{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T05:10:25Z","timestamp":1738473025549,"version":"3.35.0"},"reference-count":25,"publisher":"Japan Atherosclerosis Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAT","J Atheroscler Thromb"],"published-print":{"date-parts":[[2025,2,1]]},"DOI":"10.5551\/jat.64681","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T22:31:01Z","timestamp":1727476261000},"page":"176-187","source":"Crossref","is-referenced-by-count":0,"title":["Antiplatelets for Cardiovascular Disease in Non-valvular AF with Rivaroxaban: A Subanalysis of the EXPAND Study"],"prefix":"10.5551","volume":"32","author":[{"given":"Koichi","family":"Kaikita","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki"},{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Medicine, Center for Brain and Cerebral Vessels, Sanno Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotsugu","family":"Atarashi","sequence":"additional","affiliation":[{"name":"Nippon Medical School"},{"name":"Tama Nagayama Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Saiseikai Toyama Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanari","family":"Kitazono","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Nippon Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Toho University Faculty of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kamouchi","sequence":"additional","affiliation":[{"name":"Department of Health Care Administration and Management, Center for Cohort Study, Kyushu University Graduate School of Medical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Division of Heart Rhythm, International University of Health and Welfare Hospital, International University of Health and Welfare"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Origasa","sequence":"additional","affiliation":[{"name":"The Institute of Statistical Mathematics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Shimokawa","sequence":"additional","affiliation":[{"name":"Graduate School, International University of Health and Welfare"},{"name":"Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3489","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland Jr JC, Ellinor PT, Ezekowitz MD, Field ME, Furie KL, Heidenreich PA, Murray KT, Shea JB, Tracy CM, Yancy CW: 2019 AHA\/ACC\/HRS focused update of the 2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on clinical practice guidelines and the Heart Rhythm Society in collaboration with the Society of Thoracic Surgeons. Circulation, 2019; 140: e125-e151","DOI":"10.1161\/CIR.0000000000000665"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomstr\u00f6m-Lundqvist C, Boriani G, Castella M, Dan G-A, Dilaveris PE, Fauchier L, Filippatos G, Kalman JM, La Meir M, Lane DA, Lebeau J-P, Lettino M, Lip GYH, Pinto FJ, Thomas GN, Valgimigli M, Van Gelder IC, Van Putte BP, Watkins CL; ESC Scientific Document Group: 2020 ESC guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J, 2021; 42: 373-498","DOI":"10.1093\/eurheartj\/ehab648"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Ono K, Iwasaki YK, Akao M, Ikeda T, Ishii K, Inden Y, Kusano K, Kobayashi Y, Koretsune Y, Sasano T, Sumitomo N, Takahashi N, Niwano S, Hagiwara N, Hisatome I, Furukawa T, Honjo H, Maruyama T, Murakawa Y, Yasaka M, Watanabe E, Aiba T, Amino M, Itoh H, Ogawa H, Okumura Y, Aoki-Kamiya C, Kishihara J, Kodani E, Komatsu T, Sakamoto Y, Satomi K, Shiga T, Shinohara T, Suzuki A, Suzuki S, Sekiguchi Y, Nagase S, Hayami N, Harada M, Fujino T, Makiyama T, Maruyama M, Miake J, Muraji S, Murata H, Morita N, Yokoshiki H, Yoshioka K, Yodogawa K, Inoue H, Okumura K, Kimura T, Tsutsui H, Shimizu W; Japanese Circulation Society and Japanese Heart Rhythm Society Joint Working Group: JCS\/JHRS 2020 guideline on pharmacotherapy of cardiac arrhythmias. Circ J, 2022; 86: 1790-1924","DOI":"10.1253\/circj.CJ-20-1212"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Odutayo A, Wong CX, Hsiao AJ, Hopewell S, Altman DG, Emdin CA: Atrial fibrillation and risks of cardiovascular disease, renal disease, and death: systematic review and meta-analysis. BMJ, 2016; 354: i4482","DOI":"10.1136\/bmj.i4482"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Wolf PA, Abbott RD, Kannel WB: Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke, 1991; 22: 983-988","DOI":"10.1161\/01.STR.22.8.983"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Dulli DA, Stanko H, Levine RL: Atrial fibrillation is associated with severe acute ischemic stroke. Neuroepidemiology, 2003; 22: 