{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:41:02Z","timestamp":1784043662268,"version":"3.55.0"},"reference-count":25,"publisher":"Japan Atherosclerosis Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAT","J Atheroscler Thromb"],"published-print":{"date-parts":[[2022,11,1]]},"DOI":"10.5551\/jat.63151","type":"journal-article","created":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T22:08:45Z","timestamp":1641679725000},"page":"1603-1612","source":"Crossref","is-referenced-by-count":21,"title":["Association between Achilles Tendon Softness and Atherosclerotic Cardiovascular Disease in Patients with Familial Hypercholesterolemia"],"prefix":"10.5551","volume":"29","author":[{"given":"Masahito","family":"Michikura","sequence":"first","affiliation":[{"name":"Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute"},{"name":"Department of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatsune","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute"},{"name":"Department of General Medical Science, Chiba University Graduate School of Medicine"},{"name":"Department of Metabolism and Endocrinology, Eastern Chiba Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute"},{"name":"Department of Endocrinology, Research Institute of Environmental Medicine, Nagoya University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Matsuki","sequence":"additional","affiliation":[{"name":"Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute"},{"name":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiminori","family":"Hosoda","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Harada-Shiba","sequence":"additional","affiliation":[{"name":"Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute"},{"name":"Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3489","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Defesche JC, Gidding SS, Harada-Shiba M, Hegele RA, Santos RD and Wierzbicki AS: Familial hypercholesterolaemia. Nat Rev Dis Primers, 2017; 3: 17093","DOI":"10.1038\/nrdp.2017.93"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Mabuchi H, Nohara A, Noguchi T, Kobayashi J, Kawashiri MA, Tada H, Nakanishi C, Mori M, Yamagishi M, Inazu A, Koizumi J and Hokuriku FHSG: Molecular genetic epidemiology of homozygous familial hypercholesterolemia in the Hokuriku district of Japan. Atherosclerosis, 2011; 214: 404-407","DOI":"10.1016\/j.atherosclerosis.2010.11.005"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Nordestgaard BG, Chapman MJ, Humphries SE, Ginsberg HN, Masana L, Descamps OS, Wiklund O, Hegele RA, Raal FJ, Defesche JC, Wiegman A, Santos RD, Watts GF, Parhofer KG, Hovingh GK, Kovanen PT, Boileau C, Averna M, Boren J, Bruckert E, Catapano AL, Kuivenhoven JA, Pajukanta P, Ray K, Stalenhoef AF, Stroes E, Taskinen MR and Tybjaerg-Hansen A: Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society. Eur Heart J, 2013; 34: 3478-3490a","DOI":"10.1093\/eurheartj\/eht273"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Harada-Shiba M, Ako J, Arai H, Hirayama A, Murakami Y, Nohara A, Ozaki A, Uno K and Nakamura M: Prevalence of familial hypercholesterolemia in patients with acute coronary syndrome in Japan: Results of the EXPLORE-J study. Atherosclerosis, 2018; 277: 362-368","DOI":"10.1016\/j.atherosclerosis.2018.06.856"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Ohmura H, Fukushima Y, Mizuno A, Niwa K, Kobayashi Y, Ebina T, Kimura K, Ishibashi S, Daida H, Research Committee on Primary Hyperlipidemia of the Ministry of H and Welfare of J: Estimated Prevalence of Heterozygous Familial Hypercholesterolemia in Patients With Acute Coronary Syndrome. Int Heart J, 2017; 58: 88-94","DOI":"10.1536\/ihj.16-188"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Nanchen D, Gencer B, Auer R, Raber L, Stefanini GG, Klingenberg R, Schmied CM, Cornuz J, Muller O, Vogt P, Juni P, Matter CM, Windecker S, Luscher TF, Mach F and Rodondi N: Prevalence and management of familial hypercholesterolaemia in patients with acute coronary syndromes. Eur Heart J, 2016: 36: 