, J\u00e4rvisalo MJ, Uhari M, Jokinen E, R\u00f6nnemaa T, Akerblom HK, and Viikari JS. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. JAMA, 2003; 290: 2277-2283","DOI":"10.1001\/jama.290.17.2277"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Iino H, Okano T, Daimon M, Sasaki K, Chigira M, Nakano T, Mizuno Y, Yamazaki T, Kurano M, Yatomi Y, Sumi Y, Sasano T, and Miyata T. Usefulness of carotid arterial strain values for evaluating the arteriosclerosis. J Atheroscler Thromb, 2019; 26: 476-487","DOI":"10.5551\/jat.45591"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Castelli WP, Anderson K, Wilson PW, and Levy D. Lipids and risk of coronary heart disease. The Framingham Study. Ann Epidemiol, 1992; 2: 23-28","DOI":"10.1016\/1047-2797(92)90033-M"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Amarenco P, Labreuche J, Lavall\u00e9e P, and Touboul PJ. Statins in stroke prevention and carotid atherosclerosis: systematic review and up-to-date meta-analysis. 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CKD, plasma lipids, and common carotid intima-media thickness: results from the multi-ethnic study of atherosclerosis. Clin J Am Soc Nephrol, 2012; 7: 1777-1785","DOI":"10.2215\/CJN.02090212"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Gentile M, Panico S, Mattiello A, Ubaldi S, Iannuzzo G, De Michele M, Iannuzzi A, and Rubba P. Association between small dense LDL and early atherosclerosis in a sample of menopausal women. Clin Chim Acta, 2013; 426: 1-5","DOI":"10.1016\/j.cca.2013.08.010"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Aoki T, Yagi H, Sumino H, Tsunekawa K, Araki O, Kimura T, Nara M, Ogiwara T, Nakajima K, and Murakami M. Relationship between carotid artery intimamedia thickness and small dense low-density lipoprotein cholesterol concentrations measured by homogenous assay in Japanese subjects. Clin Chim Acta, 2015; 442: 110-114","DOI":"10.1016\/j.cca.2015.01.010"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Furusyo N, Koga T, Ai M, Otokozawa S, Kohzuma T, Ikezaki H, Schaefer EJ, and Hayashi J. The serum undercarboxylated osteocalcin level and the diet of a Japanese population: Results from the Kyushu and Okinawa Population Study (KOPS). Endocrine, 2013; 43: 635-642","DOI":"10.1007\/s12020-012-9803-z"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Ikezaki H, Furusyo N, Jacques PF, Shimizu M, Murata M, Schaefer EJ, Urita Y, and Hayashi J. Higher dietary cholesterol and \u03c9-3 fatty acid intakes are associated with a lower success rate of Helicobacter pylori eradication therapy in Japan. Am J Clin Nutri, 2017; 106: 581-588","DOI":"10.3945\/ajcn.116.144873"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Ikezaki H, Ai M, Schaefer EJ, Otokozawa S, Asztalos BF, Nakajima K, Zhou Y, Liu CT, Jacques PF, Cupples LA, and Furusyo N. 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Development of a homogeneous assay for measurement of high-density lipoprotein-subclass cholesterol. Clin Chim Acta, 2014; 427: 86-93","DOI":"10.1016\/j.cca.2013.09.009"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Ikezaki H, Fisher VA, Lim E, Ai M, Liu CT, Cupples LA, Nakajima K, Asztalos BF, Furusyo N, and Schaefer EJ. Direct versus calculated low-density lipoprotein cholesterol and C reactive protein in cardiovascular disease risk assessment in the Framingham Offspring Study. Clin Chem, 2019; 65: 1102-1114","DOI":"10.1373\/clinchem.2019.304600"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Yanase T, Nasu S, Mukuta Y, Shimizu Y, Nishihara T, Okabe T, Nomura M, Inoguchi T, and Nawata H. Evaluation of a new carotid intima-media thickness measurement by B-mode ultrasonography using an innovative measurement software, intimascope. 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J Clin Lipidol, 2015; 9: 129-169","DOI":"10.1016\/j.jacl.2015.02.003"},{"key":"44","unstructured":"44) Expert Dyslipidemia Panel of the International Atherosclerosis Society Panel members. An International Atherosclerosis Society Position Paper: global recommendations for the management of dyslipidemia - full report. J Clin Lipidol, 2014; 8: 29-60"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Thongtang N, Diffenderfer MR, Ooi EM, Barrett PHR, Turner SM, Le NA, Brown WV, and Schaefer EJ. Metabolism and proteomics of large and small dense LDL in combined hyperlipidemia. Effects of rosuvastatin. J Lipid Res, 2017; 58: 1315-1324","DOI":"10.1194\/jlr.M073882"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Hurt-Camejo E, Olsson U, Wiklund O, Bondjers G, and Camejo G. Cellular consequences of the association of apoB lipoproteins with proteoglycans. Potential contribution to atherogenesis. 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