118-123","DOI":"10.1159\/000068743"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Proietti M, Raparelli V, Laroche C, Dan G-A, Janion M, Popescu R, Sinagra G, Vijgen J, Boriani G, Maggioni AP, Tavazzi L, Lip GYH; on behalf of the EORP-AF Gen Pilot Investigators: Adverse outcomes in patients with atrial fibrillation and peripheral arterial disease: a report from the EURObservational research programme pilot survey on atrial fibrillation. Europace, 2017; 19: 1439-1448","DOI":"10.1093\/europace\/euw169"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Gonzalez ER: Antiplatelet therapy in atherosclerotic cardiovascular disease. Clin Ther, 1998; 20: B18-B41","DOI":"10.1016\/S0149-2918(98)80028-3"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Hiatt WR, Fowkes FGR, Heizer G, Berger JS, Baumgartner I, Held P, Katona BG, Mahaffey KW, Norgren L, Jones WS, Blomster J, Milleg\u00e5rd M, Reist C, Patel MR; for the EUCLID Trial Steering Committee and Investigators: Ticagrelor versus clopidogrel in symptomatic peripheral artery disease. N Engl J Med, 2017; 376: 32-40","DOI":"10.1056\/NEJMoa1611688"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Berger JS, Krantz MJ, Kittelson JM, Hiatt WR: Aspirin for the prevention of cardiovascular events in patients with peripheral artery disease: a meta-analysis of randomized trials. JAMA, 2009; 301: 1909-1919","DOI":"10.1001\/jama.2009.623"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Eikelboom JW, Connolly SJ, Bosch J, Dagenais GR, Hart RG, Shestakovska O, Diaz R, Alings M, Lonn EM, Anand SS, Widimsky P, Hori M, Avezum A, Piegas LS, Branch KRH, Probstfield J, Bhatt DL, Zhu J, Liang Y, Maggioni AP, Lopez-Jaramillo P, O\u2019Donnell M, Kakkar AK, Fox KAA, Parkhomenko AN, Ertl G, St\u00f6rk S, Keltai M, Ryden L, Pogosova N, Dans AL, Lanas F, Commerford PJ, Torp-Pedersen C, Guzik TJ, Verhamme PB, Vinereanu D, Kim J-H, Tonkin AM, Lewis BS, Felix C, Yusoff K, Steg PG, Metsarinne KP, Bruns NC, Misselwitz F, Chen E, Leong D, Yusuf S; COMPASS Investigators: Rivaroxaban with or without aspirin in stable cardiovascular disease. N Engl J Med, 2017; 377: 1319-1330","DOI":"10.1056\/NEJMoa1709118"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Yasuda S, Kaikita K, Akao M, Ako J, Matoba T, Nakamura M, Miyauchi K, Hagiwara N, Kimura K, Hirayama A, Matsui K, Ogawa H; AFIRE Investigators: Antithrombotic therapy for atrial fibrillation with stable coronary disease. N Engl J Med, 2019; 381: 1103-1113","DOI":"10.1056\/NEJMoa1904143"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Shimokawa H, Yamashita T, Uchiyama S, Kitazono T, Shimizu W, Ikeda T, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Sakuma I, Saku K, Okumura Y, Nakamura Y, Morimoto H, Matsumoto N, Tsuchida A, Ako J, Sugishita N, Shimizu S, Atarashi H, Inoue H: The EXPAND study: efficacy and safety of rivaroxaban in Japanese patients with non-valvular atrial fibrillation. Int J Cardiol, 2018; 258: 126-132","DOI":"10.1016\/j.ijcard.2018.01.141"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Ikeda T, Atarashi H, Inoue H, Uchiyama S, Kitazono T, Yamashita T, Shimizu W, Kamouchi M, Kaikita K, Fukuda K, Origasa H, Sakuma I, Saku K, Okumura Y, Nakamura Y, Morimoto H, Matsumoto N, Tsuchida A, Ako J, Sugishita N, Shimizu S, Shimokawa H: Study design and baseline characteristics of the EXPAND study: evaluation of effectiveness and safety of Xa inhibitor, rivaroxaban for the prevention of stroke and systemic embolism in a nationwide cohort of Japanese patients diagnosed as non-valvular atrial fibrillation. Tohoku J Exp Med, 2016; 240: 259-268","DOI":"10.1620\/tjem.240.259"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Hori M, Matsumoto M, Tanahashi N, Momomura S-I, Uchiyama S, Goto S, Izumi T, Koretsune Y, Kajikawa M, Kato M, Ueda H, Iwamoto K, Tajiri M; J-ROCKET AF Study Investigators: Rivaroxaban vs. warfarin in Japanese patients with atrial fibrillation \u2013 the J-ROCKET AF study \u2013. Circ J, 2012; 76: 2104-2111","DOI":"10.1253\/circj.CJ-12-0454"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Kaatz S, Ahmad D, Spyropoulos AC, Schulman S; Subcommittee on Control of Anticoagulation: Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH. J Thromb Haemost, 2015; 13: 2119-2126","DOI":"10.1111\/jth.13140"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Matsuzawa Y, Kimura K, Yasuda S, Kaikita K, Akao M, Ako J, Matoba T, Nakamura M, Miyauchi K, Hagiwara N, Hirayama A, Matsui K, Ogawa H; AFIRE Investigators: Antithrombotic therapy for atrial fibrillation and coronary artery disease