2438-2445","DOI":"10.1093\/eurheartj\/ehv289"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Representatives of the Global Familial Hypercholesterolemia C, Wilemon KA, Patel J, Aguilar-Salinas C, Ahmed CD, Alkhnifsawi M, Almahmeed W, Alonso R, Al-Rasadi K, Badimon L, Bernal LM, Bogsrud MP, Braun LT, Brunham L, Catapano AL, Cillikova K, Corral P, Cuevas R, Defesche JC, Descamps OS, de Ferranti S, Eisele JL, Elikir G, Folco E, Freiberger T, Fuggetta F, Gaspar IM, Gesztes AG, Groselj U, Hamilton-Craig I, Hanauer-Mader G, Harada-Shiba M, Hastings G, Hovingh GK, Izar MC, Jamison A, Karlsson GN, Kayikcioglu M, Koob S, Koseki M, Lane S, Lima-Martinez MM, Lopez G, Martinez TL, Marais D, Marion L, Mata P, Maurina I, Maxwell D, Mehta R, Mensah GA, Miserez AR, Neely D, Nicholls SJ, Nohara A, Nordestgaard BG, Ose L, Pallidis A, Pang J, Payne J, Peterson AL, Popescu MP, Puri R, Ray KK, Reda A, Sampietro T, Santos RD, Schalkers I, Schreier L, Shapiro MD, Sijbrands E, Soffer D, Stefanutti C, Stoll M, Sy RG, Tamayo ML, Tilney MK, Tokgozoglu L, Tomlinson B, Vallejo-Vaz AJ, Vazquez-Cardenas A, de Luca PV, Wald DS, Watts GF, Wenger NK, Wolf M, Wood D, Zegerius A, Gaziano TA and Gidding SS: Reducing the Clinical and Public Health Burden of Familial Hypercholesterolemia: A Global Call to Action. JAMA Cardiol, 2020; 5: 217-229","DOI":"10.1001\/jamacardio.2019.5173"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Harada-Shiba M, Arai H, Ishigaki Y, Ishibashi S, Okamura T, Ogura M, Dobashi K, Nohara A, Bujo H, Miyauchi K, Yamashita S, Yokote K and Working Group by Japan Atherosclerosis Society for Making Guidance of Familial H: Guidelines for Diagnosis and Treatment of Familial Hypercholesterolemia 2017. J Atheroscler Thromb, 2018; 25: 751-770","DOI":"10.5551\/jat.CR003"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Mabuchi H, Ito S, Haba T, Ueda K and Ueda R: Discrimination of familial hypercholesterolemia and secondary hypercholesterolemia by Achilles\u2019 tendon thickness. Atherosclerosis, 1977; 28: 61-68","DOI":"10.1016\/0021-9150(77)90199-X"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Tada H, Hori M, Matsuki K, Ogura M, Nohara A, Kawashiri M, and Harada-Shiba M: Achilles Tendon Thickness Assessed by X-ray Predicting a Pathogenic Mutation in Familial Hypercholesterolemia Gene. J Atheroscler Thromb, 2022; 29: 816-824","DOI":"10.5551\/jat.62869"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Tsouli SG, Kiortsis DN, Argyropoulou MI, Mikhailidis DP and Elisaf MS: Pathogenesis, detection and treatment of Achilles tendon xanthomas. Eur J Clin Invest, 2005; 35: 236-244","DOI":"10.1111\/j.1365-2362.2005.01484.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Michikura M, Ogura M, Yamamoto M, Sekimoto M, Fuke C, Hori M, Arai K, Kihara S, Hosoda K, Yanagi K and Harada-Shiba M: Achilles Tendon Ultrasonography for Diagnosis of Familial Hypercholesterolemia Among Japanese Subjects. Circ J, 2017; 81: 1879-1885","DOI":"10.1253\/circj.CJ-17-0041"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Michikura M, Ogura M, Hori M, Furuta K, Hosoda K and Harada-Shiba M: Achilles Tendon Softness as a New Tool for Diagnosing Familial Hypercholesterolemia. JACC Cardiovasc Imaging, 2021; 17: 1483-1485","DOI":"10.1016\/j.jcmg.2021.01.033"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Zhang L, Yong Q, Pu T, Zheng C, Wang M, Shi S and Li L: Grayscale ultrasonic and shear wave elastographic characteristics of the Achilles\u2019 tendon in patients with familial hypercholesterolemia: A pilot study. Eur J Radiol, 2018; 109: 1-7","DOI":"10.1016\/j.ejrad.2018.10.003"},{"key":"15","unstructured":"15) Sugiyama N, Marcovina S, Gown AM, Seftel H, Joffe B and Chait A: Immunohistochemical distribution of lipoprotein epitopes in xanthomata from patients with familial hypercholesterolemia. Am J Pathol, 1992; 141: 99-106"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Hori M, Ohta N, Takahashi A, Masuda H, Isoda R, Yamamoto S, Son C, Ogura M, Hosoda K, Miyamoto Y and Harada-Shiba M: Impact of LDLR and PCSK9 pathogenic variants in Japanese heterozygous familial