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BMJ, 2011; 342: d636-d636","DOI":"10.1136\/bmj.d636"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Braga PGS, Freitas FR, Bachi ALL, Amirato GR, Baroni R V., Alves MJNN, Vieira RP, Vaisberg MW, Aldin MN, Kalil Filho R, Figueiredo Neto AM, Damasceno NRT, Tavoni TM, Maranh\u00e3o RC. Regular Practice of Physical Activity Improves Cholesterol Transfers to High-Density Lipoprotein (HDL) and Other HDL Metabolic Parameters in Older Adults. Nutrients, 2023; 15: 4871","DOI":"10.3390\/nu15234871"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) R A, G S P, O P. Comparison of body mass index (BMI) with high density lipoprotein (HDL) levels in obese people. Journal of Evidence Based Medicine and Healthcare, 2015; 2: 8412-8416","DOI":"10.18410\/jebmh\/2015\/1147"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Tall AR. Cholesterol efflux pathways and other potential mechanisms involved in the athero\u2010protective effect of high density lipoproteins. J Intern Med, 2008; 263: 256-273","DOI":"10.1111\/j.1365-2796.2007.01898.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Bulpitt CJ, Hodes C, Everitt MG. Intraocular pressure and systemic blood pressure in the elderly. British Journal of Ophthalmology, 1975; 59: 717-720","DOI":"10.1136\/bjo.59.12.717"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Schmidt AM, Hori O, Brett J, Yan SD, Wautier JL, Stern D. Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions. Arterioscler Thromb, 1994; 14: 1521-1528","DOI":"10.1161\/01.ATV.14.10.1521"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Ramasamy R, Vannucci SJ, Yan SS Du, Herold K, Yan SF, Schmidt AM. Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. 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