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Malformation of the erythrocytes in a case of atypical retinitis pigmentosa. Blood, 1950; 5: 381-387","DOI":"10.1182\/blood.V5.4.381.381"},{"key":"2","unstructured":"2) Kane JP, Havel R. Disorders of the biogenesis and secretion of lipoproteins containing the B apolipoproteins., In: Scriver CR, Beaudet AL, Sly WS, Valle D, Vogelstein B, eds. The Metabolic and Molecular Bases of Inherited Disease. 8 ed. Vol 2. New York, NY: McGraw-Hill; 2001: 2717-2752"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Wetterau JR, Aggerbeck LP, Bouma ME, Eisenberg C, Munck A, Hermier M, Schmitz J, Gay G, Rader DJ, Gregg RE. Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science, 1992; 258: 999-1001","DOI":"10.1126\/science.1439810"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Sharp D, Blinderman L, Combs KA, Kienzle B, Ricci B, Wager-Smith K, Gil CM, Turck CW, Bouma ME, Rader DJ, Aggerbeck LP, Gregg RE, Gordon DA, Wetterau JR. 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The role of the microsomal triglygeride transfer protein in abetalipoproteinemia. Annu Rev Nutr, 2000; 20: 663-697","DOI":"10.1146\/annurev.nutr.20.1.663"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Pons V, Rolland C, Nauze M, Danjoux M, Gaibelet G, Durandy A, Sassolas A, Levy E, Terce F, Collet X, Mas E. A severe form of abetalipoproteinemia caused by new splicing mutations of microsomal triglyceride transfer protein (MTTP). Hum Mutat, 2011; 32: 751-759","DOI":"10.1002\/humu.21494"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Di Filippo M, Moulin P, Roy P, Samson-Bouma ME, Collardeau-Frachon S, Chebel-Dumont S, Peretti N, Dumortier J, Zoulim F, Fontanges T, Parini R, Rigoldi M, Furlan F, Mancini G, Bonnefont-Rousselot D, Bruckert E, Schmitz J, Scoazec JY, Charriere S, Villar-Fimbel S, Gottrand F, Dubern B, Doummar D, Joly F, Liard-Meillon ME, Lachaux A, Sassolas A. 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Abetalipoproteinemia: three case reports, a novel microsomal triglyceride transfer protein gene mutation and a literature review. J Clin Case Rep, 2016; 6: 9","DOI":"10.4172\/2165-7920.1000875"},{"key":"33","unstructured":"33) Rafique M, Zia S. Abetalipoproteinemia in a Saudi infant. J Coll Physicians Surg Pak, 2011; 21: 117-118"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Rodr\u00edguez Guti\u00e9rrez PG, Gonz\u00e1lez Garc\u00eda JR, Castillo De Le\u00f3n YA, Z\u00e1rate Guerrero JR, Maga\u00f1a Torres MT. A novel p.Gly417Valfs <sup>\uff0a<\/sup>12 mutation in the MTTP gene causing abetalipoproteinemia: Presentation of the first patient in Mexico and analysis of the previously reported cases. J Clin Lab Anal, 2020; e23672","DOI":"10.1002\/jcla.23672"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Tada H, Usui S, Sakata K, Takamura M, Kawashiri MA. 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Extreme Contrast of Postprandial Remnant-Like Particles Formed in Abetalipoproteinemia and Homozygous Familial Hypobetalipoproteinemia. JIMD Rep, 2015; 22: 85-94","DOI":"10.1007\/8904_2015_415"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Burnett JR, Bell DA, Hooper AJ, Hegele RA. Clinical utility gene card for: Familial hypobetalipoproteinaemia (APOB)--Update 2014. Eur J Hum Genet, 2015; 23: 890","DOI":"10.1038\/ejhg.2014.225"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Peretti N, Sassolas A, Roy CC, Deslandres C, Charcosset M, Castagnetti J, Pugnet-Chardon L, Moulin P, Labarge S, Bouthillier L, Lachaux A, Levy E. Guidelines for the diagnosis and management of chylomicron retention disease based on a review of the literature and the experience of two centers. Orphanet J Rare Dis, 2010; 5: 24","DOI":"10.1186\/1750-1172-5-24"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Kassim SH, Wilson JM, Rader DJ. 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