hypercholesterolemia patients. Atherosclerosis, 2019; 289: 101-108","DOI":"10.1016\/j.atherosclerosis.2019.08.004"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Schneebeli A, Del Grande F, Vincenzo G, et al.: Real-time ultrasound elastography using an external reference material: test-retest reliability of healthy Achilles tendons. Skeletal Radiol, 2016; 45(8): 1045-1052","DOI":"10.1007\/s00256-016-2382-y"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Foure A: New Imaging Methods for Non-invasive Assessment of Mechanical, Structural, and Biochemical Properties of Human Achilles Tendon: A Mini Review. Front Physiol, 2016; 7: 324","DOI":"10.3389\/fphys.2016.00324"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Sun Y, Ma C, Liang X, Wang R, Fu Y, Wang S, Cui L and Zhang C: Reproducibility analysis on shear wave elastography (SWE)-based quantitative assessment for skin elasticity. Medicine (Baltimore), 2017; 96: e6902","DOI":"10.1097\/MD.0000000000006902"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Sugisawa T, Okamura T, Makino H, Watanabe M, Kishimoto I, Miyamoto Y, Iwamoto N, Yamamoto A, Yokoyama S, Harada-Shiba M: Defining patients at extremely high risk for coronary artery disease in heterozygous familial hypercholesterolemia. J Atheroscler Thromb, 2012; 19: 369-375","DOI":"10.5551\/jat.11536"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Ogura M, Hori M and Harada-Shiba M: Association between cholesterol efflux capacity and atherosclerotic cardiovascular disease in patients with familial hypercholesterolemia. Arterioscler Thromb Vasc Biol, 36: 181-188","DOI":"10.1161\/ATVBAHA.115.306665"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Ogura M, Harada-Shiba M, Masuda D, Arai H, Bujo H, Ishibashi S, Daida H, Koga N, Oikawa S, Yamashita S, FAME Study Group: Factors Associated with Carotid Atherosclerosis and Achilles Tendon Thickness in Japanese Patients with Familial Hypercholesterolemia: A Subanalysis of the Familial Hypercholesterolemia Expert Forum (FAME) Study. J Atheroscler Thromb, 2022; 29: 906-922","DOI":"10.5551\/jat.62925"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Tada H, Kawashiri MA, Nohara A, Inazu A, Mabuchi H and Yamagishi M: Impact of clinical signs and genetic diagnosis of familial hypercholesterolaemia on the prevalence of coronary artery disease in patients with severe hypercholesterolaemia. Eur Heart J, 2017; 38: 1573-1579","DOI":"10.1093\/eurheartj\/ehx004"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Irie Y, Katakami N, Kaneto H, Kasami R, Sumitsuji S, Yamasaki K, Tachibana K, Kuroda T, Sakamoto K, Umayahara Y, Ueda Y, Kosugi K and Shimomura I: Maximum carotid intima-media thickness improves the prediction ability of coronary artery stenosis in type 2 diabetic patients without history of coronary artery disease. Atherosclerosis, 2012; 221: 438-444","DOI":"10.1016\/j.atherosclerosis.2012.01.022"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Fujihara K, Suzuki H, Sato A, Ishizu T, Kodama S, Heianza Y, Saito K, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Yahagi N, Sone H and Shimano H: Comparison of the Framingham risk score, UK Prospective Diabetes Study (UKPDS) Risk Engine, Japanese Atherosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) and maximum carotid intima-media thickness for predicting coronary artery stenosis in patients with asymptomatic type 2 diabetes. J Atheroscler Thromb, 2014; 21: 799-815","DOI":"10.5551\/jat.20487"}],"container-title":["Journal of Atherosclerosis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/29\/11\/29_63151\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T04:49:05Z","timestamp":1715316545000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/29\/11\/29_63151\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,1]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.5551\/jat.63151","relation":{},"ISSN":["1340-3478","1880-3873"],"issn-type":[{"value":"1340-3478","type":"print"},{"value":"1880-3873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,1]]},"article-number":"63151"}}