in patients with prior atherothrombotic disease: a post hoc analysis of the AFIRE trial. J Am Heart Assoc, 2021; 10: e020907","DOI":"10.1161\/JAHA.121.020907"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Kleindorfer DO, Towfighi A, Chaturvedi S, Cockroft KM, Gutierrez J, Lombardi-Hill D, Kamel H, Kernan WN, Kittner SJ, Leira EC, Lennon O, Meschia JF, Nguyen TN, Pollak PM, Santangeli P, Sharrief AZ, Smith Jr SC, Turan TN, Williams LS: 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association\/American Stroke Association. Stroke, 2021; 52: e364-e467","DOI":"10.1161\/STR.0000000000000375"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Dawson J, B\u00e9jot Y, Christensen LM, De Marchis GM, Dichgans M, Hagberg G, Heldner MR, Milionis H, Li L, Pezzella FR, Rowan MT, Tiu C, Webb A: European Stroke Organisation (ESO) guideline on pharmacological interventions for long-term secondary prevention after ischaemic stroke or transient ischemic attack. Eur Stroke J, 2022; 7: I-II","DOI":"10.1177\/23969873221100032"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, B\u00e4ck M, Benetos A, Biffi A, Boavida J-M, Capodanno D, Cosyns B, Crawford C, Davos CH, Desormais I, Di Angelantonio E, Franco OH, Halvorsen S, Hobbs FDR, Hollander M, Jankowska EA, Michal M, Sacco S, Sattar N, Tokgozoglu L, Tonstad S, Tsioufis KP, van Dis I, van Gelder IC, Wanner C, Williams B; ESC Scientific Document Group: 2021 ESC guidelines on cardiovascular disease prevention in clinical practice: developed by the Task Force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies with the special contribution of the European Association of Preventive Cardiology (EAPC). Rev Esp Cardiol, 2022; 75: 429","DOI":"10.1016\/j.rec.2022.04.003"},{"key":"21","unstructured":"21) Aboyans V, Ricco J-B, Bartelink M-LEL, Bj\u00f6rck M, Brodmann M, Cohnert T, Collet J-P, Czerny M, De Carlo M, Debus S, Espinola-Klein C, Kahan T, Kownator S, Mazzolai L, Naylor AR, Roffi M, R\u00f6ther J, Sprynger M, Tendera M, Tepe G, Venermo M, Vlachopoulos C, Desormais I; ESC Scientific Document Group: 2017 ESC guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the European Society for Vascular Surgery (ESVS): document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries endorsed by: the European Stroke Organization (ESO) The Task Force for the diagnosis and treatment of peripheral arterial diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery. Eur Heart J, 2018; 39: 763-816"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Nakamura M, Kimura K, Kimura T, Ishihara M, Otsuka F, Kozuma K, Kosuge M, Shinke T, Nakagawa Y, Natsuaki M, Yasuda S, Akasaka T, Kohsaka S, Haze K, Hirayama A: JCS 2020 guidelines focused update on antithrombotic therapy in patients with coronary artery disease. Circ J, 2020; 84: 831-865","DOI":"10.1253\/circj.CJ-19-1109"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Kumbhani DJ, Cannon CP, Beavers CJ, Bhatt DL, Cuker A, Gluckman TJ, Marine JE, Mehran R, Messe SR, Patel NS, Peterson BE, Rosenfield K, Spinler SA, Thourani VH: 2020 ACC expert consensus decision pathway for anticoagulant and antiplatelet therapy in patients with atrial fibrillation or venous thromboembolism undergoing percutaneous coronary intervention or with atherosclerotic cardiovascular disease: a report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol, 2021; 77: 629-658","DOI":"10.1016\/j.jacc.2020.09.011"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Perzborn E, Heitmeier S, Laux V: Effects of rivaroxaban on platelet activation and platelet\u2013coagulation pathway interaction: in vitro and in vivo studies. J Cardiovasc Pharmacol Ther, 2015; 20: 554-562","DOI":"10.1177\/1074248415578172"},{"key":"25","unstructured":"25) Editorial Committee of Japan Stroke Data Bank 2021: In: National Cerebral and Cardiovascular Center. Japan Stroke Data Bank 2021. Nakayama Shoten, Tokyo, 2021"}],"container-title":["Journal of Atherosclerosis and Thrombosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/32\/2\/32_64681\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T04:36:37Z","timestamp":1738384597000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jat\/32\/2\/32_64681\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,1]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.5551\/jat.64681","relation":{},"ISSN":["1340-3478","1880-3873"],"issn-type":[{"type":"print","value":"1340-3478"},{"type":"electronic","value":"1880-3873"}],"subject":[],"published":{"date-parts":[[2025,2,1]]},"article-number":"64681"}}